Possibilities of using the protective activity of MIGI-K under conditions of radionuclide contamination

Experimental studies of mussel hydrolyzate MIGI-K show that this drug has the ability to increase the general and radiation resistance of the human body. Moreover, MIGI-K facilitates elimination of incorporated radionuclides from the body. A series of properties of this drug, in particular, the absence of toxicity or harmful side effects, makes it possible to apply MIGI-K as an adaptogen (a food supplement exhibiting therapeutic and preventive action and used to increase excretion of radionuclides from people who took part in the liquidation of the accident at the Chernobyl Nuclear Plant).     

The effect of x-ray irradiation on the cytochrome P-450-dependent mono-oxygenase system of the liver in different animal species

The whole X-irradiation (7 Gy) of male rat, mouse and guinea-pig caused in general similar alterations in the content of cytochrome P-450 and aminopyrine-N-demethylase activity in liver microsomes. On the 5-7th day after irradiation the parameters were 39-79% of the normal level. The same postradiation changes were observed in females of these animal species but in females of rats and guinea-pigs the effect was less expressed. The depression of activity in liver microsomal cytochrome P-450-dependent monooxygenase system has been concluded to be one of the characteristic features of acute form in radiation damage.