全文获取类型
收费全文 | 363篇 |
免费 | 15篇 |
出版年
2023年 | 1篇 |
2022年 | 7篇 |
2021年 | 5篇 |
2020年 | 8篇 |
2019年 | 5篇 |
2018年 | 10篇 |
2017年 | 13篇 |
2016年 | 17篇 |
2015年 | 7篇 |
2014年 | 14篇 |
2013年 | 14篇 |
2012年 | 20篇 |
2011年 | 19篇 |
2010年 | 19篇 |
2009年 | 14篇 |
2008年 | 24篇 |
2007年 | 30篇 |
2006年 | 12篇 |
2005年 | 18篇 |
2004年 | 10篇 |
2003年 | 12篇 |
2002年 | 11篇 |
2001年 | 12篇 |
2000年 | 17篇 |
1999年 | 7篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 7篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1968年 | 2篇 |
1967年 | 3篇 |
1966年 | 2篇 |
1963年 | 2篇 |
排序方式: 共有378条查询结果,搜索用时 15 毫秒
371.
Stefani Vircheva Galina Nenkova Almira Georgieva Albena Alexandrova Elina Tzvetanova Polina Mateeva Rositsa Zamfirova Margarita Kirkova 《Cell biochemistry and function》2012,30(1):18-23
The pathogenesis of many diseases and different pathological conditions, including inflammation, is associated with excess production of reactive oxygen species (ROS). The present study aimed to investigate the effects of the antidepressant desipramine (DES) on carrageenan (CG)‐induced inflammation, as well as on the endogenous levels of cell enzyme and non‐enzyme antioxidants in rat liver and spleen, 4 and 24 h after CG injection. The intra‐plantar CG injection into the right hind paw resulted in a time‐dependent increase in the paw volume; the maximum of CG‐induced edema peak was in 2–4 h. A single DES dose of 20 mg·kg?1, administered 30 min before CG, had no effect on paw edema, whereas the higher drug dose used (50 mg·kg?1) suppressed the edematous response to CG. The latter drug dose protected CG‐induced decrease of glutathione (non‐enzyme antioxidant) in the liver; it did not affect CG‐unchanged activities of superoxide dismutase, glutathione peroxidase (enzyme antioxidants) and glucose‐6‐phosphate dehydrogenase (enzyme, important for the activity of glutathione‐conjugated antioxidant enzymes) in both liver and spleen. The drug showed an efficient antioxidant capacity in ROS‐generating chemical systems; it was higher than that of fluoxetine (another type of antidepressant). The present results suggest that the good antioxidant activity of DES might contribute to its beneficial effects in liver injuries. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
372.
373.
Two new homologs of human (h) TAFII30, dTAFII16 and dTAFII24 were revealed inDrosophila melanogaster. The proteins are encoded by neighboring genes and bind with the TATA-binding protein and other dTAFII proteins involved in TFIID. Only dTAFII24 interacts with GCN5 histone acetyltransferase (HAT), which is the first demonstration of the TAFII-GCN5-HAT complex inD. melanogaster. The two proteins have both common and individual location sites on polytene chromosomes. Possibly, the functions of dTAFII16 and dTAFII24 are similar but not identical. 相似文献
374.
375.
α-Amino acids (glycine, serine, histidine, aspartic acid and cysteine) and dithiothreitol (DTT) have been shown to activate both activities of the NAD(NADP)-dependent glyceraldehyde-3-phosphate dehydrogenase from Chlorella. The activation is allosteric and reaches 200–700%. The Hill coefficient values are close to 2 with all activators. ATP activates NADP-dependent but inhibits NAD-dependent activity, napp and K values being the same for both enzyme activities. In this case positive cooperativity is also observed (napp = 2.2). The present findings reveal the possible regulation of GAPD function in Chlorella with each of the coenzymes. 相似文献
376.
377.
378.
Yeast microorganisms from Candida genus are investigated for their superoxide dismutase (SOD) and catalase activity during cultivation on N-alkanes. The later caused a considerable increase of Cu/Zn SOD activity of yeast cells in comparison with glucose. A correlation between SOD and catalase activity existed. It is further observed that cells of Candida lipolytica 68-72 which contain a high level of Cu/Zn SOD were more resistant to lethality of exogenous O2-. An over-production of Cu/Zn SOD during the assimilation of N-alkanes by yeasts is also connected to their considerable resistance to increased concentrations of Cu2+ and Zn2+ ions in the nutrient medium. The results are consistent with the assumption that the enhanced resistance of yeast cells to O2- and high concentrations of Cu2+ and Zn(2+)-ions are due to the increased activity of Cu/Zn SOD and that SOD is involved in the protection of some cellular components. Polyacrylamide gel electrophoresis of Candida lipolytica cell-free extracts revealed the same chromatic bands of SOD activity under growth on glucose and N-alkanes. The type of the carbon source used from yeast cells as a single source of carbon and energy had no influence on the SOD profile of the cell. 相似文献