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31.
Bruna Tadolini Diana Fiorentini Laura Landi Luciana Cabrini 《Free radical research》1989,5(4):245-252
To find experimental conditions to selectively study the propagation phase of lipoperoxidation we studied the lipoperoxidation, catalyzed by FeCl2, of liposomes in a buffering condition where Fe2+ autoxidation and oxygen active species generation does not occur. Liposomes from egg yolk phosphatidylcholine. prepared by vortex mixing, do not oxidize Fe2+: on the contrary they oxidize Fe2+ when prepared by ultrasonic irradiation. Dimyristoyl phosphatidylcholine liposomes prepared by ultrasonic irradiation do not oxidize Fe2+. During sonication polyunsaturated fatty acid residues autoxidize and lipid hydroperoxides (LOOH) are generated. Only when LOOH are present in the liposimes Fe2+ oxidizes and its rate of oxidation depends on the amount of LOOH in the assay. The reaction results in the generation of both LOOH and thiobarbituric acid reactive material (TBAR): it is inhibited by butylated hydroxytoluene and has a acidic pH optimum; it is not inhibited by catalase and OH' scavengers. The reaction studied. thus, appears to be the chain branching and propagation phase of lipoperoxidation. When we studied the dependence of Fe2+ oxidation, LOOH and TBAR generation on FeCl2 concentration, we observed that at high FeCl2 concentrations the termination phase of lipoperoxidation was prevalent. Thus. by selecting the appropriate FeCl2 concentration the proposed experimental system allows study of either the propagation or the termination phase of lipoperoxidation. 相似文献
32.
Tiziana Bellini Diana Degani Maurizio Matteuzzi Franco Dallocchio 《Bioscience reports》1990,10(1):73-78
Pre-treatment of human lymphocytes with 17-estradiol diminishes the increase in concentration of cytosolic free calcium after stimulation with phytohaemagglutinin. The effect is dependent on 17-estradiol concentration and on the preincubation time. The effect is not due to an interaction between 17-estradiol and phytohaemagglutinin, but appears to be a consequence of the binding of the hormone to the cell surface. The effect is specific for 17-estradiol, since the isomer and other steroid hormones (progesterone, testosterone, diethylstilbestrol and 5-androstan), have no effect. Since the effect of the 17-estradiol can be suppressed by treatment of lymphocytes with ouabain, it appears that the effect of estradiol on the rise of cytosolic calcium induced by phytohaemagglutinin is mediated by the (Na, K)-ATPase. 相似文献
33.
34.
Diana Pilson 《Evolution; international journal of organic evolution》1996,50(4):1492-1500
Although most plants experience herbivory by several insect species, there has been little empirical work directed toward understanding plant responses to these simultaneous selection pressures. In an experiment in which herbivory by flea beetles (Phyllotreta cruciferae) and diamondback moths (Plutella xylostella) was manipulated in a factorial design, I found that selection for resistance to these herbivores is not independent in Brassica rapa. Specifically, the effect of flea beetle damage on B. rapa fitness depends on the amount of diamondback moth damage a plant experiences: damage by these herbivores has a nonadditive effect on plant fitness. When diamondbacks are abundant, plants that sustain high levels of damage by flea beetles are favored by natural selection, but when diamondbacks are rare, a low level of damage by flea beetles is favored. However, resistance to the later-feeding diamondback moth is not affected by the presence or absence of damage by early-feeding flea beetles. Thus, there are no plant-mediated ecological interactions between these herbivores that affect the outcome of selection for resistance. Because these herbivores do not independently affect plant fitness, neither is likely to develop a pairwise coevolutionary relationship with its host. Instead, coevolution is diffuse. 相似文献
35.
36.
Chromosomal polymorphism was assessed in the southern short-tailed shrew (Blarina carolinensis) using standard metaphase chromosome and G-banding techniques. Twenty-one animals (11 males, 10 females) from the Meeman Biological Station in Shelby Co., Tennessee, were examined for diploid number. Results showed diploid numbers of 35, 36, 37, 38, 39, 40 and 41 and fundamental numbers of 41, 42, 43, 44 and 45. No diploid numbers or fundamental numbers were unique to a specific collecting locality. The first G-banded karyotypes are reported for the species. These results indicate that Robertsonian polymorphisms, inversions, and possibly other events are responsible for chromosomal variation in B. carolinensis. 相似文献
37.
Jill Lancaster 《Oecologia》1996,107(3):321-331
The effects of hydraulic disturbances on the impact of two predatory benthic invertebrates on their prey were examined in a stream at two distinct spatial scales. At the scale of small habitat patches (0.0625 m2), hydraulic patch type was an important determinant of the microdistribution of prey and predators. Prey abundances were similar across all patch types at baseflow, but local densities were higher in patches identified as low-flow refugia after periods of high and fluctuating flow. The microdistribution pattern of predatory larvae of a caddisfly, Plectrocnemia conspersa, was similar to that of its prey, whereas predatory larvae of an alderfly, Sialis fuliginosa, did not shift their microdistribution significantly with discharge and were always most abundant in lowflow refugia. There was little evidence of an aggregative response of predators with prey, even though both predators and prey are mobile. Both predator species showed similar patch-specific patterns of per capita consumption rates: uniform consumption rates across hydraulic patch types at low and moderate flows, but highest in flow refugia during high flows. Species-specific patterns, however, were apparent in the magnitude and direction of differences between consumption rates during disturbance events, and in comparable patches at base flow: At high flow, consumption rates for P. conspersa were exaggerated (3.9 times higher) in flow refugia but at par in other patches; for S. fuliginosa they were at par in flow refugia but reduced in other patches (up to 3.3. times lower). These differences may be related to species-specific foraging behaviours (search vs ambush predators) and the influence of prey movements on feeding success. Using the patch-scale results only, it is difficult to predict the effects of physical disturbance on predation intensity at the larger scales of whole habitats, populations or communities. At the large scale (>200 m2), net predator impacts were estimated over the stream reach, using a spatially explicit model that accounts, in an additive way, for habitat heterogeneity and patch-specific responses of predators and prey. The relationship between predator impact over the whole reach and hydraulic disturbance differed for the two predators. The predator impact of S. fuliginosa decreased with increasing hydraulic disturbance, as predicted by the harsh-benign hypothesis. There was no directional trend for P. conspersa, however, and maximum predator impact may occur at intermediate disturbance levels. For the prey community in this stream, predation pressure from S. fuliginosa appears to fluctuate directly with the discharge hydrograph, whereas predation from P. conspersa may be more persistent. Flow refugia may play a dual role in the sructure of stream communities by preventing catastrophic mortality of animals (predators and prey) from physical forces during disturbances, and by maintaining (or perhaps increasing) predation pressure. Summing the effects of species interactions in small habitat patches to the larger scale of a whole stream reach indicates that the scale of approach influences the observed patterns and their implied underlying process. 相似文献
38.
Ma Rosario de la Torre Angela Casado Ma Encarnación López-Fernández Diana Carrascosa Ma Concepción Casado Domenico Venarucci Vincenzo Venarucci 《Neurochemical research》1996,21(8):885-888
In order to investigate the role of two free radical detoxificant enzymes in patients with aging brain disorders, superoxide
dismutase (SOD) and catalase (CAT) activities have been measured in blood from male and female human patients of different
ages with several types of aging brain disorders. When compared with activities in the normal population, we have detected:
1) SOD and CAT activities are decreased in patients with Parkinson disease. 2) SOD activity seems to be normal and CAT activity
is decreased in patients with dementia. 3) In the patients with stroke, SOD activity is normal, while CAT activity is decreased.
SOD activity was measured in red blood cells using the Minami and Yoshikawa method. CAT activity was measured in hemolysates
by the method of Aebi. We can conclude that SOD and CAT activities in patients with Parkinson disease are decreased. 相似文献
39.
The behaviour of the endoparasitic tracheal mite, Acarapis woodi (Rennie) on honey bees (Apis mellifera L.) is a challenge to observe because of its small size. Through a microscope, we videotaped this mite's movement on young bees, dead bees and bees exposed to vegetable oil. Previous studies have shown that solid vegetable oil decreases mite infestations in a bee colony. We hypothesized that the oil alters mite behaviour to the detriment of the parasite, thus helping to safeguard the host. Habitat-seeking behaviour, identified as necessary for mites to locate a new host environment, was disrupted on both dead and oil-treated bees. Questing behaviour, which is associated with transfer between hosts, increased significantly on the dead and oily bees. The behaviours of mites were significantly different between all three treatments (x
2=494.96, p<0.001 on dead bees and x
2=851.11, p<0.001 on oily bees). Both questing and seeking behaviours were significantly different on each of the thoracic treatments (F
2,66=7.88, p<0.001 and F
2,66=21.28, p<0.001) and mite questing behaviour was not altered between males and females on live or oily bees (F
1,22=0.25, p<0.62), but habitat seeking was (F
1,22=7.42, p<0.012). The male questing and habitat-seeking behaviours were observed. We conclude that oil-treated bees gained protection from habitat-seeking mites because the normal behaviour of the mites seeking an oviposition site is interrupted. 相似文献
40.
Hillard S. Kaplan Jane B. Lancaster Sara E. Johnson John A. Bock 《Human nature (Hawthorne, N.Y.)》1995,6(4):325-360
Our objective is to test an optimality model of human fertility that specifies the behavioral requirements for fitness maximization
in order (a) to determine whether current behavior does maximize fitness and, if not, (b) to use the specific nature of the behavioral deviations from fitness maximization towards the development of models of evolved
proximate mechanisms that may have maximized fitness in the past but lead to deviations under present conditions. To test
the model we use data from a representative sample of 7,107 men living in Albuquerque, New Mexico, between 1990 and 1993.
The model we test proposes that low fertility in modern settings maximizes number of grandchildren as a result of a trade-off
between parental fertility and next generation fertility. Results do not show the optimization, although the data do reveal
a trade-off between parental fertility and offspring education and income.
We propose that two characteristics of modern economies have led to a period of sustained fertility reduction and to a corresponding
lack of association between income and fertility. The first is the direct link between costs of investment and wage rates
due to the forces of supply and demand for labor in competitive economies. The second is the increasing emphasis on cumulative
knowledge, skills, and technologies in the production of resources. Together they produce historically novel conditions. These
two features of modern economies may interact with evolved psychological and physiological mechanisms governing fertility
and parental investment to produce behavior that maximizes the economic productivity of lineages at the expense of fitness.
If cognitive processes evolved to track diminishing returns to parental investment and if physiological processes evolved
to regulate fertility in response to nutritional state and patterns of breast feeding, we might expect non-adaptive responses
when returns from parental investment do not diminish until extremely high levels are reached. With high economic payoffs
from parental investment, people have begun to exercise cognitive regulation of fertility through contraception and family
planning practices. Those cognitive processes maynot have evolved to handle fitness trade-offs between fertility and parental investment.
A preliminary presentation of this data was published in R. I. M. Dunbar, ed.,Human Reproduction Decisions: Biological and Social Perspectives. New York: St. Martin’s Press, 1995. Support for the research project, “Male Fertility and Parenting in New Mexico,” began
with two seed grants from the University of New Mexico’s Biomedical Research Grants Program, 1988 and 1989, and one from the
University of New Mexico Research Allocations Committee, 1988. Further seed money as well as interim funding came from the
William T. Grant Foundation (#89130589 and #91130501). The major support for the project came from the National Science Foundation
from 1990 to 1993 (#BNS-9011723 and #DBS-911552). Both National Science Foundation grants included Research Experience for
Undergraduates supplements.
Hillard S. Kaplan is an Associate Professor of Anthropology at the University of New Mexico. His earlier research and publications
focused on food sharing, time allocation, parental investment, and reproductive strategies among Ache hunter-gatherers in
Paraguay, Machiguenga and Piro forager-horticulturalists in Peru, and villagers of several ethnicities in Botswana. New research
and theory concern fertility, parental investment, and mating strategies in developed and developing nations. This research
formulates a new theory of reproductive decision-making and the demographic transition, integrating human capital and parental
investment theory in a synthesis of economic and evolutionary approaches.
Jane B. Lancaster is a Professor of Anthropology at the University of New Mexico. Her research and publications are on human
reproductive biology and behavior, especially human parental investment; women’s reproductive biology of pregnancy, lactation,
and child-spacing; and male fertility and investment in children. Current research with Hillard S. Kaplan is on male life
history strategies among a large sample of men in New Mexico. She has coedited three books on human parental investment:School-Age Pregnancy and Parenthood (with B. Hamburg),Parenting across the Life Span (with J. Altmann, A. Rossi, and L. Sherrod), andOffspring Abuse and Neglect (with R. Gelles). She is scientific editor of a quarterly journal,Human Nature: An Interdisciplinary, Biosocial Perspective published by Aldine de Gruyter. She is also a council member of the newly formed Human Behavior and Evolution Society.
John A. Bock is Andrew W. Mellon Post-Doctoral Fellow in Epidemiology and Population Health at the National Centre for Epidemiology
and Population Health, The Australian National University. His research focuses on the allocation of parental investment and
the determinants of children’s activities, integrating aspects of economic and evolutionary theory. He has ongoing field research
with Bantu and Bushmen agro-pastoralists and forager-horticulturalists in the Okavango Delta, Botswana. He is also collaborating
with Lancaster and Kaplan on the determinants of progeny distribution and homosexuality among New Mexican men.
Sara E. Johnson is a Ph.D. candidate at the University of New Mexico. Her major research trajectory focuses on trade-offs
in life history characters. Her research experience includes participation in a study of variation in growth and development
among children in a multi-ethnic community in the Okavango Delta, Botswana, in addition to her dissertation work on individual
variation in growth and mortality among juvenile baboons. She is collaborating with Lancaster and Kaplan on the association
between survival and fertility among Albuquerque men. 相似文献