全文获取类型
收费全文 | 605篇 |
免费 | 67篇 |
国内免费 | 32篇 |
出版年
2022年 | 6篇 |
2021年 | 10篇 |
2020年 | 9篇 |
2019年 | 7篇 |
2018年 | 13篇 |
2017年 | 10篇 |
2016年 | 14篇 |
2015年 | 15篇 |
2014年 | 21篇 |
2013年 | 33篇 |
2012年 | 46篇 |
2011年 | 45篇 |
2010年 | 24篇 |
2009年 | 22篇 |
2008年 | 37篇 |
2007年 | 18篇 |
2006年 | 36篇 |
2005年 | 16篇 |
2004年 | 16篇 |
2003年 | 20篇 |
2002年 | 11篇 |
2001年 | 12篇 |
2000年 | 8篇 |
1999年 | 9篇 |
1998年 | 15篇 |
1997年 | 12篇 |
1996年 | 6篇 |
1995年 | 9篇 |
1994年 | 7篇 |
1993年 | 7篇 |
1992年 | 12篇 |
1990年 | 9篇 |
1989年 | 6篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1984年 | 4篇 |
1983年 | 7篇 |
1981年 | 11篇 |
1980年 | 6篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1977年 | 9篇 |
1976年 | 5篇 |
1975年 | 8篇 |
1974年 | 8篇 |
1973年 | 4篇 |
1972年 | 7篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1949年 | 5篇 |
排序方式: 共有704条查询结果,搜索用时 15 毫秒
81.
82.
83.
DA Rosa AC Lessinger AC DE Azeredo-Espin AM Torres TT 《Molecular ecology resources》2008,8(5):971-973
The horn fly, Haematobia irritans (L.) (Diptera: Muscidae), is a cosmopolitan livestock pest that has caused a great negative impact on the animal production sector throughout the world. Here, we describe 10 polymorphic microsatellite loci isolated from H. irritans. The number of alleles found ranged from two to eight per locus and the expected heterozygosity from 0.1421 to 0.7702. These loci are potentially useful for the fine-scale genetic characterization of horn fly populations and provide fundamental information for pest management and planning of control programs. 相似文献
84.
Our study focused on colony dynamics of the red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae), in relation to the standard practice of planting rye grass (i.e., plowing) in the fall in Louisiana. Microsatellite molecular markers were used to determine genotypes of individuals from red imported fire ant colonies. These markers allowed us to monitor treatment effect by detecting changes in number and location of colonies in response to disking of pasture plots. Previous research on mound disturbance as a form of cultural control in pastures has produced mixed results. We found that the majority of colonies persisted on plots after plowing. Mound density and mound area, 5 mo after plowing, were not significantly different among treatments. In contrast, April measurements of mound volume were significantly smaller on plowed plots compared with control plots. A closer look at the rebuilding of mounds on plowed plots, during the 5 mo, showed that mound heights stayed below pretreatment measurements and they were significantly smaller than those of undisturbed mounds. Whether plowing has potential for use as a cultural control technique in reducing the impact of red imported fire ant mounds on agricultural practices in pastures remains to be seen. Conceivably, the best application of this technique will be in combination with other control measures in an integrated pest management approach to control red imported fire ants in pastures. 相似文献
85.
GUO XING ZHONG JUN DA SU QING WEN SUN BING HUA JIAO Department of Biochemistry Molecular Biology Second Military Medical University Shanghai School of Life Sciences Medical Engineering Tongji University Shanghai China Shangha 《Cell research》2001,(4)
INTRODUCTIONEstrogen has been known to exert extensive effects via estrogen receptor (ER) on diverse physio-logical and develoPmental functions of the brain[1,2]. It has been observed that the distribution ofthe classical ER subtype-a (ERa) and the recentlycharacterized novel ER subtype--fi (ERg), and theirexpression patterns (ERcr/ERfi) vary greatly amongvarious brain regions[1, 3]. These evidences suggestthat each ER subtype may play a different role inestrogen's effects on the br… 相似文献
86.
87.
88.
89.
90.
Naveen Parmar Kyle Burrows Pia M. Vornewald Hvard T. Lindholm Rosalie T. Zwiggelaar Alberto Díez-Snchez Mara Martín-Alonso Madeleine Fosslie Bruce A. Vallance John Arne Dahl Colby Zaph Menno J. Oudhoff 《PLoS pathogens》2021,17(3)
Infectious and inflammatory diseases in the intestine remain a serious threat for patients world-wide. Reprogramming of the intestinal epithelium towards a protective effector state is important to manage inflammation and immunity and can be therapeutically targeted. The role of epigenetic regulatory enzymes within these processes is not yet defined. Here, we use a mouse model that has an intestinal-epithelial specific deletion of the histone demethylase Lsd1 (cKO mice), which maintains the epithelium in a fixed reparative state. Challenge of cKO mice with bacteria-induced colitis or a helminth infection model both resulted in increased pathogenesis. Mechanistically, we discovered that LSD1 is important for goblet cell maturation and goblet-cell effector molecules such as RELMß. We propose that this may be in part mediated by directly controlling genes that facilitate cytoskeletal organization, which is important in goblet cell biology. This study therefore identifies intestinal-epithelial epigenetic regulation by LSD1 as a critical element in host protection from infection. 相似文献