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131.
132.
Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not against sulphamethoxazole. Co-trimoxazole is a potent antimicrobial agent and is advocated for treatment and prophylaxis in leukaemia. Hence its adverse effect on platelets is of great importance. 相似文献
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In this study a proteomic approach was used to investigate the steady-state response of Escherichia coli to temperature up-shifts in a cascade of two continuously operated bioreactors. The first reactor served as cell source with
optimal settings for microbial growth, while in the second chemostat the cells were exposed to elevated temperatures. By using
this reactor configuration, which has not been reported to be used for the study of bacterial stress responses so far, it
is possible to study temperature stress under well-defined, steady-state conditions. Specifically the effect on the cellular
adaption to temperature stress using two-dimensional gel electrophoresis was examined and compared at the cultivation temperatures
of 37°C and 47.5°C. As expected, the steady-state study with the double bioreactor configuration delivered a different protein
spectrum compared to that obtained with standard batch experiments in shaking flasks and bioreactors. Setting a high cut-out
spot-to-spot size ratio of 5, proteins involved in defence against oxygen stress, functional cell envelope proteins, chaperones
and proteins involved in protein biosynthesis, the energy metabolism and the amino acid biosynthesis were found to be differently
expressed at high cultivation temperatures. The results demonstrate the complexity of the stress response in a steady-state
culture not reported elsewhere to date. 相似文献
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Rates of single-copy DNA evolution in herons 总被引:2,自引:1,他引:1
DNA-DNA hybridization was used to discover the extent of single-copy DNA
similarity among 13 species of herons and one ibis. Genetic distances among
taxa were summarized as Tm values in a folded matrix. From this matrix,
trees with the same branching pattern were constructed by least squares
under one of two assumptions: (1) that sister branches are equal in length
and (2) that sister branches are not necessarily equal in length. The
residual sums of squares of these trees were compared by F-test to see
whether the branches of the tree built under assumption (2) fit the matrix
data significantly better than those of the tree built under assumption
(1). By this method the existence of different rates of DNA evolution in
different heron lineages was established. Bittern single-copy DNA has
evolved at a rate approximately 25% faster, and boat-billed heron
(Cochearius) and rufescent tiger heron (Tigrisoma lineatum) DNA has evolved
approximately 19% slower, than that of day and night herons. It appears
that the differences in rates of DNA evolution may increase proportionally
with genealogical distance.
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