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961.
Matheus D. Baldissera Carine F. Souza Thirssa H. Grando Michele R. Sagrillo Aleksandro S. da Silva Lenita M. Stefani Silvia G. Monteiro 《Molecular and cellular biochemistry》2017,432(1-2):159-167
Diabetes increases the risk of vascular events and mortality. While earlier type 2 diabetes trials demonstrated that intensive glucose lowering reduces microvascular complications, it is only recently that treatment with some of the newer antihyperglycemic agents has been associated with macrovascular benefits. We report herein that db/db mice concomitantly fed the Western diet and treated with the anti-inflammatory agent methotrexate display a less aggressive inflammatory (lower serum IL-1β, IL-6, SDF-1, and TNFα levels; higher circulating adiponectin, IL-12p70 and IL-10 concentrations; lower aortic VCAM-1 levels) profile than their saline-treated counterpart. Furthermore, acetylcholine-elicited endothelium-dependent vasodilatation was significantly greater in thoracic aortic segments from the former group. Collectively, the data lend support to the notion that alterations in the inflammatory system may be involved in the macrovascular benefits observed in type 2 diabetes trials and provide credence for the development of anti-inflammatory tools to lower CV risk and CV events in diabetes. 相似文献
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Carine Strübin Marc Steinegger Redouan Bshary 《Ethology : formerly Zeitschrift fur Tierpsychologie》2011,117(11):961-969
Intraspecific group hunting has received considerable attention by researchers interested in cooperative behaviour and animal cognition. Differences between species in the complexity of the hunting with respect to communication, coordination and food sharing have typically been interpreted as a reflection of differences in cognitive abilities. Here we describe for the first time collaborative hunting where individuals play different roles in a fish species, the yellow saddle goatfish Parupeneus cyclostomus. Adults in our study area may live either solitarily or in relatively stable groups formed of similar sized and most likely unrelated individuals. The solitary life style was associated with searching for hidden immobile prey on sandy areas while group living was associated with collaborative hunting of mobile prey in corals. Any member of a group could initiate a hunt by rapid acceleration. Partners did not simply follow the attacker but deviated around coral formation to block the prey’s escape routes. Prey that escaped into a coral crevice was typically encircled with maximal inter‐individual distance and pried on by insertion of the barbels into the crevices. As home ranges largely overlapped and no between‐group aggression existed, we propose that it is the hunting of mobile prey in a complexly structured habitat that selects for collaborative hunting and hence for the evolution of group living in yellow saddle goatfish. 相似文献
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