Assembly of splicing complexes on exon 11 of the human insulin receptor gene does not correlate with splicing efficiency in-vitro

Background  

Incorporation of exon 11 of the insulin receptor gene is both developmentally and hormonally-regulated. Previously, we have shown the presence of enhancer and silencer elements that modulate the incorporation of the small 36-nucleotide exon. In this study, we investigated the role of inherent splice site strength in the alternative splicing decision and whether recognition of the splice sites is the major determinant of exon incorporation.     

Human presence drives bobcat interactions among the U.S. carnivore guild

Biodiversity and Conservation - Mammalian carnivores are elusive and enigmatic species that often play keystone roles in ecosystems through direct and indirect effects. Growing evidence shows that...