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61.
Diane Moujalled Pradnya Gangatirkar Maria Kauppi Jason Corbin Marion Lebois James M. Murphy Najoua Lalaoui Joanne M. Hildebrand John Silke Warren S. Alexander Emma C. Josefsson 《Cell death & disease》2021,12(1)
Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). Previous studies suggested a role for the necroptotic machinery in platelets, where loss of MLKL or its upstream regulator, RIPK3 kinase, impacted thrombosis and haemostasis. However, it remains unknown whether necroptosis operates within megakaryocytes, the progenitors of platelets, and whether necroptotic cell death might contribute to or diminish platelet production. Here, we demonstrate that megakaryocytes possess a functional necroptosis signalling cascade. Necroptosis activation leads to phosphorylation of MLKL, loss of viability and cell swelling. Analyses at steady state and post antibody-mediated thrombocytopenia revealed that platelet production was normal in the absence of MLKL, however, platelet activation and haemostasis were impaired with prolonged tail re-bleeding times. We conclude that MLKL plays a role in regulating platelet function and haemostasis and that necroptosis signalling in megakaryocytes is dispensable for platelet production.Subject terms: Necroptosis, Experimental models of disease 相似文献
62.
Najoua Karray-Bouraoui Faten Harbaoui Mokded Rabhi Inès Jallali Riadh Ksouri Houneida Attia Najoua Msilini Mokhtar Lachaâl 《Acta Physiologiae Plantarum》2011,33(4):1435-1444
Seedlings of two Tunisian Carthamus tinctorius L. provenances (Kairouan and Tazarka) differing in salt sensitivity were hydroponically grown at 0 and 50 mM NaCl over 21 days.
Leaves of Kairouan (salt-sensitive) showed a 48% restriction in their growth at 50 mM NaCl although they accumulated less
sodium than those of Tazarka (less salt-sensitive) that maintained an unchanged growth. Salt treatment induced oxidative stress
in C. tinctorius and the effect was more pronounced in the leaves of the more salt sensitive provenance, Kairouan. Both provenances exhibited
a stimulation of antioxidant enzyme activities with higher catalase (CAT) and superoxide dismutase (SOD) activities in Tazarka
and higher peroxidase (POD) activity in Kairouan. But, it seems that antioxidant activities were more correlated with polyphenol
content. Actually, leaves of Tazarka experienced higher polyphenol and antioxidant activity than Kairouan at 50 mM NaCl. Hence,
moderate salinity (3 g NaCl L−1) enhanced bioactive molecule yield in the less salt sensitive provenance, Tazarka. In addition, C. tinctorius was found rich in ascorbic acid, but the moderate salt stress enhanced its production only in the sensitive provenance. 相似文献
63.
A study on the relative growth and reproductive cycle of the purple dye murex (Bolinus brandaris) was performed from March 2007 to February 2008 in two populations with contrasting imposex levels (Carthage Byrsa — CB in
the small Gulf of Tunis and Menzel Abderrahmane — MA in the Bizerta Lagoon). Both populations presented balanced sex ratios.
Comparison of allometric relationships established between linear and ponderal variables (sexes confounded) revealed higher
growth in CB than in MA. Mature individuals were found throughout the year, except for September in MA. Spawning periods occurred
from March–April to May and from June to August in both sites. Spawning was associated to an increase in seawater temperature.
Besides increasing the current knowledge on the biology of B. brandaris from the southern Mediterranean, the information gathered in the present study constitutes a useful baseline for the sustainable
management of local wild stocks, namely by prohibiting collection of snails during the spawning season. 相似文献
64.
Najla Chargui Najoua Haouas Darine Slama Mohamed Gorcii Kaouther Jaouadi Nawel Essabbah‐Aguir Habib Mezhoud Hamouda Babba 《Journal of vector ecology》2013,38(1):1-5
Visceral leishmaniasis (VL) has been endemic in northern Tunisia and has occurred sporadically in the center of Tunisia. Recently, there have been several cases from areas known to be free of VL. We report in this work all human and canine cases of VL recorded between 2003 and 2011 and an entomological study of phlebotomine fauna in a previously non‐endemic region. Sixty‐three cases of VL were diagnosed and identified as L. infantum using several different methods. Eight species of 179 sand flies were caught and identified by both morphological and molecular methods. Two genera were present, Phlebotomus and Sergentomya, with an abundance of the subgenus Phlebotomus (Larrousius) spp., a classic vector of VL in Tunisia. Moreover, Leishmania DNA was detected in seven unfed Phlebotomus pernicousus and L. infantum was identified in three of them. This result confirms the establishment of a transmission cycle of VL in the studied region by the coexistence of infected vectors with infected hosts. 相似文献