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741.
Atilla Akdemir Özlen Güzel-Akdemir Andrea Scozzafava Clemente Capasso Claudiu T. Supuran 《Bioorganic & medicinal chemistry》2013,21(17):5228-5232
Here, we investigate 28 structurally new sulfonamides and their subsequent testing for enzyme inhibition of cytosolic and tumor-associated carbonic anhydrases (CAs, EC 4.2.1.1). The compounds showed very potent inhibition of four physiologically relevant human (h) CA isoforms, namely hCA I, II, IX and XII. Interestingly, the KI values were in the nanomolar range for the tumor-associated hCA IX and hCA XII. Docking studies have revealed details regarding the very favorable interactions between the scaffolds of this new class of inhibitors and the active sites of the investigated CA isoforms. As there are reported cases of tumors overexpressing both CA II and IX, such potent inhibitors for the two isoforms as those detected in this work, may have applications for targeting more than one CA present in tumors. 相似文献
742.
S. Clemente A. Rodríguez A. Brito A. Ramos ó. Monterroso J. C. Hernández 《Coral reefs (Online)》2011,30(1):237-240
The occurrence of a hydrocoral of the genus Millepora has been recorded for the first time in the eastern subtropical Atlantic (Tenerife, Canary Islands), at a latitude of 11o
N of its previously known northernmost limit of distribution in the Cape Verde Islands. The moderate development of the colonies,
their fast growth rate and very restricted location indicate a recent colonization process, possibly related to an extreme
climatic event that took place in the summer of 2004, adding to the rising seawater temperatures in the region during recent
years. 相似文献
743.
M Liberatore M Nuti G Cascialli V Turchi M Clemente G Rossetto A Centi Colella A Pala 《The International journal of biological markers》1992,7(4):211-216
The purification of the IgM monoclonal antibody 436 against a breast tumor antigen from mouse ascitic fluid is reported. The purified immunoglobulin was radioiodinated and the resulting product assessed for its binding capacity and binding specificity. Purified IgM-436 served for F(ab')2 mu preparation which was tested for its antigen binding capacity. Radioiodinated IgM-436 and its F(ab')2 mu retained their immunological activity which was never lower than those of the corresponding cold products. 相似文献
744.
Claudia Melis Andrea Angeli Simona Distinto Giulia Bianco Clemente Capasso 《Journal of enzyme inhibition and medicinal chemistry》2017,32(1):68-73
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been studied and proposed as CAIs. In this study we have designed, synthesised, and evaluated the biological activity of a series of differently substituted isatin-based benzene sulphonamides which have been designed for the inhibition of carbonic anhydrase isoforms. The activity of all the synthesised compounds was evaluated towards human carbonic anhydrase I, II, IX, and XII isozymes. Our results indicate that the nature and position of substituents on the isatin ring can modulate both activity and isozyme selectivity. 相似文献
745.
Dialectical Anthropology - Based on long-term ethnographic research, including documentary research, qualitative interviews and observations made at a Portuguese shelter for “sex trafficked... 相似文献
746.
747.
de Oliveira Carolina Alcantara Mansano Vidal de Freitas Teixeira Simone Pádua Brandes Arno Fritz das Neves Baratto Leopoldo Clemente Leitão Suzana Guimarães Santana Michele Nunes Rodrigues Igor Almeida Paulino Juliana Villela 《Journal of plant research》2021,134(1):127-139
Journal of Plant Research - The Swartzia species are commonly known as bloodwood due to the red exudate released from the stem after injury. This exudate has aroused great... 相似文献
748.
749.
750.
Alexey G. Kikhney Clemente R. Borges Dmitry S. Molodenskiy Cy M. Jeffries Dmitri I. Svergun 《Protein science : a publication of the Protein Society》2020,29(1):66-75
Small‐angle scattering (SAS) of X‐rays and neutrons is a fundamental tool to study the nanostructural properties, and in particular, biological macromolecules in solution. In structural biology, SAS recently transformed from a specialization into a general technique leading to a dramatic increase in the number of publications reporting structural models. The growing amount of data recorded and published has led to an urgent need for a global SAS repository that includes both primary data and models. In response to this, a small‐angle scattering biological data bank (SASBDB) was designed in 2014 and is available for public access at www.sasbdb.org . SASBDB is a comprehensive, free and searchable repository of SAS experimental data and models deposited together with the relevant experimental conditions, sample details and instrument characteristics. SASBDB is rapidly growing, and presently has over 1,000 entries containing more than 1,600 models. We describe here the overall organization and procedures of SASBDB paying most attention to user‐relevant information during submission. Perspectives of further developments, in particular, with OneDep system of the Protein Data Bank, and also widening of SASBDB including new types of data/models are discussed. 相似文献