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141.
LncRNA LINC00880 promotes cell proliferation,migration, and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma
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142.
Methylation‐associated DOK1 and DOK2 down‐regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia
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143.
Bafilomycin A1 Attenuates Osteoclast Acidification and Formation,Accompanied by Increased Levels of SQSTM1/p62 Protein
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144.
Zi Peng Xiaoya Yuan Yingbo Huang Jin Mo Jianxi Tan Huiping Zhou Libing Wang 《Molecular breeding : new strategies in plant improvement》2016,36(2):19
Recent DNA sequencing projects and the establishment of high-throughput assays have provided an abundance of sequence information and data on nucleotide polymorphisms in rice. Based on previously identified single-nucleotide polymorphisms (SNPs) and insertions/deletions, we employed denaturing high-performance liquid chromatography (DHPLC) to genotype rice varieties using a chromatographic pattern-based strategy. In this study, 12 amplicons harboring multiple and informative SNPs were screened. PCR products of the 12 amplicons from 47 rice varieties were analyzed by DHPLC and DNA sequencing. Each homozygous sample with a single peak pattern in the initial DHPLC analysis was mixed with zhenshan97 for a second DHPLC analysis. The 12 amplicons were found to be polymorphic across the hybrids, and mixed homozygous samples with 43 distinct DHPLC elution profiles detected. Sequence analysis confirmed that the distinct DHPLC patterns corresponded to different DNA sequences. A set of distinct characteristic profiles in six amplicons differentiated between all of the hybrids, inbred lines, and restorer lines and produced unique a fingerprint for these lines. In addition, we found that the DHPLC pattern of the hybrid was in accordance with the results obtained by DHPLC analysis of a mixed sample of the two parents. These results demonstrate that DHPLC can be efficiently applied for the rapid and automated identification of diverse rice varieties and could possibly be utilized for seed genetic purity testing on a high-throughput scale. 相似文献
145.
Wei Jing Liu Lin Ye Wei Fang Huang Lin Jie Guo Zi Gan Xu Hong Luan Wu Chen Yang Hua Feng Liu 《Cellular & molecular biology letters》2016,21(1):29
The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical roles in cell survival under normal conditions and during stress. An increasing body of evidence indicates that ubiquitinated cargoes are important markers of degradation. p62, a classical receptor of autophagy, is a multifunctional protein located throughout the cell and involved in many signal transduction pathways, including the Keap1–Nrf2 pathway. It is involved in the proteasomal degradation of ubiquitinated proteins. When the cellular p62 level is manipulated, the quantity and location pattern of ubiquitinated proteins change with a considerable impact on cell survival. Altered p62 levels can even lead to some diseases. The proteotoxic stress imposed by proteasome inhibition can activate autophagy through p62 phosphorylation. A deficiency in autophagy may compromise the ubiquitin–proteasome system, since overabundant p62 delays delivery of the proteasomal substrate to the proteasome despite proteasomal catalytic activity being unchanged. In addition, p62 and the proteasome can modulate the activity of HDAC6 deacetylase, thus influencing the autophagic degradation. 相似文献
146.
玫瑰花红色素及其稳定性研究 总被引:28,自引:0,他引:28
以玫瑰花色素作为新型天然食用色素的可行性进行了初步研究。对光、温度、pH值、氧化介质、还原介质、蔗糖、咸味(NaCl)、铝制品(FeCl3)、铜制品(CuCl2)、锡制品(SnCl2)等对色素的稳定性影响,进行了初步探讨。结果表明,该色素对光、热耐受性好;适用pH值范围宽;耐氧化性较差,耐还原性较好;Fe^3+和Sn^2+对其吸光值有明显影响,Cu^2+、Al^3+、食盐和蔗糖则影响甚微。 相似文献
147.
影响陕西种源香椿硬枝插条培养生产芽菜因素的研究 总被引:1,自引:0,他引:1
试验结果表明,陕西种源香椿硬枝插条在温室进行芽菜培育休眠芽萌发的最低温度指标为16.8℃,有效积温39.6℃。培养液;(NH4)2SO40.6g/L (NH4)H2PO40.45g/L KH2PO41.1g/L CaSO40.6g/L MgSO40.5g/L,其效果较其它溶液为好。 相似文献
148.
在云南省西南边境9县市捕获伊蚊属雌性成蚊16种19367只,用细胞法和乳鼠法分离病毒。从185批6491只白纹伊蚊中分离到病毒2株,从50批1605只剌扰伊蚊中分离到病毒2株,从23批772只窄翅伊蚊中分离到病毒2株,从4批103只阿萨姆伊蚊中分离到病毒1株。其它12种共10396只伊蚊的病毒分离物为阴性。分离到的7株病毒经免疫荧光、酶免疫、血凝抑制和中和试验鉴定,均为乙型脑炎病毒(JEvirus)。白纹伊蚊是野外竹林的优势蚊种。分析认为白纹伊蚊在当地乙型脑炎病毒保存和传播中起重要作用,刺扰伊蚊、窄翅伊蚊和阿萨姆伊蚊亦可参与该病毒的传播。 相似文献
149.
Chao Wang Yuelin Li Zi Liu Zeyu Wang Zihan Liu Shuai Man Yujing Zhang Kai Bao Yingliang Wu Qi Guan Daiying Zuo Weige Zhang 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):549
A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key intermediates ethyl 1-aryl-1H-tetrazole-5-carboxylates 10 can be simply and efficiently prepared via a microwave-assisted continuous operation process. Among the compounds synthesised, compound 6–31 showed noteworthy potency against SGC-7901, A549 and HeLa cell lines. In mechanism studies, compound 6–31 inhibited tubulin polymerisation and disorganised microtubule in SGC-7901 cells by binding to tubulin. Moreover, compound 6–31 arrested SGC-7901cells in G2/M phase. This study provided a new perspective for development of antitumor agents that target tubulin. 相似文献
150.
MG132 Induces Expression of Monocyte Chemotactic Protein‐Induced Protein 1 in Vascular Smooth Muscle Cells
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