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71.
Corentin M. Barbu Karthik Sethuraman Erica M. W. Billig Michael Z. Levy 《Ecography》2018,41(4):661-672
Biological invasions reshape environments and affect the ecological and economic welfare of states and communities. Such invasions advance on multiple spatial scales, complicating their control. When modeling stochastic dispersal processes, intractable likelihoods and autocorrelated data complicate parameter estimation. As with other approaches, the recent synthetic likelihood framework for stochastic models uses summary statistics to reduce this complexity; however, it additionally provides usable likelihoods, facilitating the use of existing likelihood‐based machinery. Here, we extend this framework to parameterize multi‐scale spatio‐temporal dispersal models and compare existing and newly developed spatial summary statistics to characterize dispersal patterns. We provide general methods to evaluate potential summary statistics and present a fitting procedure that accurately estimates dispersal parameters on simulated data. Finally, we apply our methods to quantify the short and long range dispersal of Chagas disease vectors in urban Arequipa, Peru, and assess the feasibility of a purely reactive strategy to contain the invasion. 相似文献
72.
Patrice E. Fort Mandy K. Losiewicz Lynda Elghazi Dejuan Kong Corentin Cras-Mneur Diane C. Fingar Scot R. Kimball Raju V.S. Rajala Alexander J. Smith Robin R. Ali Steven F. Abcouwer Thomas W. Gardner 《The Journal of biological chemistry》2022,298(6)
Mechanistic target of rapamycin (mTOR) and mTOR complex 1 (mTORC1), linchpins of the nutrient sensing and protein synthesis pathways, are present at relatively high levels in the ganglion cell layer (GCL) and retinal ganglion cells (RGCs) of rodent and human retinas. However, the role of mTORCs in the control of protein synthesis in RGC is unknown. Here, we applied the SUrface SEnsing of Translation (SUnSET) method of nascent protein labeling to localize and quantify protein synthesis in the retinas of adult mice. We also used intravitreal injection of an adeno-associated virus 2 vector encoding Cre recombinase in the eyes of mtor- or rptor-floxed mice to conditionally knockout either both mTORCs or only mTORC1, respectively, in cells within the GCL. A novel vector encoding an inactive Cre mutant (CreΔC) served as control. We found that retinal protein synthesis was highest in the GCL, particularly in RGC. Negation of both complexes or only mTORC1 significantly reduced protein synthesis in RGC. In addition, loss of mTORC1 function caused a significant reduction in the pan-RGC marker, RNA-binding protein with multiple splicing, with little decrease of the total number of cells in the RGC layer, even at 25 weeks after adeno-associated virus-Cre injection. These findings reveal that mTORC1 signaling is necessary for maintaining the high rate of protein synthesis in RGCs of adult rodents, but it may not be essential to maintain RGC viability. These findings may also be relevant to understanding the pathophysiology of RGC disorders, including glaucoma, diabetic retinopathy, and optic neuropathies. 相似文献
73.
Mnica VaraPrez Matteo Rossi Chris Van den Haute Hannelore Maes Maria Livia Sassano Vivek Venkataramani Bernhard Michalke Erminia Romano Kristine Rillaerts Abhishek D Garg Corentin Schepkens Francesca M Bosisio Jasper Wouters Ana Isabel Oliveira Peter Vangheluwe Wim Annaert Johannes V Swinnen Jean Marie Colet Joost J van den Oord SarahMaria Fendt Massimiliano Mazzone Patrizia Agostinis 《The EMBO journal》2021,40(10)
BNIP3 is a mitophagy receptor with context‐dependent roles in cancer, but whether and how it modulates melanoma growth in vivo remains unknown. Here, we found that elevated BNIP3 levels correlated with poorer melanoma patient’s survival and depletion of BNIP3 in B16‐F10 melanoma cells compromised tumor growth in vivo. BNIP3 depletion halted mitophagy and enforced a PHD2‐mediated downregulation of HIF‐1α and its glycolytic program both in vitro and in vivo. Mechanistically, we found that BNIP3‐deprived melanoma cells displayed increased intracellular iron levels caused by heightened NCOA4‐mediated ferritinophagy, which fostered PHD2‐mediated HIF‐1α destabilization. These effects were not phenocopied by ATG5 or NIX silencing. Restoring HIF‐1α levels in BNIP3‐depleted melanoma cells rescued their metabolic phenotype and tumor growth in vivo, but did not affect NCOA4 turnover, underscoring that these BNIP3 effects are not secondary to HIF‐1α. These results unravel an unexpected role of BNIP3 as upstream regulator of the pro‐tumorigenic HIF‐1α glycolytic program in melanoma cells. 相似文献
74.
La Boyrie Corentin Moreau Florian Frugier Christophe Jacquet Maxime Bonhomme 《Heredity》2021,126(1):77
The quest for signatures of selection using single nucleotide polymorphism (SNP) data has proven efficient to uncover genes involved in conserved and/or adaptive molecular functions, but none of the statistical methods were designed to identify interacting alleles as targets of selective processes. Here, we propose a statistical test aimed at detecting epistatic selection, based on a linkage disequilibrium (LD) measure accounting for population structure and heterogeneous relatedness between individuals. SNP-based () and window-based () statistics fit a Student distribution, allowing to test the significance of correlation coefficients. As a proof of concept, we use SNP data from the Medicago truncatula symbiotic legume plant and uncover a previously unknown gene coadaptation between the MtSUNN (Super Numeric Nodule) receptor and the MtCLE02 (CLAVATA3-Like) signaling peptide. We also provide experimental evidence supporting a MtSUNN-dependent negative role of MtCLE02 in symbiotic root nodulation. Using human HGDP-CEPH SNP data, our new statistical test uncovers strong LD between SLC24A5 (skin pigmentation) and EDAR (hairs, teeth, sweat glands development) world-wide, which persists after correction for population structure and relatedness in Central South Asian populations. This result suggests that epistatic selection or coselection could have contributed to the phenotypic make-up in some human populations. Applying this approach to genome-wide SNP data will facilitate the identification of coadapted gene networks in model or non-model organisms.Subject terms: Population genetics, Epistasis, Rhizobial symbiosis 相似文献
75.
Legume plants form nitrogen (N)-fixing symbiotic nodules when mineral N is limiting in soils. As N fixation is energetically costly compared to mineral N acquisition, these N sources, and in particular nitrate, inhibit nodule formation and N fixation. Here, in the model legume Medicago truncatula, we characterized a CLAVATA3-like (CLE) signaling peptide, MtCLE35, the expression of which is upregulated locally by high-N environments and relies on the Nodule Inception-Like Protein (NLP) MtNLP1. MtCLE35 inhibits nodule formation by affecting rhizobial infections, depending on the Super Numeric Nodules (MtSUNN) receptor. In addition, high N or the ectopic expression of MtCLE35 represses the expression and accumulation of the miR2111 shoot-to-root systemic effector, thus inhibiting its positive effect on nodulation. Conversely, ectopic expression of miR2111 or downregulation of MtCLE35 by RNA interference increased miR2111 accumulation independently of the N environment, and thus partially bypasses the nodulation inhibitory action of nitrate. Overall, these results demonstrate that the MtNLP1-dependent, N-induced MtCLE35 signaling peptide acts through the MtSUNN receptor and the miR2111 systemic effector to inhibit nodulation.Expression of a Medicago truncatula signaling peptide is upregulated by nitrate and inhibits nodulation through repression of the accumulation of a microRNA. 相似文献
76.
Gaudichet Corentin Greulich Sabine Grellier Sraphine Rodrigues Stphane 《Hydrobiologia》2022,849(6):1383-1396
Hydrobiologia - This research aimed to disentangle the role of the connectivity gradient as a dispersal and environmental filter. This was done by comparing community composition and plant... 相似文献
77.
Olivier Pereira Corentin Hochart Dominique Boeuf Jean Christophe Auguet Didier Debroas Pierre E. Galand 《The ISME journal》2021,15(5):1302
The Archaea Marine Group II (MGII) is widespread in the world’s ocean where it plays an important role in the carbon cycle. Despite recent discoveries on the group’s metabolisms, the ecology of this newly proposed order (Candidatus Poseidoniales) remains poorly understood. Here we used a combination of time-series metagenome-assembled genomes (MAGs) and high-frequency 16S rRNA data from the NW Mediterranean Sea to test if the taxonomic diversity within the MGIIb family (Candidatus Thalassarchaeaceae) reflects the presence of different ecotypes. The MAGs’ seasonality revealed a MGIIb family composed of different subclades that have distinct lifestyles and physiologies. The vitamin metabolisms were notably different between ecotypes with, in some, a possible link to sunlight’s energy. Diverse archaeal proteorhodopsin variants, with unusual signature in key amino acid residues, had distinct seasonal patterns corresponding to changing day length. In addition, we show that in summer, archaea, as opposed to bacteria, disappeared completely from surface waters. Our results shed light on the diversity and the distribution of the euryarchaeotal proteorhodopsin, and highlight that MGIIb is a diverse ecological group. The work shows that time-series based studies of the taxonomy, seasonality, and metabolisms of marine prokaryotes is critical to uncover their diverse role in the ocean.Subject terms: Microbial ecology, Microbial communities 相似文献
78.
79.
Marion Picard Satoru Yonekura Karolina Slowicka Ioanna Petta Conrad Rauber Bertrand Routy Corentin Richard Valerio Iebba Maryam Tidjani Alou Sonia Becharef Pierre Ly Eugenie Pizzato Christian H. K. Lehmann Lukas Amon Christophe Klein Paule Opolon Ivo Gomperts Boneca Jean-Yves Scoazec Antoine Hollebecque David Malka Franois Ghiringhelli Diana Dudziak Geert Berx Lars Vereecke Geert van Loo Guido Kroemer Laurence Zitvogel Maria Paula Roberti 《Cell death and differentiation》2021,28(5):1532
80.
Body location and tail regeneration effects on osteoderms morphology—are they useful tools for systematic,paleontology, and skeletochronology in diploglossine lizards (squamata,anguidae)?
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Corentin Bochaton Vivian De Buffrenil Michel Lemoine Salvador Bailon Ivan Ineich 《Journal of morphology》2015,276(11):1333-1344