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31.
Ibuprofen, a unique anti-inflammatory compound with antifungal activity against dermatophytes 总被引:2,自引:2,他引:0
Ibuprofen showed significant antifungal activity in vitro against dermatophytes at pH 5 (MIC: 5–40 μg ml-1 ). In this respect it is comparatively more efficient than two well known and medically used antifungal compounds, benzoic and salicylic acids. This compound with anti-inflammatory activity which is not found in any other conventional antifungal organic acids, may have clinical prospects. 相似文献
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The optical density (450 nm) of samples of homogenized fungal biomass correlated linearly with the dry weight of the biomass in the samples. As shown for broths of the filamentous microfungus Neurospora sitophila, the sensitivity of the technique depended on the extent of fragmentation of fungal hyphae during homogenization: increased fragmentation increased sensitivity. The method applied during all phases of growth, was as accurate as the conventional dry weight technique and permitted rapid and simple measurement of biomass concentration. 相似文献
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Richard H. Sugatt Dean P. O'Grady Sujit Banerjee Philip H. Howard W. E. Gledhill 《Applied microbiology》1984,47(4):601-606
An acclimated shake flask CO2 evolution test was used to study the biodegradability of 14 commercial phthalate esters that are commonly used as plasticizers. Both CO2 evolution (ultimate biodegradation) and loss of parent phthalate esters (primary biodegradation) were measured. With only a few exceptions, primary biodegradation was 90% or higher, and ultimate biodegradation was in excess of 55% of theoretical results in 28 days. The results showed that all of the commercial phthalate esters were susceptible to biodegradation by mixed populations of microorganisms from natural sources. The results also provide considerable insight into the utility and reproducibility of a standard biodegradation test that is being recommended for widespread screening of chemicals. 相似文献
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A.K. Banerjee B.J. Broughton T.S. Burton M.P.L. Caton A.J. Christmas E.C.J. Coffee K. Crowshaw M.A. Heazell K.A.J. Stuttle G.L. Watkins 《Prostaglandins & other lipid mediators》1978,16(4):541-554
The synthesis and gastrointestinal pharmacology of some 11-deoxyprostaglandin E1 analogues are described with results analysed for selectivity from side effects. 11-Deoxygenation reduced potency relative to PGE2 but, as has been reported for natural PGs, 15- or 16-methyl analogues were more potent than the unsubstituted parent compound in the order 16-methyl > 15-methyl > 16, 16-dimethyl. The results suggest that a complex interaction between C-15 and C-16 in methyl analogues affects their profile of activity, but that none of the modifications studied conferred a substantial potency or selectivity advantage over PGE2. 相似文献
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A K Banerjee 《Microbiological reviews》1980,44(2):175-205
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