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排序方式: 共有675条查询结果,搜索用时 15 毫秒
671.
672.
Feline W Lindhout Sybren Portegies Robbelien Kooistra Lotte J Herstel Riccardo Stucchi Jessica J A Hummel Nicky Scheefhals Eugene A Katrukha Maarten Altelaar Harold D MacGillavry Corette J Wierenga Casper C Hoogenraad 《The EMBO journal》2021,40(10)
Axon formation critically relies on local microtubule remodeling and marks the first step in establishing neuronal polarity. However, the function of the microtubule‐organizing centrosomes during the onset of axon formation is still under debate. Here, we demonstrate that centrosomes play an essential role in controlling axon formation in human‐induced pluripotent stem cell (iPSC)‐derived neurons. Depleting centrioles, the core components of centrosomes, in unpolarized human neuronal stem cells results in various axon developmental defects at later stages, including immature action potential firing, mislocalization of axonal microtubule‐associated Trim46 proteins, suppressed expression of growth cone proteins, and affected growth cone morphologies. Live‐cell imaging of microtubules reveals that centriole loss impairs axonal microtubule reorganization toward the unique parallel plus‐end out microtubule bundles during early development. We propose that centrosomes mediate microtubule remodeling during early axon development in human iPSC‐derived neurons, thereby laying the foundation for further axon development and function. 相似文献
673.
Vihren Chakarov Sibylla Hummel Florian Losch Jürgen Schulte-Mönting Rumyana Kristeva 《BMC neurology》2006,6(1):14-7
Background
The present study was aimed at investigating the writing parameters of writer's cramp patients and control subjects during handwriting of a test sentence in the absence of visual control. 相似文献674.
675.
Genetic and some ecophysiological traits of mussels collected in the European Arctic, up to their northeastern distribution
limit in the Barents Sea, were studied and compared with traits of mussels from the Mediterranean, Atlantic and Baltic. The
genetic traits of these populations were analysed by isoenzyme electrophoresis on seven loci in order to assess the Mytilus complex to which populations in the Arctic region belong. Ecophysiological variables, the weight-index and glycogen were
analysed to assess the physiological fitness of the populations. Three distinct groups were recognised: (1) Mytilus (edulis) galloprovincialis in the Mediterranean and Spain, (2) M. (edulis) edulis along the Atlantic coast from the Netherlands northwards into Russia, and (3) the Baltic Mytilus (edulis) trossulus. The mussels from populations in the Russian Arctic all belong to the Atlantic Mytilus (edulis) edulis group. The genetic variability and ecophysiological measures indicated that the sub-Arctic White Sea mussel populations have
a relatively lower performance capacity, whereas those in the Arctic at the edge of their northern distribution showed a surprisingly
strong performance.
Accepted: 14 June 2000 相似文献