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101.
Allan H. Rappaport Paul B. Hoffer Harry K. Genant 《The Western journal of medicine》1978,129(3):188-192
Preliminary findings suggest that in patients with known primary cancer, a large percentage of unifocal lesions seen on radionuclide bone scans are not metastatic. In a survey of radionuclide bone studies done on 861 consecutive patients, 30 patients with known primary cancer had solitary lesions. Adequate follow-up information was available on 21 of these 30 patients. In only four did the lesions prove to be caused by metastatic malignancy. 相似文献
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Djuro Josi
Petra Schulz Lothar Biesert Lutz Hoffer Horst Schwinn Mira Kordis-Krapez Ales Strancar 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1997,694(2)
Product development and process validation are shown in the case of several products obtained from human plasma. These are virus-inactivated plasma, intravenous immunoglobulins and the clotting factors VIII and IX. Different analytical methods are presented, which are used for product control and in-process control. For the production of virus-inactivated human plasma a down-scale protocol is presented, allowing a simulation of the production on a laboratory scale. Virus validation has shown that the reduction of transfusion-relevant viruses in the process was higher than six log steps. Determination of leachables from the RP-column, which was used in this production, proved that they appear in the final product in quantities below the detection limits only. It was also shown that the chemicals used for virus inactivation could be quantitatively removed from the product. For the isolation of other products, here intravenous gamma globulins and the clotting factors VIII and IX, similar validation steps had to be taken. In the case of clotting factor VIII the following data were determined, the reduction of viruses, the amount of leachables from the column, the residues of chemicals from the solvent/detergent treatment for virus inactivation. Virus reduction was successfully performed as well as the removal of chemicals used for virus inactivation. The amount of leachables from the columns used for chromatographic purification was found to be far below the permissible levels. 相似文献
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. Erküner M. van Eck O. Xhaet H. Verheij J. Neefs A. Duygun R. Nijmeijer S. A. M. Saïd H. Uiterwaal V. Hagens R. Bhagwandien T. Szili-Torok N. Bijsterveld G. Tjeerdsma J. Vijgen A. Friart E. Hoffer P. Evrard M. Srynger J. Meeder J. R. de Groot J. van Opstal R. Gevers G. Y. H. Lip G. Boriani H. J. G. M. Crijns J. G. L. M. Luermans G. H. Mairesse 《Netherlands heart journal》2021,29(11):584
BackgroundContemporary data regarding the characteristics, treatment and outcomes of patients with atrial fibrillation (AF) are needed. We aimed to assess these data and guideline adherence in the EURObservational Research Programme on Atrial Fibrillation (EORP-AF) long-term general registry.MethodsWe analysed 967 patients from the EORP-AF long-term general registry included in the Netherlands and Belgium from 2013 to 2016. Baseline and 1‑year follow-up data were gathered.ResultsAt baseline, 887 patients (92%) received anticoagulant treatment. In 88 (10%) of these patients, no indication for chronic anticoagulant treatment was present. A rhythm intervention was performed or planned in 52 of these patients, meaning that the remaining 36 (41%) were anticoagulated without indication. Forty patients were not anticoagulated, even though they had an indication for chronic anticoagulation. Additionally, 63 of the 371 patients (17%) treated with a non-vitamin K antagonist oral anticoagulant (NOAC) were incorrectly dosed. In total, 50 patients (5%) were overtreated and 89 patients (9%) were undertreated. However, the occurrence of major adverse cardiac and cerebrovascular events (MACCE) was still low with 4.2% (37 patients).ConclusionsOvertreatment and undertreatment with anticoagulants are still observable in 14% of this contemporary, West-European AF population. Still, MACCE occurred in only 4% of the patients after 1 year of follow-up.Supplementary InformationThe online version of this article (10.1007/s12471-021-01634-y) contains supplementary material, which is available to authorized users. 相似文献
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Activation by Gene Amplification of pitB, Encoding a Third Phosphate Transporter of Escherichia coli K-12 总被引:1,自引:0,他引:1
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Sally M. Hoffer Paul Schoondermark Hendrik W. van Veen Jan Tommassen 《Journal of bacteriology》2001,183(15):4659-4663
Two systems for the uptake of inorganic phosphate (P(i)) in Escherichia coli, PitA and Pst, have been described. A revertant of a pitA pstS double mutant that could grow on P(i) was isolated. We demonstrate that the expression of a new P(i) transporter, PitB, is activated in this strain by a gene amplification event. 相似文献