全文获取类型
收费全文 | 4544篇 |
免费 | 339篇 |
专业分类
4883篇 |
出版年
2021年 | 31篇 |
2020年 | 19篇 |
2019年 | 32篇 |
2018年 | 41篇 |
2017年 | 43篇 |
2016年 | 75篇 |
2015年 | 110篇 |
2014年 | 128篇 |
2013年 | 195篇 |
2012年 | 238篇 |
2011年 | 231篇 |
2010年 | 154篇 |
2009年 | 161篇 |
2008年 | 243篇 |
2007年 | 235篇 |
2006年 | 246篇 |
2005年 | 241篇 |
2004年 | 229篇 |
2003年 | 288篇 |
2002年 | 300篇 |
2001年 | 77篇 |
2000年 | 39篇 |
1999年 | 83篇 |
1998年 | 95篇 |
1997年 | 82篇 |
1996年 | 73篇 |
1995年 | 60篇 |
1994年 | 57篇 |
1993年 | 62篇 |
1992年 | 78篇 |
1991年 | 52篇 |
1990年 | 33篇 |
1989年 | 45篇 |
1988年 | 48篇 |
1987年 | 33篇 |
1986年 | 27篇 |
1985年 | 41篇 |
1984年 | 42篇 |
1983年 | 35篇 |
1982年 | 56篇 |
1981年 | 53篇 |
1980年 | 47篇 |
1979年 | 42篇 |
1978年 | 40篇 |
1977年 | 36篇 |
1976年 | 41篇 |
1975年 | 23篇 |
1974年 | 19篇 |
1973年 | 19篇 |
1971年 | 18篇 |
排序方式: 共有4883条查询结果,搜索用时 0 毫秒
81.
Abstract: Mouse brain tubulin was analyzed on isoelectric focusing gels. High-resolution gels utilizing Bio-Rad ampholytes (pH 4-6) revealed 5-6 bands in the region corresponding to the α-subunit of tubulin and 10 or more for the β-subunit. The same general banding pattern was observed regardless of the method of preparation of the tubulin. Two species prominent in the brains of immature mice, α6 and β2, virtually disappeared during maturation, while species β6 to β10 appeared. No significant changes from the mature pattern were seen during aging (examined at 12, 23, and 30 months of age). 相似文献
82.
Yoshinori Asakawa Masao Toyota Reiji Takeda Claude Suire Tsunematsu Takemoto 《Phytochemistry》1981,20(4):725-728
Riccardia species (Metzgeriales) contain various types of sesquiterpenes. R. jackii produces ent-selinane-, ent-aromadendrane-and ent-bicyclogermacrane-type sesquiterpenes together with (R)-cuparene and α-barbatene. Aneura pinguis (= Riccardia pinguis) is chemically quite different from R. multifida and R. jackii. The former produces a large amount of pinguisone. R. multifida contains 6-(3-methyl-2-butenyl)-indole and (+)-β-elemene as the major components. Pallavicinia longispina (Dilaenaceae; Metzgeriales) produces mainly spathulenol. The chiral properties of the sesquiterpenes isolated from R. jackii are quite similar to those of red algae, Laurencia species. 相似文献
83.
Undifferentiated Friend erythroleukemic cells (FL cells) acquire membrane microviscosity (
), in accord with the culture cell density. At low cell density
poise, whereas at confluency it increases to
poise. Concomitantly, the total number of available transferrin receptors per cell decreases by about 80% upon increase in
cell density. Modulation of membrane microviscosity, by artificial alteration of the membrane cholesterol level, mediates
similar modulations of the availability of the transferrin receptors. The correlation between the availability of the transferrin
receptors and the membrane lipid fluidity may take part in the overt decrease in iron uptake by erythroid cells along the
erythropoiesis pathway. 相似文献
84.
Robert L. Wykle Craig H. Miller Jon C. Lewis Jeffrey D. Schmitt Jennie A. Smith Jefferson R. Surles Claude Piantadosi Joseph T. OFlaherty 《Biochemical and biophysical research communications》1981,100(4):1651-1658
1-O-Hexadecyl-2-O-acetyl--glycero-3-phosphocholine (platelet activating factor) stimulated the degranulation of rabbit platelets and human neutrophils, whereas the enantiomer, 3-O-hexadecyl-2-O-acetyl--glycero-1-phosphocholine, was inactive. The analogs compared had the following relative potencies in degranulating platelets and neutrophils: 1-O-hexadecyl-2-O-acetyl--glycero-3-phosphocholine > 1-O-hexadecyl-2-O-ethyl--glycero-3-phosphocholine >-1-O-octadecyl-2-O-ethylglycero-3-phosphocholine = 1-O-hexadecyl-2-O-methyl--glycero-3-phosphocholine >-1-O-dodecyl-2-O-ethyl-glycero-3-phosphocholine. The deacetylated compound, 1-O-hexadecyl-2-lyso--glycero-3-phosphocholine, and 1-O-hexadecyl-2,2-dimethylpropanediol-3-phosphocholine were inactive. The active analogs selectively desensitized the response to each other in the neutrophils. It is suggested that these compounds may activate cells through interaction with a stereospecific receptor. 相似文献
85.
Claude Auriault Joël Pestel Michel Joseph Jean-Paul Dessaint Andre Capron 《Cellular immunology》1981,62(1):15-27
Discharge of lysosomal enzymes, measured by release of β-glucuronidase and cytotoxicity against Schistosoma mansoni schistosomula, was studied when rat macrophages were incubated in the presence of either IgG peptides, resulting from the cleavage of nonimmune IgG by parasitic proteases, or nonimmune aggregated IgG. With peptides, the macrophage activity showed a dramatic decrease while they were stimulated by IgG aggregates. In contrast, the synthesis of lymphocyte activating factor by macrophages was unaffected. The hydrolysis of IgG is carried out by two distinct enzymatic molecules released into the medium by the larvae. The mechanism by which nonimmune IgG peptides or aggregates inhibit or stimulate macrophage activity, regulated by both parameters indicated above, is discussed and is suggested as a general regulation mechanism for the macrophage activity required for parasite survival in the host. 相似文献
86.
Nucleocytoplasmic Relations in a Mutator-Suppressor System of DROSOPHILA ANANASSAE 总被引:1,自引:1,他引:0 下载免费PDF全文
Claude W. Hinton 《Genetics》1981,98(1):77-90
A partially characterized mutator-suppressor system, previously identified in the ca; stw stock of Drosophila ananassae, was shown to exist in the ca ancestral stock; it consists of a clastogenic mutator of sperm chromosomes and a supressor that functions in the oöcyte soon after fertilization. Transmission of these components was monitored by Minute mutation frequencies produced by the progeny of recurrently backcrossed hybrid females derived from reciprocal outcrosses of the ca stock. In this way, the mutator was shown to be an extrachromosomally transmitted element whose propagation depends upon nuclear genes. Suppressivity was found to be determined by nuclear genes, some of which are expressed only after a delay of several generations. Neither the mutator nor its suppressor appear to be infectious. Measurement of dominant lethal frequencies showed that the suppressor is completely effective in repair of premutational lesions induced by the mutator. The properties of this mutator-suppressor system were compared with those of hybrid dysgenesis in Drosophila melanogaster. 相似文献
87.
The first mammalian remain ever found in NewCaledonia is an upper tooth found by golddiggers in the Plio-Pleistocene terrace from the Diahot river. This tooth, given to the Muséum national d'Histoire naturelle (Paris) in 1876, was determined as a rhinoceros tooth and then completely forgotten. Its detailed study shows that it belongs to Zygomaturus, a large marsupial diprotodontid genus whose story is rather complicated. The Diahot tooth represents a new species of Zygomaturus, Z. diahotensis nov. sp., close to Z. trilobus from the Australian Pleistocene. That kinship suggests a Plio-Pleistocene land connection between Australia and New Caledonia, whereas till now New Caledonia was supposed to be separated from Australia since the end of the Cretaceous, because of the total absence of indigenous mammals, fossil or recent, in New Caledonia. The latest geological studies in the East Pacific do not contradict our hypothesis. 相似文献
88.
Claude E. Boyd 《Hydrobiologia》1981,80(1):91-93
Ion-pairing has little effect on ionic activity calculations for weakly mineralized natural water (ionic strength < 2 mM). However, for more strongly mineralized freshwaters, corrections for ion-pairing are necessary if highly accurate ionic activities are required. 相似文献
89.
90.