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621.
Rossana de Aguiar Cordeiro Ana Raquel Colares de Andrade Fernando Victor Monteiro Portela Lívia Maria Galdino Pereira Santiago Gonçalves Bezerra Moura Mônica Dantas Sampaio 《Biofouling》2020,36(5):610-620
AbstractThis study proposes a microcosm biofilm (MiB) model for the study of vulvovaginal candidiasis (VVC). Different conditions that mimic the vaginal environment were tested for MiB formation. The best growth conditions were obtained with samples incubated in vaginal fluid simulator medium pH 4.5 at 35?°C under a microaerophilic atmosphere. MiBs were evaluated for growth kinetics, fluconazole susceptibility and morphology. Samples containing high numbers of bacteria were analyzed for metagenomics. At 48?h, MiBs presented a higher cell density (CFU ml?1), a higher biomass and tolerance to fluconazole than their corresponding monospecies biofilms. Morphological analysis of MiBs revealed blastoconidia preferentially adhered to epithelial cells. Abundant Lactobacillus spp. were detected in two clinical samples; their MiBs showed a lower biomass and a higher fluconazole susceptibility. The proposed model proved to be a useful tool for the study of the complex microbial relationship in the vaginal environment, and may help to find new strategies for VVC control. 相似文献
622.
Larissa Luz Gomes Fabiano Cordeiro Moreira Igor Guerreiro Hamoy Sidney Santos Paulo Assump??o ádamo L. Santana ?ndrea Ribeiro-dos-Santos 《Bioinformation》2014,10(5):246-250
In this paper, an unsupervised artificial neural network was implemented to identify the patters of specific signatures. The network
was based on the differential expression of miRNAs (under or over expression) found in healthy or cancerous gastric tissues.
Among the tissues analyzes, the neural network evaluated 514 miRNAs of gastric tissue that exhibited significant differential
expression. The result suggested a specific expression signature nine miRNAs (hsa-mir-21, hsa-mir-29a, hsa-mir-29c, hsa-mir-148a,
hsa-mir-141, hsa-let-7b, hsa-mir-31, hsa-mir-451, and hsa-mir-192), all with significant values (p-value < 0.01 and fold change > 5) that
clustered the samples into two groups: healthy tissue and gastric cancer tissue. The results obtained “in silico” must be validated in
a molecular biology laboratory; if confirmed, this method may be used in the future as a risk marker for gastric cancer
development. 相似文献
623.