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311.
Public concern over the environmental and public health impacts of the emerging contaminant class “microplastics” has recently prompted government agencies to consider mitigation efforts. Microplastics do not easily fit within traditional risk-based regulatory frameworks because their persistence and extreme diversity (of size, shape, and chemical properties associated with sorbed chemicals) result in high levels of uncertainty in hazard and exposure estimates. Due to these serious complexities, addressing microplastics’ impacts requires open collaboration between scientists, regulators, and policymakers. Here we describe ongoing international mitigation efforts, with California as a case study, and draw lessons from a similarly diverse and environmentally persistent class of emerging contaminants (per- and polyfluoroalkyl substances) that is already disrupting traditional regulatory paradigms, discuss strategies to address challenges associated with developing health-protective regulations and policies related to microplastics, and suggest ways to maximize impacts of research.Mounting concerns regarding the deleterious effects of plastic pollution have prompted recent government mitigation efforts, but microplastics challenge traditional risk-based regulatory frameworks due to their particle properties, diverse composition and persistence. Using California as a case study, the Essay suggests strategies to address challenges with regulations, policies and research, drawing parallels with a similar class of emerging contaminants (per- and polyfluoroalkyl substances). 相似文献
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Search for the Mechanism of Genetic Variation in the pro Gene of Human Immunodeficiency Virus 总被引:5,自引:0,他引:5
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To study the mechanism of evolution of the human immunodeficiency virus (HIV) protease gene (pro), we analyzed a database of 213 pro sequences isolated from 11 HIV type 1-infected patients who had not been treated with protease inhibitors. Variation in pro is restricted to rare variable bases which are highly diverse and differ in location among individuals; an average variable base appears in about 16% of individuals. The average intrapatient distance per individual variable site, 27%, is similar for synonymous and nonsynonymous sites, although synonymous sites are twice as abundant. The latter observation excludes selection for diversity as an important, permanently acting factor in the evolution of pro and leaves purifying selection as the only kind of selection. Based on this, we developed a model of evolution, both within individuals and along the transmission chain, which explains variable sites as slightly deleterious mutants slowly reverting to the better-fit variant during individual infection. In the case of a single-source transmission, genetic bottlenecks at the moment of transmission effectively suppress selection, allowing mutants to accumulate along the transmission chain to high levels. However, even very rare coinfections from independent sources are, as we show, able to counteract the bottleneck effect. Therefore, there are two possible explanations for the high mutant frequency. First, the frequency of coinfection in the natural host population may be quite low. Alternatively, a strong variation of the best-adapted sequence between individuals could be caused by a combination of an immune response present in early infection and coselection. 相似文献
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Roloson Scott D. Coffin Michael R. S. Knysh Kyle M. van den Heuvel Michael R. 《Hydrobiologia》2021,848(17):4001-4016
Hydrobiologia - Many present-day aquatic ecosystems are defined by anthropogenic activities such as the introduction of non-native species, habitat loss, and eutrophication. On Prince Edward... 相似文献
316.
Determination of 3' end processing in retroelements 总被引:3,自引:0,他引:3