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101.
102.
Han Xu Xubin Pan Yun Song Ying Huang Minmin Sun Shuifang Zhu 《Biodiversity and Conservation》2014,23(10):2637-2643
Alien species are brought into countries world wide on a massive scale for agricultural production, ex situ conservation, landscape aesthetics, gardens, and ecosystem restoration. Unfortunately, some of these species have escaped and adversely impacted on regional as well as global biodiversity conservation and agricultural production. To reduce such risks, it is necessary to implement specific and effective measures. Since various government departments and institutions are involved in the management of alien species, it is difficult to prevent native and agroecosystems from being invaded by invited species. We propose the establishment of a supervision and inspection continuum over intentional species introduction, similar to that which exists in some countries over unintentional species introductions. Namely, a justification of the necessity to import, a risk assessment, assurances as to provision of an adequate containment facility assessment, and a damage-limitation protocol should that need to be invoked. These requirements should be satisfied before an alien species is knowingly imported, and the necessary follow-up supervision is important post- importation. 相似文献
103.
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105.
Han Wang Qian Zhang BinBin Wang WangJun Wu Julong Wei Pinghua Li Ruihua Huang 《European journal of cell biology》2018,97(4):257-268
Recently, miR-22 was found to be differentially expressed in different skeletal muscle growth period, indicated that it might have function in skeletal muscle myogenesis. In this study, we found that the expression of miR-22 was the most in skeletal muscle and was gradually up-regulated during mouse myoblast cell (C2C12 myoblast cell line) differentiation. Overexpression of miR-22 repressed C2C12 myoblast proliferation and promoted myoblast differentiation into myotubes, whereas inhibition of miR-22 showed the opposite results. During myogenesis, we predicted and verified transforming growth factor beta receptor 1 (TGFBR1), a key receptor of the TGF-β/Smad signaling pathway, was a target gene of miR-22. Then, we found miR-22 could regulate the expression of TGFBR1 and down-regulate the Smad3 signaling pathway. Knockdown of TGFBR1 by siRNA suppressed the proliferation of C2C12 cells but induced its differentiation. Conversely, overexpression of TGFBR1 significantly promoted proliferation but inhibited differentiation of the myoblast. Additionally, when C2C12 cells were treated with different concentrations of transforming growth factor beta 1 (TGF-β1), the level of miR-22 in C2C12 cells was reduced. The TGFBR1 protein level was significantly elevated in C2C12 cells treated with TGF-β1. Moreover, miR-22 was able to inhibit TGF-β1-induced TGFBR1 expression in C2C12 cells. Altogether, we demonstrated that TGF-β1 inhibited miR-22 expression in C2C12 cells and miR-22 regulated C2C12 cell myogenesis by targeting TGFBR1. 相似文献
106.
Kim CH Pennisi P Zhao H Yakar S Kaufman JB Iganaki K Shiloach J Scherer PE Quon MJ LeRoith D 《American journal of physiology. Endocrinology and metabolism》2006,291(2):E298-E305
Most rodent models of insulin resistance are accompanied by decreased circulating adiponectin levels. Adiponectin treatment improves the metabolic phenotype by increasing fatty acid oxidation in skeletal muscle and suppressing hepatic glucose production. Muscle IGF-I receptor (IGF-IR)-lysine-arginine (MKR) mice expressing dominant-negative mutant IGF-IRs in skeletal muscle are diabetic with insulin resistance in muscle, liver, and adipose tissue. Adiponectin levels are elevated in MKR mice, suggesting an unusual discordance between insulin resistance and adiponectin responsiveness. Therefore, we investigated the metabolic actions of adiponectin in MKR mice. MKR and ob/ob mice were treated both acutely (28 microg/g) and chronically (for 2 wk) with full-length adiponectin. Acute hypoglycemic effects of adiponectin were evident only in ob/ob mice but not in MKR mice. Chronic adiponectin treatment significantly improved both insulin sensitivity and glucose tolerance in ob/ob but not in MKR mice. Adiponectin receptor mRNA levels and adiponectin-stimulated phosphorylation of AMPK in skeletal muscle and liver were similar among MKR, wild-type, and ob/ob mice. Thus MKR mice are adiponectin resistant despite normal expression of adiponectin receptors and normal AMPK phosphorylation in muscle and liver. MKR mice may be a useful model for dissecting relationships between insulin resistance and adiponectin action in regulation of glucose homeostasis. 相似文献
107.
To obtain an overall view on gene expression during the early stage (24 h) of tomato fruit in response to postharvest UV-C irradiation (4 kJ/m(2)), we performed a microarray analysis by using Affymetrix Tomato Genechip. The results showed that 274 and 403 genes were up- or down-regulated, respectively, more than two folds in postharvest tomato fruit irradiated with UV-C as compared with that in control fruit. The up-regulated genes mainly involve in signal transduction, defense response and metabolism. Conversely, genes related to cell wall disassembly, photosynthesis and lipid metabolism were generally down-regulated. These results opened ways to probe into the molecular mechanisms of the effects of postharvest UV-C irradiation on increased disease resistance, delayed softening, better quality maintenance and prolonged postharvest life in tomato fruit. 相似文献
108.
The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription 总被引:13,自引:0,他引:13
Zhao L Guo M Matsuoka TA Hagman DK Parazzoli SD Poitout V Stein R 《The Journal of biological chemistry》2005,280(12):11887-11894
109.
不同预处理对大麦花药3种内源激素含量和过氧化物酶活性的影响 总被引:5,自引:0,他引:5
研究了大麦(Hordeum vulgare L.)花药-花粉培养中不同预处理对花药内源激素(ABA,IAA,IPA)含量和过氧化物酶活性的影响。结果表明:1. 经甘露醇预处理不同天数,同一种基因型的3种内源激素的变化和不同基因型的同一种内源激素的变化规律十分相似,均是在预处理初期含量急剧增加,最高值在0.5或1 d 处。以后开始逐渐下降;最后,保持在一定的水平上。2. 在甘露醇预处理过程中,两种基因型花药过氧化物酶活性的变化规律也十分相似。在预处理前期(从开始到第3天)活性呈直线上升,第3天达到最大值。从第3天到第5天活性减弱。最后,活性又开始增强。3. 在低温预处理过程的初期(2~5 d) 两种基因型花药过氧化物酶活性都出现第一个小峰。在第14天(“Harrington”)或第21天(“Igri”)又出现第二个峰值,但后者较高。在预处理的后期(从第28天到第35天)两种基因型花药过氧化物酶的活性又呈现上升的趋势。同甘露醇预处理后期变化一致 相似文献
110.