全文获取类型
收费全文 | 2618篇 |
免费 | 308篇 |
国内免费 | 1篇 |
专业分类
2927篇 |
出版年
2021年 | 48篇 |
2020年 | 26篇 |
2019年 | 24篇 |
2018年 | 29篇 |
2017年 | 35篇 |
2016年 | 51篇 |
2015年 | 110篇 |
2014年 | 115篇 |
2013年 | 105篇 |
2012年 | 145篇 |
2011年 | 169篇 |
2010年 | 91篇 |
2009年 | 71篇 |
2008年 | 101篇 |
2007年 | 111篇 |
2006年 | 106篇 |
2005年 | 108篇 |
2004年 | 98篇 |
2003年 | 91篇 |
2002年 | 104篇 |
2001年 | 56篇 |
2000年 | 53篇 |
1999年 | 40篇 |
1998年 | 43篇 |
1997年 | 35篇 |
1996年 | 33篇 |
1995年 | 35篇 |
1994年 | 40篇 |
1993年 | 40篇 |
1992年 | 29篇 |
1991年 | 47篇 |
1990年 | 38篇 |
1989年 | 36篇 |
1988年 | 23篇 |
1987年 | 31篇 |
1986年 | 34篇 |
1985年 | 40篇 |
1984年 | 34篇 |
1983年 | 31篇 |
1982年 | 21篇 |
1981年 | 29篇 |
1980年 | 34篇 |
1979年 | 23篇 |
1978年 | 29篇 |
1977年 | 25篇 |
1975年 | 30篇 |
1974年 | 23篇 |
1973年 | 25篇 |
1971年 | 19篇 |
1970年 | 19篇 |
排序方式: 共有2927条查询结果,搜索用时 15 毫秒
81.
A meta-analysis of elevated [CO2 ] effects on soybean (Glycine max) physiology, growth and yield 总被引:7,自引:2,他引:7
Elizabeth A. Ainsworth Phillip A. Davey Carl J. Bernacchi Orla C. Dermody Emily A. Heaton David J. Moore Patrick B. Morgan Shawna L. Naidu Hyung-shim Yoo Ra Xin-guang Zhu Peter S. Curtis Stephen P. Long 《Global Change Biology》2002,8(8):695-709
The effects of elevated [CO2] on 25 variables describing soybean physiology, growth and yield are reviewed using meta‐analytic techniques. This is the first meta‐analysis to our knowledge performed on a single crop species and summarizes the effects of 111 studies. These primary studies include numerous soybean growth forms, various stress and experimental treatments, and a range of elevated [CO2] levels (from 450 to 1250 p.p.m.), with a mean of 689 p.p.m. across all studies. Stimulation of soybean leaf CO2 assimilation rate with growth at elevated [CO2] was 39%, despite a 40% decrease in stomatal conductance and a 11% decrease in Rubisco activity. Increased leaf CO2 uptake combined with an 18% stimulation in leaf area to provide a 59% increase in canopy photosynthetic rate. The increase in total dry weight was lower at 37%, and seed yield still lower at 24%. This shows that even in an agronomic species selected for maximum investment in seed, several plant level feedbacks prevent additional investment in reproduction, such that yield fails to reflect fully the increase in whole plant carbon uptake. Large soil containers (> 9 L) have been considered adequate for assessing plant responses to elevated [CO2]. However, in open‐top chamber experiments, soybeans grown in large pots showed a significant threefold smaller stimulation in yield than soybeans grown in the ground. This suggests that conclusions about plant yield based on pot studies, even when using very large containers, are a poor reflection of performance in the absence of any physical restriction on root growth. This review supports a number of current paradigms of plant responses to elevated [CO2]. Namely, stimulation of photosynthesis is greater in plants that fix N and have additional carbohydrate sinks in nodules. This supports the notion that photosynthetic capacity decreases when plants are N‐limited, but not when plants have adequate N and sink strength. The root : shoot ratio did not change with growth at elevated [CO2], sustaining the charge that biomass allocation is unaffected by growth at elevated [CO2] when plant size and ontogeny are considered. 相似文献
82.
Background
Proportions derived from neoclassical canons, initially described by Renaissance sculptors and painters, are still being employed as aesthetic guidelines during the clinical assessment of the facial morphology.Objective
1. to determine the applicability of neoclassical canons for Southern Chinese faces and 2. to explore gender differences in relation to the applicability of the neoclassical canons and their variants.Methodology
3-D photographs acquired from 103 young adults (51 males and 52 females) without facial dysmorphology were used to test applicability of four neoclassical canons. Standard anthropometric measurements that determine the facial canons were made on these 3-D images. The validity of the canons as well as their different variants were quantified.Principal Findings
The neoclassical cannons seldom applied to these individuals, and facial three-section and orbital canons did not apply at all. The orbitonasal canon was most frequently applicable, with a frequency of 19%. Significant sexual dimorphism was found relative to the prevalence of the variants of facial three-section and orbitonasal canons.Conclusion
The neoclassical canons did not appear to apply to our sample when rigorous quantitative measurements were employed. Thus, they should not be used as esthetic goals for craniofacial surgical interventions. 相似文献83.
84.
Influence of BCG vaccine strain on the immune response and protection against tuberculosis 总被引:3,自引:0,他引:3
The Bacille Calmette–Guérin (BCG) vaccine has been used for more than 80 years to protect against tuberculosis. Worldwide, over 90% of children are immunized with BCG, making it the most commonly administered vaccine, with more than 120 million doses used each year. Although new tuberculosis vaccines are under investigation, BCG will remain the cornerstone of the strategy to fight the worsening tuberculosis pandemic for the foreseeable future. The recent delineation of genetic differences between BCG vaccine strains has renewed interest in the influence of the vaccine strain on the protective efficacy against tuberculosis. This review critically examines the data from animal and human studies comparing BCG vaccine strains. Although there is good evidence to support the notion that the induced immune response and protection afforded against tuberculosis differs between BCG vaccine strains, currently, there are insufficient data to favour or recommend one particular strain. Identifying BCG strains with superior protection would have a dramatic effect on tuberculosis control at a population level: a small increment in protection provided by BCG immunization will prevent large numbers of cases of severe tuberculosis and deaths, particularly in children. 相似文献
85.
Claire M. Waluda Michael J. Dunn Michael L. Curtis Peter T. Fretwell 《Polar Biology》2014,37(12):1849-1855
Changes in penguin abundance and distribution can be used to understand the response of species to climate change and fisheries pressures, and as a gauge of ecosystem health. Traditionally, population estimates have involved direct counts, but remote sensing and digital mapping methodologies can provide us with alternative techniques for assessing the size and distribution of penguin populations. Here, we demonstrate the use of a field-based digital mapping system (DMS), combining a handheld geographic information system with integrated geographical positioning system as a method for: (a) assessing penguin colony area and (b) ground-truthing colony area as derived from satellite imagery. Work took place at Signy Island, South Orkneys, where colonies of the three congeneric pygoscelid penguins: Adélie Pygoscelis adeliae, chinstrap P. antarctica and gentoo P. papua were surveyed. Colony areas were derived by mapping colony boundaries using the DMS with visual counts of the number of nesting birds made concurrently. Area was found to be a good predictor for number of nests for all three species of penguin. Using a maximum likelihood multivariate classification of remotely sensed satellite imagery (QuickBird2, 18 January 2010; Digital Globe ID: 01001000B90AD00), we were able to identify penguin colonies from the spectral signature of guano and differentiate between colonies of Adélie and chinstrap penguins. The area classified (all species combined) from satellite imagery versus area from DMS data was closely related (R 2 = 0.88). Combining these techniques gives a simple and transferrable methodology for examining penguin distribution and abundance at local and regional scales. 相似文献
86.
King KC Jokela J Lively CM 《Evolution; international journal of organic evolution》2011,65(5):1474-1481
Under the Red Queen hypothesis, host-parasite coevolution selects against common host genotypes. Although this mechanism might underlie the persistence of sexual reproduction, it might also maintain high clonal diversity. Alternatively, clonal diversity might be maintained by multiple origins of parthenogens from conspecific sexuals, a feature in many animal groups. Herein, we addressed the maintenance of overall genetic diversity by coevolving parasites, as predicted by the Red Queen hypothesis. We specifically examined the contribution of parasites to host clonal diversity and the frequency of sexually reproducing individuals in natural stream populations of Potamopyrgus antipodarum snails. We also tested the alternative hypothesis that clonal diversity is maintained by the input of clones by mutation from sympatric sexuals. Clonal diversity and the frequency of sexual individuals were both positively related to infection frequency. Surprisingly, although clones are derived by mutation from sexual snails, parasites explained more of the genotypic variation among parthenogenetic subpopulations. Our findings thus highlight the importance of parasites as drivers of clonal diversity, as well as sex. 相似文献
87.
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance 下载免费PDF全文
Lelliott CJ Medina-Gomez G Petrovic N Kis A Feldmann HM Bjursell M Parker N Curtis K Campbell M Hu P Zhang D Litwin SE Zaha VG Fountain KT Boudina S Jimenez-Linan M Blount M Lopez M Meirhaeghe A Bohlooly-Y M Storlien L Strömstedt M Snaith M Oresic M Abel ED Cannon B Vidal-Puig A 《PLoS biology》2006,4(11):e369
88.
Savall BM Gomez L Chavez F Curtis M Meduna SP Kearney A Dunford P Cowden J Thurmond RL Grice C Edwards JP 《Bioorganic & medicinal chemistry letters》2011,21(21):6577-6581
This report discloses the development of a series of tricyclic histamine H(4) receptor antagonists. Starting with a low nanomolar benzofuranopyrimidine HTS hit devoid of pharmaceutically acceptable properties, we navigated issues with metabolism and solubility to furnish a potent, stable and water soluble tricyclic histamine H(4) receptor antagonist with desirable physiochemical parameters which demonstrated efficacy a mouse ova model. 相似文献
89.
Nucleotide sequence of mouse 5-aminolevulinic acid synthase cDNA and expression of its gene in hepatic and erythroid tissues 总被引:21,自引:0,他引:21
The cDNA coding for 5-aminolevulinic acid (ALA) synthase (EC 2.3.1.37) in both liver and anemic spleen of the mouse has been cloned. The liver clone was selected by complementation of an Escherichia coli hemA mutant. Erythroid clones were obtained by screening a cDNA library made from mouse anemic spleen RNA, using the liver cDNA as a probe. The sequences of the spleen-derived and liver-derived cDNAs are identical. The nucleotide sequence and predicted amino acid (aa) sequence of a 1.85-kb spleen-derived cDNA is presented. The mouse ALA synthase as sequence displays extensive homology to ALA synthase of chick embryonic liver. The ALA synthase mRNA, detected by Northern blot analysis, was the same size, approx. 2.3 kb, in mouse liver, anemic spleen, and mouse erythroleukemia cells. It is therefore unlikely that different isozymic forms of ALA synthase are present in mouse erythroid and hepatic tissue and this is not the basis for the different effects of heme and porphyrinogenic compounds on the expression of liver and erythroid ALA synthase. 相似文献
90.
Johnson CN 《Journal of the history of biology》2007,40(3):529-556
Almost any modern reader’s first encounter with Darwin’s writing is likely to be the “Historical Sketch,” inserted by Darwin
as a preface to an early edition of the Origin of Species, and having since then appeared as the preface to every edition after the second English edition. The Sketch was intended
by him to serve as a short “history of opinion” on the species question before he presented his own theory in the Origin proper. But the provenance of the “Historical Sketch” is somewhat obscure. Some things are known about its production, such
as when it first appeared and what changes were made to it between its first appearance in 1860 and its final form, for the
fourth English edition, in 1866. But how it evolved in Darwin’s mind, why he wrote it at all, and what he thought he was accomplishing
by prefacing it to the Origin remain questions that have not been carefully addressed in the scholarly literature on Darwin. I attempt to show that Darwin’s
various statements about the “Historical Sketch,” made primarily to several of his correspondents between 1856 and 1860, are
somewhat in conflict with one another, thus making problematic a satisfactory interpretation of how, when, and why the Sketch
came to be. I also suggest some probable resolutions to the several difficulties.
How Darwin came to settle on the title “Historical Sketch” for the Preface to the Origin is not certain, but a guess may be ventured. When he first submitted the text to Asa Gray in February 1860 he called it simply
“Preface Contributed by the Author to this American Edition” (Burkhardt et al., eds., vol. 8, 1993, p. 572; the collected
correspondence is hereafter cited as CCD). In fact he had thought of it as being properly called a Preface much earlier, perhaps as early as 1856, as will be seen
in what follows. It came to be called “An Historical Sketch of the Recent Progress of Opinion on the Origin of Species” only
in the third English edition, April 1861. This is the title it retained thereafter, with the exception of an addition to the
title in the sixth English edition, “Previously to the Publication of the First Edition of this Work” (Peckham, 1959, pp. 20, 59). The word “sketch,” on the other hand was one of two words Darwin commonly used in private correspondence to
refer to the book that would later become the Origin, the other word being “Abstract,” and both signifying that Darwin thought of the work as being a resume rather than a full-fledged
study (e.g., letter to J.D. Hooker, May 9 1856, CCD vol. 6 p. 106; letter to Baden Powell January 18 1860, CCD vol. 8 p. 41; letter to Lyell 25 June 1858, CCD v. 7, 1991, pp. 117–8; letter to Lyell May 1856, CCD, v. 6 p. 100). The most likely source of the title “Historical Sketch” for Darwin’s Preface is Charles Lyell’s Principles of Geology in which, beginning with the third edition (1834), Lyell added titles to his chapters, calling chapters 2–4 “Historical Sketch
of the Progress of Geology” (Secord, in Lyell [1997], p. xlvii; for other uses by Lyell of this expression, cf. Porter, 1976, p. 95; idem 1982, p. 38; and Lyell, 1830 [1990], p. 30). Further parallels between Lyell’s Introduction and Darwin’s “Historical Sketch” in terms of content and strategy
are suggested below. 相似文献