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51.
Advanced computer graphics technology reveals cortical asymmetry in endocasts of rhesus monkeys 总被引:1,自引:0,他引:1
D Falk J Cheverud M W Vannier G C Conroy 《Folia primatologica; international journal of primatology》1986,46(2):98-103
Lengths of cortical sulci were measured on ten endocranial casts (endocasts) from skulls of rhesus monkeys, using advanced computer technology that permits analysis and imaging of surface morphology in three dimensions. Sulcal lengths were compared in left and right hemispheres and, contrary to earlier reports, the length of the left Sylvian fissure was found to be significantly longer than its right counterpart, as is the case for chimpanzees and humans. This asymmetry in humans is thought to be associated with asymmetrical representation of language functions in the left hemisphere and, although this report is the first to demonstrate a significantly longer left Sylvian fissure in rhesus monkeys, our results are in keeping with psychophysical evidence that suggests that Macaca is left hemisphere dominant for perception of meaningful vocalizations. We attribute the difference between our findings and previous reports to the sensitivity of the new computer technology used to collect data from endocasts. 相似文献
52.
Joshua T. Vogelstein John M. Conroy Vince Lyzinski Louis J. Podrazik Steven G. Kratzer Eric T. Harley Donniell E. Fishkind R. Jacob Vogelstein Carey E. Priebe 《PloS one》2015,10(4)
Quadratic assignment problems arise in a wide variety of domains, spanning operations research, graph theory, computer vision, and neuroscience, to name a few. The graph matching problem is a special case of the quadratic assignment problem, and graph matching is increasingly important as graph-valued data is becoming more prominent. With the aim of efficiently and accurately matching the large graphs common in big data, we present our graph matching algorithm, the Fast Approximate Quadratic assignment algorithm. We empirically demonstrate that our algorithm is faster and achieves a lower objective value on over 80% of the QAPLIB benchmark library, compared with the previous state-of-the-art. Applying our algorithm to our motivating example, matching C. elegans connectomes (brain-graphs), we find that it efficiently achieves performance. 相似文献
53.
Fragile X syndrome and other trinucleotide diseases are characterized by an elongation of a repeating DNA triplet. The ensemble-averaged
lambda exonuclease digestion rate of different substrates, including one with an elongated FMR1 gene containing 120 CGG repeats,
was measured using absorption and fluorescence spectroscopy. By use of magnetic tweezers sequence-dependent digestion rates
and pausing was measured for individual lambda exonucleases. Within the triplet repeats a lower average and narrower distribution
of rates and a higher frequency of pausing was observed. 相似文献
54.
55.
The introduction and use of ornamental plants in gardens is the main pathway for plant invasions globally. High numbers of ornamental plants in gardens may not have started an invasion process yet and are a risk for possible future invasions. Gardeners could be among the first to notice plant traits that have also been recognised to contribute to the potential risk of ornamental plants to escape from cultivation. We asked gardeners in Britain to report ornamental plants that were spreading within their gardens and difficult to control using an online survey. Gardeners submitted 201 records of 121 species of which 104 are non-native in Britain. Most non-native species reported were already recorded and wide-spread in Britain outside cultivation, but about a third are not widely distributed, and eight species are not known outside cultivation. Gardeners’ control efforts were mainly directed to confine plants from further spread, but they also tried to eradicate many of the reported plants. Our results provide evidence that gardeners’ knowledge could help to identify potentially problematic invasive plants early in the invasion process. Even with low levels of participation all evidence collected would be very valuable in official risk management procedures as well as supporting legal obligations on early detection, surveillance and monitoring. At the same time, however, raising awareness of the problem by actively collaborating with gardeners could be of equal importance for the prevention of ornamental plant invasions in the future. 相似文献
56.
Tanner J. Williamson Michael J. Vanni María J. González William H. Renwick Mary T. Bremigan Joseph D. Conroy 《Biogeochemistry》2018,140(2):233-253
Animals transform and translocate nutrients at ecologically relevant rates, contributing to eutrophication in aquatic ecosystems by mobilizing otherwise unavailable nutrients. Yet we know little about how animal-mediated nutrient cycling compares with external abiotic nutrient sources over long periods (years–decades) and at multiple timescales. To address this, we conducted a 19-year study in a eutrophic reservoir examining nitrogen (N) and phosphorus (P) inputs from watershed streams versus excretion by an abundant fish (gizzard shad, Dorosoma cepedianum) at weekly, monthly and seasonal timescales. Over the entire time period, watershed N and P loading was 33- and 3-fold greater than fish N and P excretion, respectively. However, fish N excretion exceeded watershed nutrient loading in 36% of weeks and 43% of months, and fish P excretion in 68% of weeks and 58% of months during the growing season. Fish excretion had lower temporal variability in both supply rate and N:P ratio than watershed loading. Fish excretion also supplied nutrients at a much lower molar N:P ratio than the watershed (mean of daily N:P supply ratios were 15 and 723, respectively). In eutrophic lakes with high fish biomass, fish excretion can strongly influence algal biomass and community composition. Eutrophication management efforts should consider removal of benthivorous fish, like gizzard shad, in addition to other watershed management practices to improve water quality. Future climate change will modulate the interplay between fish- and watershed-mediated nutrient dynamics by altering the geographic distribution of detritivorous fish and the frequency and severity of storm and drought events. 相似文献
57.
Accelerated Early Growth of Rice at Elevated CO2 (Is It Related to Developmental Changes in the Shoot Apex?)
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The influence of elevated CO2 on the development of the shoot apex and on subsequent vegetative growth and grain yield was investigated using rice (Oryza sativa L. cv Jarrah) grown in flooded soil at either 350 or 700 [mu]L CO2 L-1. At 8 d after planting (DAP), elevated CO2 increased the height and diameter of the apical dome and lengths of leaf primordia and tiller buds but had no effect on their numbers. By 16 DAP, there were five tiller buds in the apex at 700 [mu]L CO2 L-1 compared with only three tiller buds at 350 [mu]L CO2 L-1. These changes in development of the shoot apex at high CO2 were forerunners to faster development of the vegetative shoot at elevated CO2 between 11 and 26 DAP as evidenced by increases in the relative growth rates of the shoot and tillers. Accelerated development at high CO2 was responsible for the 42% increase in tiller number at the maximum tillering stage and the 57% enhancement of grain yield at the final harvest. The link between high CO2 effects on development during the first 15 DAP and final tiller number and grain yield was demonstrated by delaying exposure of plants to high CO2 for 15 d. The delay totally inhibited the tillering response to high CO2, and the increase in grain yield of 20% arose from a greater number of grains per panicle. Consequently, it can be concluded that accelerated development in the shoot apex early in development is crucial for obtaining maximum increases in grain yield at elevated atmospheric CO2 concentrations. 相似文献
58.
59.
Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells 总被引:1,自引:0,他引:1
Sphingosine kinase 1 (SphK1) is a lipid kinase implicated in mitogenic signaling pathways in vascular smooth muscle cells. We demonstrate that human coronary artery smooth muscle (HCASM) cells require SphK1 for growth and that SphK1 mRNA and protein levels are elevated in PDGF stimulated HCASM cells. To determine the mechanism of PDGF-induced SphK1 expression, we used pharmacological inhibitors of the PI3K/AKT/mTOR signaling pathway. Wortmannin, SH-5, and rapamycin significantly blocked PDGF-stimulated induction of SphK1 mRNA and protein expression, indicating a regulatory role of the PI3K/AKT/mTOR pathway in SphK1 expression. To determine which isoform of AKT regulates SphK1 mRNA and protein levels, siRNAs specific for AKT1, AKT2, and AKT3 were used. We show that AKT2 siRNA significantly blocked PDGF-stimulated increases in SphK1 mRNA and protein expression levels as well as SphK1 enzymatic activity levels. In contrast, AKT1 or AKT3 siRNA did not have an effect. Together, these results demonstrate that the PI3K/AKT/mTOR signaling pathway is involved in regulation of SphK1, with AKT2 playing a key role in PDGF-induced SphK1 expression in HCASM cells. 相似文献
60.
Isolation and Characterization of a Hantavirus from Lemmus sibiricus: Evidence for Host Switch during Hantavirus Evolution 总被引:9,自引:0,他引:9
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Olli Vapalahti ke Lundkvist Vadim Fedorov Christopher J. Conroy Sirpa Hirvonen Angelina Plyusnina Kirill Nemirov Karl Fredga Joseph A. Cook Jukka Niemimaa Asko Kaikusalo Heikki Henttonen Antti Vaheri Alexander Plyusnin 《Journal of virology》1999,73(7):5586-5592
A novel hantavirus, first detected in Siberian lemmings (Lemmus sibiricus) collected near the Topografov River in the Taymyr Peninsula, Siberia (A. Plyusnin et al., Lancet 347:1835-1836, 1996), was isolated in Vero E6 cells and in laboratory-bred Norwegian lemmings (Lemmus lemmus). The virus, named Topografov virus (TOP), was most closely related to Khabarovsk virus (KBR) and Puumala viruses (PUU). In a cross focus reduction neutralization test, anti-TOP Lemmus antisera showed titers at least fourfold higher with TOP than with other hantaviruses; however, a rabbit anti-KBR antiserum neutralized TOP and KBR at the same titer. The TOP M segment showed 77% nucleotide and 88% amino acid identity with KBR and 76% nucleotide and 82% amino acid identity with PUU. However, the homology between TOP and the KBR S segment was disproportionately higher: 88% at the nucleotide level and 96% at the amino acid level. The 3' noncoding regions of KBR and the TOP S and M segments were alignable except for 113- and 58-nucleotide deletions in KBR. The phylogenetic relationships of TOP, KBR, and PUU and their respective rodent carriers suggest that an exceptional host switch took place during the evolution of these viruses; while TOP and KBR are monophyletic, the respective rodent host species are only distantly related. 相似文献