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141.
Abishek Suresh Velmurugan Karthikraja Sajitha Lulu Uma Kangueane Pandjassarame Kangueane 《Bioinformation》2009,4(5):197-205
The formation of protein homodimer complexes for molecular catalysis and regulation is fascinating. The homodimer formation through 2S
(2 state), 3SMI (3 state with monomer intermediate) and 3SDI (3 state with dimer intermediate) folding mechanism is known for 47
homodimer structures. Our dataset of forty-seven homodimers consists of twenty-eight 2S, twelve 3SMI and seven 3SDI. The dataset is
characterized using monomer length, interface area and interface/total (I/T) residue ratio. It is found that 2S are often small in size with large
I/T ratio and 3SDI are frequently large in size with small I/T ratio. Nonetheless, 3SMI have a mixture of these features. Hence, we used
these parameters to develop a decision tree model. The decision tree model produced positive predictive values (PPV) of 72% for 2S, 58%
for 3SMI and 57% for 3SDI in cross validation. Thus, the method finds application in assigning homodimers with folding mechanism. 相似文献
142.
Cognitive Neurodynamics - In this paper, the problem of the existence, uniqueness and uniform stability of memristor-based fractional-order neural networks (MFNNs) with two different types of... 相似文献