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排序方式: 共有592条查询结果,搜索用时 15 毫秒
571.
572.
Marques Daniel Ruivo Gomes Ana Allen Clemente Vanda dos Santos José Moutinho Serra Joana de Azevedo Maria Helena Pinto 《Sleep and biological rhythms》2020,18(3):199-207
Sleep and Biological Rhythms - Insomnia disorder has known striking developments over the last few years. Partly due to advances in neuroimaging techniques and brain sciences, our understanding of... 相似文献
573.
N di Clemente S Ghaffari R B Pepinsky C Pieau N Josso R L Cate B Vigier 《Development (Cambridge, England)》1992,114(3):721-727
Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance or factor, has previously been shown to sex-reverse the steroidogenic pattern of fetal mammalian ovaries through repression of aromatase biosynthesis. Study of the ontogeny of the response of cyclic AMP-stimulated aromatase activity of rat fetal ovaries to AMH has allowed us to develop a quantitative bioassay for the hormone. Linear responses as a function of the logarithm of AMH concentration were observed over ranges of 0.2-7.5 micrograms/ml for the bovine protein and 0.15-2 micrograms/ml for the human protein, with a maximal decrease in aromatase activity of 90% for both proteins. Under the same in vitro conditions, AMH treatment did not affect cyclic AMP-stimulated fetal rat testicular aromatase activity. Partially purified chick AMH also decreased rat ovarian aromatase activity, allowing us to use this test to study AMH ontogeny in chick gonads. Analysis of the species specificity of AMH repression of ovarian aromatase activity indicated that turtle and rat fetal ovaries responded to AMH of other vertebrate classes, whereas aromatase activity of chick embryo ovaries could be repressed only by the homospecific hormone. 相似文献
574.
575.
Atilla Akdemir Özlen Güzel-Akdemir Andrea Scozzafava Clemente Capasso Claudiu T. Supuran 《Bioorganic & medicinal chemistry》2013,21(17):5228-5232
Here, we investigate 28 structurally new sulfonamides and their subsequent testing for enzyme inhibition of cytosolic and tumor-associated carbonic anhydrases (CAs, EC 4.2.1.1). The compounds showed very potent inhibition of four physiologically relevant human (h) CA isoforms, namely hCA I, II, IX and XII. Interestingly, the KI values were in the nanomolar range for the tumor-associated hCA IX and hCA XII. Docking studies have revealed details regarding the very favorable interactions between the scaffolds of this new class of inhibitors and the active sites of the investigated CA isoforms. As there are reported cases of tumors overexpressing both CA II and IX, such potent inhibitors for the two isoforms as those detected in this work, may have applications for targeting more than one CA present in tumors. 相似文献
576.
S. Clemente A. Rodríguez A. Brito A. Ramos ó. Monterroso J. C. Hernández 《Coral reefs (Online)》2011,30(1):237-240
The occurrence of a hydrocoral of the genus Millepora has been recorded for the first time in the eastern subtropical Atlantic (Tenerife, Canary Islands), at a latitude of 11o
N of its previously known northernmost limit of distribution in the Cape Verde Islands. The moderate development of the colonies,
their fast growth rate and very restricted location indicate a recent colonization process, possibly related to an extreme
climatic event that took place in the summer of 2004, adding to the rising seawater temperatures in the region during recent
years. 相似文献
577.
M Liberatore M Nuti G Cascialli V Turchi M Clemente G Rossetto A Centi Colella A Pala 《The International journal of biological markers》1992,7(4):211-216
The purification of the IgM monoclonal antibody 436 against a breast tumor antigen from mouse ascitic fluid is reported. The purified immunoglobulin was radioiodinated and the resulting product assessed for its binding capacity and binding specificity. Purified IgM-436 served for F(ab')2 mu preparation which was tested for its antigen binding capacity. Radioiodinated IgM-436 and its F(ab')2 mu retained their immunological activity which was never lower than those of the corresponding cold products. 相似文献
578.
Claudia Melis Andrea Angeli Simona Distinto Giulia Bianco Clemente Capasso 《Journal of enzyme inhibition and medicinal chemistry》2017,32(1):68-73
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been studied and proposed as CAIs. In this study we have designed, synthesised, and evaluated the biological activity of a series of differently substituted isatin-based benzene sulphonamides which have been designed for the inhibition of carbonic anhydrase isoforms. The activity of all the synthesised compounds was evaluated towards human carbonic anhydrase I, II, IX, and XII isozymes. Our results indicate that the nature and position of substituents on the isatin ring can modulate both activity and isozyme selectivity. 相似文献
579.
Dialectical Anthropology - Based on long-term ethnographic research, including documentary research, qualitative interviews and observations made at a Portuguese shelter for “sex trafficked... 相似文献
580.