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151.
Christina D. Cota Matthew S. Dreier William Colgan Anna Cha Twan Sia Brad Davidson 《PLoS biology》2021,19(1)
Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic kinases in receptor trafficking during asymmetric division. Targeted perturbations reveal that Cyclin-dependent Kinase 1 (CDK1) and Aurora Kinase promote storage of Fibroblast Growth Factor Receptors (FGFRs) by suppressing endosomal degradation and recycling pathways. As cells progress through metaphase, loss of CDK1 activity permits differential degradation and targeted recycling of stored receptors, leading to asymmetric induction. Mitotic receptor storage, as delineated in this study, may facilitate rapid reestablishment of signaling competence in nascent daughter cells. However, mutations that limit or enhance the release of stored signaling components could alter daughter cell fate or behavior thereby promoting oncogenesis.This study provides fundamental insights into the crosstalk between cell division and signaling, with implications for cancer. High-resolution in vivo analysis reveals that dividing cells sequester signal receptor proteins into internal compartments; stored receptors are then redistributed as cells complete division. 相似文献
152.
D. J. Colgan 《Genetica》1985,67(2):81-85
This paper reports an example of an abundant soluble protein which differs in electrophoretic phenotype between embryos and
adults of the grasshopper,Caledia captiva. It is argued that the change in phenotype is evolutionarily significant for three reasons. First, it is taxonomically widespread.
Secondly, the low level of intrapopulational polymorphism implies that it is subject to strict selective constraints. Thirdly,
the change occurs in spite of the presumably high metabolic cost engendered by the rapidity of its accomplishment at hatching. 相似文献
153.
Anders Hallan Donald J. Colgan Laurie C. Anderson Adriana García Allan R. Chivas 《Zoologica scripta》2013,42(3):278-287
The bivalve family Corbulidae, known colloquially as ‘basket clams’, includes species tolerating a wide variety of habitats ranging from open marine to freshwater. Previous studies of corbulid phylogenetics have been based mainly on shell morphology and to some extent soft tissue anatomy. However, these studies have been inadequate for corbulid classification because of difficulties in determining the inter‐relationships of primarily marine species with non‐marine species, the latter commonly exhibiting highly divergent morphological, ecological and environmental characteristics from their marine counterparts. The first molecular phylogenetic study of the Corbulidae is presented herein, analysing DNA sequences from the 18S rRNA and 28S rRNA genes, separately and in combination. Fifteen corbulid species and 14 outgroup taxa were included in the analyses. Corbulidae is resolved as monophyletic, comprising three groups with varying support. The non‐marine species form one group that we name as the subclade ‘limnetic–euryhaline Corbulidae’ (LEC) and comprising the genera Lentidium, Erodona and Potamocorbula. This LEC, which is consistently recovered as monophyletic, is globally distributed. The marine Corbulidae are divided into two well‐supported lineages in combined analyses although there are inconsistencies in their membership between single‐gene analyses. One of the two lineages consists of primarily Western Pacific taxa and the other of North American and Caribbean taxa. Finally, the authors advocate further study on the LEC to mitigate potential biological invasions beyond their native distribution. 相似文献
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