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North Africa has undergone drastic climatic changes over the past several hundred thousand years. The timing of humid intervals called pluvials was investigated by uranium-series disequilibrium dating of travertines from the Kurkur Oasis, Western Desert, Egypt. The youngest and best dated travertines (70–160 ka) are found in Wadi Kurkur and include spring and lacustrine units exposed as 2 to 3 m high terraces. Travertines having an age of approximately 191–220 ka are exposed by differential erosion as linear mounds produced by spring systems over fracture zones in ancient wadis. The oldest travertines, having ages >260 ka, are extensive, cap limestone units above the oasis, and were deposited in paludal and lacustrine environments. Oxygen isotope ratios were measured for the wadi travertines (δ18O values ranging from 16.7 to 19.1‰ SMOW) and for spring mound travertines (18.5–20.5‰). Equilibrium oxygen isotope fractionation calculations indicate that the Kurkur travertines were deposited from waters having δ18O values similar to ancient Western Desert groundwaters ( −11‰, Sonntag et al., 1978a,b; Thorweithe, 1990; Sultan et al., 1996). The ages of the travertines correspond to times of monsoonal maxima, eustatic sea level high stands and interglacial maxima. Rainfall producing these groundwaters (and travertines) was significantly fractionated during atmospheric transport, in contrast to modern meteoric waters (−2.09‰, Joseph et al., 1992), implying a distant source for the pluvial waters. Increased precipitation, recharge of Western Desert groundwaters, and resultant travertine deposition are interpreted to be consequences of Milankovitch insolation cycle forcing, through enhanced Atlantic and Indian Ocean monsoons during interglacial time periods.  相似文献   
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A postal questionnaire study was carried out in an urban general practice to determine the effect of the introductory letter being sent by the participants'' own general practitioner compared with that from a letter sent directly from a research unit. By sequential sampling 409 individuals aged between 40 and 59 were assigned to one of two groups. The people in one group were written to by their own general practitioner and those in the other by a doctor from a research unit. Husbands and wives were paired and were always sent the same letter. A second letter was sent to nonresponders after one month. The response rate to the general practitioner was significantly higher than that to the doctor in the research unit (85% compared with 75%) and differed by age and sex. The results have important implications for other research workers and suggest that general practitioners are in a key position in the conduct of medical and epidemiological research.  相似文献   
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