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I. M. Yermak V. N. Davydova 《Biochemistry (Moscow) Supplemental Series A: Membrane and Cell Biology》2008,2(4):279-295
Lipopolysaccharides (LPS) are unique cell wall components of gram-negative bacteria. They represent amphiphilic biopolymeric compounds combining in a single molecule hydrophilic (O-specific chains, core oligosaccharide, etc.) and hydrophobic (lipid A) entities. LPS play a crucial role in various interactions between micro- and macroorganisms and display a broad range of biological activities including toxic activity and ability to activate immune cells. Biological activities of LPS are based on their ability to bind with high affinity to mammalian proteins, e.g., lipoproteins, bactericidal permeability-increasing proteins, lysozyme, etc., and thus to neutralize toxic effects of endotoxins. LPS are specific targets for antimicrobial polycationic compounds used in the therapy of bacterial infections. Studies of mechanisms of toxic effects of LPS culminated in the development of novel approaches to LPS neutralization. One of them is based on the use of compounds able to neutralize LPS toxicity at the expense of formation of macromolecular complexes with them. This approach is highly specific and has no effect on functional activity of antipathogenic defense mechanisms of the host. Interaction of LPS with various classes of cationic amphiphilic molecules including proteins, peptides, and polyamines was the subject of intensive studies in the past decade. Binding of cationic polymers is provided by electrostatic interactions between LPS and negatively charged phosphate and carboxylic groups of LPS localized in lipid A core. The present study is an overview of recently published data on different mechanisms of interactions of LPS with soluble proteins and polycations and modification of physiological activity of LPS. 相似文献
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Davydova VN Bratskaya SY Gorbach VI Solov'eva TF Kaca W Yermak IM 《Biophysical chemistry》2008,136(1):1-6
Electrokinetic properties of complexes of chitosan (Ch) with lipopolysaccharides (LPSs) from Escherichia coli O55:B5, Yersinia pseudotuberculosis 1B 598, and Proteus vulgaris O25 (48/57) and their size distribution were investigated using zeta-potential distribution assay and quasi-elastic light scattering. The interaction of LPS from different microorganisms with chitosan at the same w/w ratio of components (1:1) resulted in the formation of complexes in which the negative charge of LPS was neutralized (LPS from E. coli) or overcompensated (Y. pseudotuberculosis and P. vulgaris). The changing in size of the endotoxin aggregates during binding with chitosan was observed. The binding constants of chitosan with LPSs were determined by a method with using the anionic dye Orange II. The LPS from E. coli possess higher affinity to chitosan in comparison with the two others samples of endotoxin. 相似文献
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Cicada acoustic communication: potential sound partitioning in a multispecies community from Mexico (Hemiptera: Cicadomorpha: Cicadidae) 总被引:1,自引:0,他引:1
JÉRÔME SUEUR 《Biological journal of the Linnean Society. Linnean Society of London》2002,75(3):379-394
Multispecies cicada communities in neotropical rainforests produce a complex and intense acoustic environment. In a fragment of a Mexican rainforest (Veracruz, Mexico), a cicada community at the end of the dry season consisted of nine species ( Daza montezuma; Pacarina schumanni; Miranha imbellis; Dorisiana sutori; Fidicinoides picea; Fidicinoides pronoe; Quesada gigas; one species of the genus Neocicada and one uncaught canopy species). Seven of the nine species formed dense choruses at dawn and at dusk. Each species showed preferences in the height of calling sites. Males of the species were solitary or gregarious, and followed a 'call-fly' or a 'call-stay' calling strategy. Acoustic signals of each species had particular time and frequency patterns. All these specific features appear to separate the nine species acoustically and lead to a partitioning of the acoustic environment. The acoustic partitioning might decrease the risk of heterospecific courting and mating.© 2002 The Linnean Society of London, Biological Journal of the Linnean Society , 2002, 75 , 379–394. 相似文献
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The optic nerve of the tortoise Agrionemys horsfieldi contains about 400,000 fibers (90% unmyelinated and 10% myelinated ones). the diameter of unmyelinated fibers varies from 0.3 to 1.1 mu, mean value being equal to 0.5 mu; fibers with a diameter 0.4-0.7 comprise 77%. The diameter of myelinated fibers varies within 0.3-3.0 mu, average value being 0.5-0.8 nu; fibers with a diameter 0.5-0.9 mu amount to 62%. Electrogram of the optic nerve consists of two components which are equal in their amplitudes. These components presumably reflect summary firings of modal groups of unmyelinated and myelinated fibers. The velocity of propagation of excitation along the fibers producing the first component is equal to 1.3 m/sec, wheras that in fibers producing the second component - to 0.5 m/sec. The data obtained are compared with those related for the other tortoise - Emys orbicularis. 相似文献
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O. B. Flekhter L. T. Karachurina V. V. Poroikov L. P. Nigmatullina L. A. Baltina F. S. Zarudii V. A. Davydova L. V. Spirikhin I. P. Baikova F. Z. Galin G. A. Tolstikov 《Russian Journal of Bioorganic Chemistry》2000,26(3):192-200
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, andp-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin
esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor.
These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bishemiphthalate
was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol. 相似文献