全文获取类型
收费全文 | 7723篇 |
免费 | 715篇 |
国内免费 | 1篇 |
出版年
2023年 | 44篇 |
2022年 | 53篇 |
2021年 | 123篇 |
2020年 | 87篇 |
2019年 | 101篇 |
2018年 | 202篇 |
2017年 | 169篇 |
2016年 | 180篇 |
2015年 | 237篇 |
2014年 | 254篇 |
2013年 | 415篇 |
2012年 | 668篇 |
2011年 | 746篇 |
2010年 | 400篇 |
2009年 | 262篇 |
2008年 | 603篇 |
2007年 | 587篇 |
2006年 | 516篇 |
2005年 | 497篇 |
2004年 | 468篇 |
2003年 | 410篇 |
2002年 | 353篇 |
2001年 | 110篇 |
2000年 | 97篇 |
1999年 | 83篇 |
1998年 | 41篇 |
1997年 | 42篇 |
1996年 | 45篇 |
1995年 | 43篇 |
1994年 | 23篇 |
1993年 | 47篇 |
1992年 | 30篇 |
1991年 | 22篇 |
1990年 | 21篇 |
1989年 | 22篇 |
1988年 | 21篇 |
1987年 | 20篇 |
1986年 | 17篇 |
1985年 | 30篇 |
1984年 | 28篇 |
1983年 | 37篇 |
1982年 | 32篇 |
1981年 | 19篇 |
1980年 | 22篇 |
1979年 | 21篇 |
1978年 | 23篇 |
1977年 | 17篇 |
1976年 | 23篇 |
1975年 | 16篇 |
1974年 | 11篇 |
排序方式: 共有8439条查询结果,搜索用时 312 毫秒
101.
An extended conformation of sodium and calcium hyaluronate with helical parameters n (number of residues per turn) = 3 and h (axial rise per disaccharide) = 0.95 ± 0.01 nm has been found to pack in a number of two-dimensional arrays. Each of the structures exhibits a variant of a motif consisting of six chains surrounding a “vacant” site. The distribution of chains around this site, together with certain aspects of the periodicity, suggests that there might be a special relationship between this conformation of hyaluronic acid and water. 相似文献
102.
B.M. Fung David A. Wassil Dana L. Durham Robert W. Chesnut N.N. Durham K.D. Berlin 《Biochimica et Biophysica Acta (BBA)/General Subjects》1975,385(2)
The total water content, the amount of non-freezable water, and the Na+ and K+ contents in the gastrocnemius muscle of albino mice with and without a solid tumor were determined. The spin-lattice relaxation time (T1) for the water protons in the two kinds of muscle were measured at six resonance frequencies ranging from 4.5 to 60 MHz over the temperature range +37 to −65°C. Quantitatively calculated T1 values are given. The difference in T1 for the two types of muscle at temperatures above −5°C is attributed to the difference in the distribution ratio of water between hydration and free states, and bears no direct relation to the concentration of Na+. 相似文献
103.
Both substance-P and vasoactive intestinal peptide (VIP) have previously been demonstrated to contract and relax, respectively, the isolated guinea pig trachea. In addition, substance-P and VIP have been localized within the pulmonary innervation of various species. In the present studies, substance-P was found to cause a concentration-related contraction of isolated lung parenchymal strips of the guinea pig, as well as isolated tracheal strips. VIP caused a significant concentration-related relaxation of the isolated tracheal strip, but not the lung parenchymal strip. Indomethacin, a prostaglandin synthetase inhibitor, potentiated the contractile response of the trachea to substance-P and inhibited the VIP- and isoproterenol-induced relaxation. These studies are potentially important in understanding the pathogenesis of bronchospastic disorders, since alterations in prostaglandin biosynthesis may result in hyperreactivity of airways to contractile agonists such as neurotransmitters, as well as an inhibition of relaxation induced by endogenous substances such as VIP or β agonists. 相似文献
104.
105.
José Antonio González-Oreja Iriana Zuria Pilar Carbó-Ramírez Gregory Michaël Charre 《Biological invasions》2018,20(10):2861-2874
Quantifying the impacts that invasive alien species (IAS) cause on affected systems is not an easy task. Here, we explore the application of variation partitioning techniques to measure and control for the effects of possible confounding factors when studying the impact that feral pigeons, European starlings, and house sparrows cause on native urban bird communities in Mexico. We argue that these IAS are provoking a severe impact on whole assemblages of native passerines only if (a) their marginal effect is statistically significant, (b) it remains so after partialling out other explanatory variables, and (c) is larger than (or similar to) the conditional effect of these covariates. We censused passerine bird assemblages and measured habitat variables in a number of greenspaces in three replicate study areas. Then, by means of partial redundancy analyses, we decomposed the total variability in bird data as a function of IAS, physical variables and vegetation data. In one of the study areas the marginal effect of IAS on native assemblages was significant, but the conditional effect was not. We conclude that this IAS effect was confounded with other explanatory variables. In the other study areas, no (marginal or partial) significant effect was found. Without invoking interspecific competition, our results support the opportunistic hypothesis, according to which IAS can exploit ecological conditions in modern cities that native species cannot even tolerate. Finally, apart from the Precautionary Principle, we found no scientific justification to control the abundance of the three IAS in our study areas. 相似文献
106.
Emmanuël Sérusiaux Juan Carlos Villarreal A. Tim Wheeler Bernard Goffinet 《Journal of Biogeography》2011,38(6):1138-1151
Aim We reconstructed the phylogeny of the lichen genus Nephroma (Peltigerales) to assess the relationships of species endemic to Macaronesia. We estimated dates of divergences to test the hypothesis that the species arose in Macaronesia (neo‐endemism) versus the oceanic archipelagos serving as refugia for formerly widespread taxa (palaeo‐endemism). Location Cosmopolitan with a special focus on the archipelagos of the Azores, Madeira and the Canary Islands. Methods DNA sequences were obtained from 18 species for three loci and analysed using maximum parsimony, maximum likelihood and Bayesian inferences. Divergence dates were estimated for the internal transcribed spacer (ITS)‐based phylogeny using a relaxed molecular clock. Reconstruction of the ancestral geographical range was conducted using the Bayesian 50% majority rule consensus tree under a parsimony method. Results The backbone phylogenetic tree was fully supported, with Nephroma plumbeum as sister to all other species. Four strongly supported clades were detected: the Nephroma helveticum, the N. bellum, the N. laevigatum and the N. parile clades. The latter two share a common ancestor and each includes a widespread Holarctic species (N. laevigatum and N. parile, respectively) and all species endemic to Macaronesia. The data suggest a neo‐endemic origin of Macaronesian taxa, a recent range expansion from Macaronesia of both widespread species, a range expansion limited to the Mediteranean Basin and south‐western Europe for another taxon, and a long dispersal event that resulted in a speciation event in the western parts of North America. Main conclusions The Macaronesian endemic species belong to two sister clades and originated from a most recent common ancestor (MRCA) shared with one widely distributed taxon, either N. parile or N. laevigatum. Estimates of the mean divergence dates suggest that the endemics originated in the archipelagos after the rise of the volcanic islands, along with the ancestor to the now widespread species, which probably expanded their range beyond Macaronesia via long‐distance dispersal. This study provides the first phylogenetic evidence of Macaronesian neo‐endemism in lichenized fungi and provides support for the hypothesis that oceanic islands may serve as a source for the colonization of continents. However, further data are needed to properly assess the alternative hypothesis, namely colonization from western North America. 相似文献
107.
Eric M. Lind Elizabeth Borer Eric Seabloom Peter Adler Jonathan D. Bakker Dana M. Blumenthal Mick Crawley Kendi Davies Jennifer Firn Daniel S. Gruner W. Stanley Harpole Yann Hautier Helmut Hillebrand Johannes Knops Brett Melbourne Brent Mortensen Anita C. Risch Martin Schuetz Carly Stevens Peter D. Wragg 《Ecology letters》2013,16(4):513-521
Plant growth can be limited by resource acquisition and defence against consumers, leading to contrasting trade‐off possibilities. The competition‐defence hypothesis posits a trade‐off between competitive ability and defence against enemies (e.g. herbivores and pathogens). The growth‐defence hypothesis suggests that strong competitors for nutrients are also defended against enemies, at a cost to growth rate. We tested these hypotheses using observations of 706 plant populations of over 500 species before and following identical fertilisation and fencing treatments at 39 grassland sites worldwide. Strong positive covariance in species responses to both treatments provided support for a growth‐defence trade‐off: populations that increased with the removal of nutrient limitation (poor competitors) also increased following removal of consumers. This result held globally across 4 years within plant life‐history groups and within the majority of individual sites. Thus, a growth‐defence trade‐off appears to be the norm, and mechanisms maintaining grassland biodiversity may operate within this constraint. 相似文献
108.
E Laplantine E Fontan J Chiaravalli T Lopez G Lakisic M Véron F Agou Alain Israël 《The EMBO journal》2009,28(19):2885-2895
An important property of NEMO, the core element of the IKK complex involved in NF‐κB activation, resides in its ability to specifically recognize poly‐ubiquitin chains. A small domain called NOA/UBAN has been suggested to be responsible for this property. We recently demonstrated that the C‐terminal Zinc Finger (ZF) of NEMO is also able to bind ubiquitin. We show here by ZF swapping and mutagenesis that this represents its only function. While neither NOA nor ZF shows any preference for K63‐linked chains, we demonstrate that together they form a bipartite high‐affinity K63‐specific ubiquitin‐binding domain. A similar domain can be found in two other proteins, Optineurin and ABIN2, and can be freely exchanged with that of NEMO without interfering with its activity. This suggests that the main function of the C‐terminal half of NEMO is to specifically bind K63‐linked poly‐ubiquitin chains. We also demonstrate that the recently described binding of NEMO to linear poly‐ubiquitin chains is dependent on the NOA alone and does not require the presence of the ZF. 相似文献
109.
110.
To be effective, signals must propagate through the environment and be detected by receivers. As a result, signal form evolves in response to both the constraints imposed by the transmission environment and receiver perceptual abilities. Little work has examined the extent to which signals may act as selective forces on receiver sensory systems to improve the efficacy of communication. If receivers benefit from accurate signal assessment, selection could favour sensory organs that improve discrimination of established signals. Here, we provide evidence that visual resolution coevolves with visual signals in Polistes wasps. Multiple Polistes species have variable facial patterns that function as social signals, whereas other species lack visual signals. Analysis of 19 Polistes species shows that maximum eye facet size is positively associated with both eye size and presence of visual signals. Relatively larger facets within the eye''s acute zone improve resolution of small images, such as wasp facial signals. Therefore, sensory systems may evolve to optimize signal assessment. Sensory adaptations to facilitate signal detection may represent an overlooked area of the evolution of animal communication. 相似文献