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241.
Keren Tazat Leslie Pomeraniec-Abudy Melissa Hector-Greene Szabina Szfia Szilgyi Swati Sharma Elise M. Cai Armando L. Corona Marcelo Ehrlich Gerard C. Blobe Yoav I. Henis 《Molecular biology of the cell》2021,32(7):605
Complex formation and endocytosis of transforming growth factor-β (TGF-β) receptors play important roles in signaling. However, their interdependence remained unexplored. Here, we demonstrate that ALK1, a TGF-β type I receptor prevalent in endothelial cells, forms stable complexes at the cell surface with endoglin and with type III TGF-β receptors (TβRIII). We show that ALK1 undergoes clathrin-mediated endocytosis (CME) faster than ALK5, type II TGF-β receptor (TβRII), endoglin, or TβRIII. These complexes regulate the endocytosis of the TGF-β receptors, with a major effect mediated by ALK1. Thus, ALK1 enhances the endocytosis of TβRIII and endoglin, while ALK5 and TβRII mildly enhance endoglin, but not TβRIII, internalization. Conversely, the slowly endocytosed endoglin has no effect on the endocytosis of either ALK1, ALK5, or TβRII, while TβRIII has a differential effect, slowing the internalization of ALK5 and TβRII, but not ALK1. Such effects may be relevant to signaling, as BMP9-mediated Smad1/5/8 phosphorylation is inhibited by CME blockade in endothelial cells. We propose a model that links TGF-β receptor oligomerization and endocytosis, based on which endocytosis signals are exposed/functional in specific receptor complexes. This has broad implications for signaling, implying that complex formation among various receptors regulates their surface levels and signaling intensities. 相似文献
242.
243.
Evolution of androgen-regulated mRNA expression in mouse kidney 总被引:1,自引:0,他引:1
To gain information on the evolution of mammalian gene expression patterns,
we studied the androgen-inducible expression of three kidney mRNAs in
several mouse species (genus Mus). The RP2, ornithine decarboxylase, and
beta-glucuronidase mRNAs have each evolved independently, in that the
pattern of variation among species is unique for each. This suggests a role
for gene-specific, cis-acting genetic elements. Relationships between the
regulatory phenotypes and the species phylogeny suggest that the variations
in hormone-inducible mRNA expression were generated by a series of
independent mutations that occurred in specific lineages, resulting in
modifications of the progenitor phenotype. Alternatively, the variations
may have preexisted within the progenitor population as polymorphisms that
were fixed during establishment of individual lineages. Thus, significant
alterations in the androgen-regulated mRNA phenotype have occurred either
prior to or during speciation within the Mus genus. These alterations are
presumed to be in regulatory sequences that control the expression of the
corresponding genes and their response to testosterone; as such, they
should be useful in further studying the genetic determinants of gene
expression and its evolution.
相似文献
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Elisa Bigliardi Maria Giovanna Riparbelli Maria Gloria Selmi Paolo Lanzarini Silvia Corona Simonetta Gatti Massimo Scaglia Luciano Sacchi 《The Journal of eukaryotic microbiology》1998,45(3):347-351
The mitotic process in microsporidian Encephalitozoon hellem. a known human pathogen, has been studied with the aim of elucidating some ultrastructural aspects of its nuclear division. The presence of a nuclear spindle, of "electrondense spindle plaques" associated with the nuclear envelope and of cytoplasmic double walled vesicles are reported. We suggest that these "electrondense spindle plaques" serve as foci for intranuclear and cytoplasmic microtubule arrangements, similar to the microtubule organizing centers within the centrosomes of animal cells. The extent to which the microsporidial division process is comparable with that of more familiar eukaryotes such as yeast cells is discussed. 相似文献
246.
G Budetta A Crasto M Corona G Colella 《Bollettino della Società italiana di biologia sperimentale》1991,67(2):123-128
The lingual and papillary mucosa innervation has been studied in the buffalo by histochemical and immunohistochemical techniques and by gold impregnation method of Ruffini. In lingual mucosa the presence of ganglionic structures has been noticed in which there are numerous cellular bodies and bundles of fibres variously directed. Particularly in the vallate papillae, the papillary stroma contains myelinic and unmyelinated fibres and terminal nerve corpuscles. Along stromal myelinic fibres the presence of the proteins S-100 and NF has been demonstrated. 相似文献
247.
248.
Use of pyridoxine hydrochloride in the interruption of lactation in female dogs with pseudopregnancy
Maíra Corona da Silva Paula Elisa Brando Guedes Fabiana Lessa Silva Paola Pereira das Neves Snoeck 《Animal Reproduction》2021,18(1)
The aim of this research was to evaluate the use of pyridoxine hydrochloride and its associated side effects in the treatment of pseudopregnancy in female dogs. A total of 40 female dogs, with no defined breed, in non-gestational diestrus, with clinical complaint of milk production were selected. The female dogs were divided into four experimental groups of 10 animals each, treated orally for 20 days with 10mg/kg/day (G1) and 50mg/kg/day (G2) of pyridoxine hydrochloride (vitamin B6), 5μg/kg/day of cabergoline (G3), and with a placebo, in the case of the control group (G4). The effects of the treatments on milk production were investigated, as well as possible systemic side effects, macroscopic uterine and ovarian alterations, and uterine histology. During the investigated period, G2 and G3 were equally efficient (P>0.05) in lactation suppression, differing (P>0.05) from the other groups. There were no systemic side effects or uterine changes associated with administration of the studied drug. Vitamin B6 (50mg/kg) has shown to be a safe and economically viable alternative for lactation interruption in female dogs with pseudopregnancy. 相似文献
249.
Detection of β‐exotoxin synthesis in Bacillus thuringiensis using an easy bioassay with the nematode Caenorhabditis elegans 下载免费PDF全文
250.