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91.
Piccinini Alexandre Oliveira Mariana Pacheco Silva Mariella Reinol Bett Gabriela Souza Becker Isabel Borges Mendes Talita Farias Salla Daniéle Hendler Silva Larissa Espindola Vilela Thais Ceresér Moraes Fernanda Mendes Moterle Diego Damiani Adriani Paganini Dagostin Lígia Salvan Tietbohl Lariani Tamires Bittencourt João Vitor Silvano Biehl Erica Denicol Tais Luise Bonfante Sandra Regina Andrade Vanessa Moraes Silveira Paulo Cesar Lock Prophiro Josiane Somariva Ferreira Gabriela Kozuchovski Petronilho Fabricia Kanis Luiz Alberto Rezin Gislaine Tezza 《Neurochemical research》2022,47(7):1888-1903
Neurochemical Research - This study aimed to evaluate the effect of Cynara cardunculus leaf ethanol extract on inflammatory and oxidative stress parameters in the hypothalamus, prefrontal cortex,... 相似文献
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Abarca Héctor Morán-Ordoñez Alejandra Villero Dani Guinart Daniel Brotons Lluís Hermoso Virgilio 《Biodiversity and Conservation》2022,31(4):1197-1215
Biodiversity and Conservation - Biodiversity keeps declining in the European Union despite the large conservation effort done over the last decades. The Biodiversity Strategy for 2030 aims to... 相似文献
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Richards EH Bradish H Dani MP Pietravalle S Lawson A 《Archives of insect biochemistry and physiology》2011,78(3):119-131
Although fungi are used to control a variety of insect pests, it is accepted that their usage could be increased if their efficacy was greater. The outcome of the interaction of a fungus and a pest insect may be influenced by a number of criteria, including the ability of the insect to mount effective immune responses against the pathogen. In view of this, we aimed to determine if a recombinant immunosuppressive wasp venom protein (rVPr1) can increase the susceptibility of larvae of the lepidopteran pest, Mamestra brassicae, to the fungal biological control agent, Beauveria bassiana. Bioassays indicated that when larvae were injected with 3.5 μl of rVPr1 and 100 B. bassiana conidia (combined injection assays), a significant reduction in survival of larvae occurred compared with each treatment on its own (P=0.006). Similar results were obtained when larvae were dipped in a solution containing 3 × 10(6) B. bassiana conidia per ml and then injected with 3.5 μl of rVPr1 2 days later (topical application assays), (P<0.001). These results indicate that rVPr1 can increase the efficacy of B. bassiana toward a lepidopteran pest, and are discussed within the context of insect immune responses and integrated pest management. 相似文献
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Lyons DM Huttunen KM Browne KA Ciccone A Trapani JA Denny WA Spicer JA 《Bioorganic & medicinal chemistry》2011,19(13):4091-4100
A high throughput screen showed the ability of a 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazole analogue to directly inhibit the lytic activity of the pore-forming protein perforin. A series of analogues were prepared to study structure-activity relationships (SAR) for the this activity, either directly added to cells or released in situ by KHYG-1 NK cells, at non-toxic concentrations. These studies showed that the pyridobenzimidazole moiety was required for effective activity, with strongly basic centres disfavoured. This class of compounds was relatively unaffected by the addition of serum, which was not the case for a previous class of direct inhibitors. 相似文献
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Hecht I Skoge ML Charest PG Ben-Jacob E Firtel RA Loomis WF Levine H Rappel WJ 《PLoS computational biology》2011,7(6):e1002044
Many eukaryotic cells are able to crawl on surfaces and guide their motility based on environmental cues. These cues are interpreted by signaling systems which couple to cell mechanics; indeed membrane protrusions in crawling cells are often accompanied by activated membrane patches, which are localized areas of increased concentration of one or more signaling components. To determine how these patches are related to cell motion, we examine the spatial localization of RasGTP in chemotaxing Dictyostelium discoideum cells under conditions where the vertical extent of the cell was restricted. Quantitative analyses of the data reveal a high degree of spatial correlation between patches of activated Ras and membrane protrusions. Based on these findings, we formulate a model for amoeboid cell motion that consists of two coupled modules. The first module utilizes a recently developed two-component reaction diffusion model that generates transient and localized areas of elevated concentration of one of the components along the membrane. The activated patches determine the location of membrane protrusions (and overall cell motion) that are computed in the second module, which also takes into account the cortical tension and the availability of protrusion resources. We show that our model is able to produce realistic amoeboid-like motion and that our numerical results are consistent with experimentally observed pseudopod dynamics. Specifically, we show that the commonly observed splitting of pseudopods can result directly from the dynamics of the signaling patches. 相似文献
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Laure-Emmanuelle Zaragosi Brigitte Wdziekonski Kevin Le Brigand Phi Villageois Bernard Mari Rainer Waldmann Christian Dani Pascal Barbry 《Genome biology》2011,12(7):R64
Background
In severe obesity, as well as in normal development, the growth of adipose tissue is the result of an increase in adipocyte size and numbers, which is underlain by the stimulation of adipogenic differentiation of precursor cells. A better knowledge of the pathways that regulate adipogenesis is therefore essential for an improved understanding of adipose tissue expansion. As microRNAs (miRNAs) have a critical role in many differentiation processes, our study aimed to identify the role of miRNA-mediated gene silencing in the regulation of adipogenic differentiation. 相似文献99.
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