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91.
92.
Ricardas Radisauskas Vilija Malinauskiene Egle Milinaviciene Daina Kranciukaite-Butylkiniene Abdonas Tamosiunas Gailute Bernotiene Dalia Luksiene Zemyna Milasauskiene Diana Sopagiene Daiva Rastenyte 《PloS one》2016,11(4)
BackgroundThere is a lack of reliable epidemiological data on longitudinal trends in stroke attack rates, incidence, and mortality in the countries of the Baltic region.AimsThe aim of the present study was to explore the longitudinal trends of stroke in middle-aged urban population of Lithuania during the period of 1986 through 2012.MethodsAll stroke events in the studied population were ascertained and validated according to the standardized criteria outlined by the WHO MONICA Project. The study included all patients in Kaunas (Lithuania) city aged 25 to 64 years who experienced a stroke between 1986 and 2012. Estimates of time-trends of the annual percentage change in stroke attack rates, incidence of stroke, and mortality from this condition were made by applying the Joinpoint regression analysis.ResultsDuring the study period, 9,992 stroke events were registered. The overall proportion of recurrent events was 25.7%. Overall, 18.9% of the events (20.0% in men, and 17.4% in women) were fatal within 28 days. During the period of 1986 to 2012, a flat trend in the incidence of stroke was observed among both male and female middle-aged inhabitants of Kaunas city, while attack rates were increasing due to the increase in recurrent strokes. Both mortality and 28-day case fatality of stroke declined significantly over the study period in both sexes.ConclusionsAn increase both in the incidence and recurrence of stroke among middle-aged men residing in Kaunas city and in the recurrence of stroke among women denotes the inefficiency of measures applied both for primary and secondary prevention of stroke in Lithuania. The revision of current prevention strategies and the introduction of new ones are of paramount importance in order to fight the epidemic of stroke. 相似文献
93.
Meligy Fatma Y. Elgamal Dalia A. Abd Allah Eman S. H. Idriss Naglaa K. Ghandour Nagwa M. Bayoumy Ehab M. R. Khalil Azza Sayed Abdelrehim El Fiky Mohamed M. Elkhashab Mostafa 《Molecular biology reports》2019,46(6):5841-5858
Molecular Biology Reports - Parkinson’s disease (PD) is a chronic neurodegenerative disease. Unfortunately, the effectiveness of anti-Parkinson treatments gradually diminishes owing to the... 相似文献
94.
Differential expression of cucumber RNA‐dependent RNA polymerase 1 genes during antiviral defence and resistance 下载免费PDF全文
95.
Benzofurazan‐based fluorophore for the selective determination of flupentixol dihydrochloride: Application to content uniformity testing 下载免费PDF全文
One of the most commonly used drugs in treatment of schizophrenia is flupentixol dihydrochloride, therefore it is important to develop a simple, low cost and sensitive spectrofluorimetric method for the estimation of flupentixol dihydrochloride. The yellow fluorescent product that is generated from the nucleophilic substitution reaction of the free lone pair of the alcoholic hydroxyl group of the drug and 4‐chloro‐7‐nitrobenzofurazan (NBD‐Cl) in Mcllvaine buffer pH 7.0 was estimated at 510 nm (λex 460 nm). The variables that affect the development of the reaction product were explored and optimized. The linear range of this method was 0.5–2.5 μg ml?1 with a limit of quantitation equal to 0.29 μg ml?1. Our method was successfully applied for the assurance of flupentixol in tablet form with average percentage recovery of 99.08 ± 1.01% without obstruction from the basic excipients exhibits. Furthermore, our strategy was extended to study the content uniformity testing of flupentixol in Fluaxnol® tablets. 相似文献
96.
Dalia Ali Farghaly Ahmed A. Aboelwafa Manal Y. Hamza Magdy I. Mohamed 《Journal of liposome research》2018,28(2):126-136
The aim of this study was to investigate microemulsion (ME) based topical delivery system for fenoprofen calcium (FPCa) to eliminate its oral gastrointestinal adverse effects. ME was prepared by the water titration method using oleic acid as oil phase, tween 80 as a surfactant and propylene glycol as a cosurfactant. Oleic acid was selected as oil phase due to its good solubilizing capacity. ME existence region was determined using pseudo-ternary phase diagrams for preparing different formulations. Six different formulations were selected with various values of oil (25–68%), water (2–3%), and the mixture of surfactant and cosurfactant (1:1) (24–67%). The selected ME formulae were characterized for optical birefringence, transmission electron microscopy (TEM), pH, % transmittance, electronic conductivity, drug content, droplet size, rheological properties and stability evaluation. In vitro release study of FPCa from ME s through the synthetic membrane and hairless rat skin were evaluated. The optimized formula ME5 consisting of 5% w/w FPCa, 60% w/w oleic acid as oil phase, 3% w/w aqueous phase, and 32% w/w of surfactant phase containing Tween 80 and propylene glycol (1:?1) showed the highest transdermal flux and highest skin permeation rate. Finally, the % inhibition of carrageenan-induced rat paw edema of the optimized formula ME5 was highly significant (p?0.001) as compared to plain gel of FPCa. In conclusion, ME is a promising technique for topical delivery of FPCa. 相似文献
97.
98.
Dalia Gordon 《Invertebrate neuroscience : IN》1997,3(2-3):103-116
Voltage-sensitive sodium channels are responsible for the generation of electrical signals in most excitable tissues and serve
as specific targets for many neurotoxins. At least seven distinct classes of neurotoxins have been designated on the basis
of physiological activity and competitive binding studies. Although the characterization of the neurotoxin receptor sites
was predominantly performed using vertebrate excitable preparations, insect neuronal membranes were shown to possess similar
receptor sites. We have demonstrated that the two mutually competing antiinsect excitatory and depressant scorpion toxins,
previously suggested to occupy the same receptor site, bind to two distinct receptors on insect sodium channels. The latter
provides a new approach to their combined use in insect control strategy. Although the sodium channel receptor sites are topologically
separated, there are strong allosteric interactions among them. We have shown that the lipid-soluble sodium channel activators,
veratridine and brevetoxin, reveal divergent allosteric modulation on scorpion α-toxins binding at homologous receptor sites
on mammalian and insect sodium channels. The differences suggest a functionally important structural distinction between these
channel subtypes. The differential allosteric modulation may provide a new approach to increase selective activity of pesticides
on target organisms by simultaneous application of allosterically interacting drugs, designed on the basis of the selective
toxins. Thus, a comparative study of neurotoxin receptor sites on mammalian and invertebrate sodium channels may elucidate
the structural features involved in the binding and activity of the various neurotoxins, and may offer new targets and approaches
to the development of highly selective pesticides. 相似文献
99.
100.
Validated spectrofluorimetric method for determination of two phosphodiesterase inhibitors tadalafil and vardenafil in pharmaceutical preparations and spiked human plasma 下载免费PDF全文
Mohammed Abu Bakr Abu El‐Enin Mohammed El‐Sayed Abd Al‐Ghaffar Hammouda Dina Tawfik El‐Sherbiny Dalia Rashad El‐Wasseef Saadia Mahmoud El‐Ashry 《Luminescence》2016,31(1):173-178
A valid, sensitive and rapid spectrofluorimetric method has been developed and validated for determination of both tadalafil (TAD) and vardenafil (VAR) either in their pure form, in their tablet dosage forms or spiked in human plasma. This method is based on measurement of the native fluorescence of both drugs in acetonitrile at λem 330 and 470 nm after excitation at 280 and 275 nm for tadalafil and vardenafil, respectively. Linear relationships were obtained over the concentration range 4–40 and 10–250 ng/mL with a minimum detection of 1 and 3 ng/mL for tadalafil and vardenafil, respectively. Various experimental parameters affecting the fluorescence intensity were carefully studied and optimized. The developed method was applied successfully for the determination of tadalafil and vardenafil in bulk drugs and tablet dosage forms. Moreover, the high sensitivity of the proposed method permitted their determination in spiked human plasma. The developed method was validated in terms of specificity, linearity, lower limit of quantification (LOQ), lower limit of detection (LOD), precision and accuracy. The mean recoveries of the analytes in pharmaceutical preparations were in agreement with those obtained from the comparison methods, as revealed by statistical analysis of the obtained results using Student's t‐test and the variance ratio F‐test. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献