全文获取类型
收费全文 | 3597篇 |
免费 | 223篇 |
国内免费 | 176篇 |
出版年
2024年 | 7篇 |
2023年 | 60篇 |
2022年 | 156篇 |
2021年 | 271篇 |
2020年 | 189篇 |
2019年 | 231篇 |
2018年 | 219篇 |
2017年 | 150篇 |
2016年 | 227篇 |
2015年 | 293篇 |
2014年 | 370篇 |
2013年 | 382篇 |
2012年 | 358篇 |
2011年 | 330篇 |
2010年 | 166篇 |
2009年 | 126篇 |
2008年 | 131篇 |
2007年 | 101篇 |
2006年 | 70篇 |
2005年 | 48篇 |
2004年 | 38篇 |
2003年 | 23篇 |
2002年 | 17篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 5篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1959年 | 2篇 |
排序方式: 共有3996条查询结果,搜索用时 15 毫秒
21.
Zhengyun Zou Qiuxiang Ou Yu Ren Qing Lv Lanqun Qin Lianjun Zhao Shu Su Xue Wu Hua Bao Ao Wang Dongqin Zhu Xiaonan Wang Yang W. Shao Baorui Liu 《Pigment cell & melanoma research》2020,33(4):601-611
The incidence of melanoma is rising globally including China. Comparing to Caucasians, the incidence of non‐cutaneous melanomas is significantly higher in Chinese. Herein, we performed genomic profiling of 89 Chinese surgically resected primary melanomas, including acral (n = 54), cutaneous (n = 22), and mucosal (n = 13), by hybrid capture‐based next‐generation sequencing. We show that mucosal melanomas tended to harbor more pathogenic mutations than other types of melanoma, though the biological significance of this finding remains uncertain. Chromosomal arm‐level alterations including 6q, 9p, and 10p/q loss were highly recurrent in all subtypes, but mucosal melanoma was significantly associated with increased genomic instability. Importantly, 7p gain significantly correlated with unfavorable clinical outcomes in non‐cutaneous melanomas, representing an intriguing prognostic biomarker of those subtypes. Furthermore, focal amplification of 4q12 (KIT, KDR, and PDGFRα) and RAD51 deletion were more abundant in mucosal melanoma, while NOTCH2 amplification was enriched in acral melanoma. Additionally, cutaneous melanomas had higher mutation load than acral melanomas, while mucosal melanomas did not differ from other subtypes in mutation burden. Together, our data revealed important features of acral and mucosal melanomas in Chinese including distinctive driver mutation pattern and increased genomic instability. These findings highlight the possibilities of combination therapies in the clinical management of melanoma. 相似文献
22.
23.
24.
Qundan Lv Jie Qiu Jie Liu Zheng Li Wenting Zhang Qin Wang Jie Fang Junjie Pan Zhengdao Chen Wenliang Cheng Michael S. Barker Xuehui Huang Xin Wei Kejun Cheng 《The Plant journal : for cell and molecular biology》2020,103(5):1910-1923
Chimonanthus salicifolius, a member of the Calycanthaceae of magnoliids, is one of the most famous medicinal plants in Eastern China. Here, we report a chromosome‐level genome assembly of C. salicifolius, comprising 820.1 Mb of genomic sequence with a contig N50 of 2.3 Mb and containing 36 651 annotated protein‐coding genes. Phylogenetic analyses revealed that magnoliids were sister to the eudicots. Two rounds of ancient whole‐genome duplication were inferred in the C. salicifolious genome. One is shared by Calycanthaceae after its divergence with Lauraceae, and the other is in the ancestry of Magnoliales and Laurales. Notably, long genes with > 20 kb in length were much more prevalent in the magnoliid genomes compared with other angiosperms, which could be caused by the length expansion of introns inserted by transposon elements. Homologous genes within the flavonoid pathway for C. salicifolius were identified, and correlation of the gene expression and the contents of flavonoid metabolites revealed potential critical genes involved in flavonoids biosynthesis. This study not only provides an additional whole‐genome sequence from the magnoliids, but also opens the door to functional genomic research and molecular breeding of C. salicifolius. 相似文献
25.
26.
27.
Zhang Keji Gao Yuan Deng Yuxiao Zhou Xiao Zhu Changqing He Zhengyu Lv Dan 《Molecular and cellular biochemistry》2021,476(1):93-107
Molecular and Cellular Biochemistry - Mesenchymal stem cells (MSCs) can alleviate acute respiratory distress syndrome (ARDS), but the mechanisms involved are unclear, especially about their... 相似文献
28.
Cao Yongxian Zhang Feng Wang Haotian Bi Chunhua Cui Jinpeng Liu Fenghai Pan Huazheng 《Molecular and cellular biochemistry》2021,476(1):279-292
Molecular and Cellular Biochemistry - Drug resistance is one of the major challenges for cancer therapies. In recent years, research on disease-related molecular signaling pathways has become the... 相似文献
29.
Chen Qiumin Yu Guangchao Wang Xiangyu Meng Xiangnan Lv Chunmao 《Journal of Plant Growth Regulation》2021,40(1):147-153
Journal of Plant Growth Regulation - Powdery mildew (PM) is one of the most severe foliar diseases in cucumbers (Cucumis sativus L.), but the inheritance of PM resistance remains unclear. The... 相似文献
30.
Ji Ruiqin Gao Shiqi Bi Qing Wang Yilian Lv Mingcan Ge Wenjie Feng Hui 《Journal of Plant Growth Regulation》2021,40(1):405-422
Journal of Plant Growth Regulation - Clubroot disease, caused by Plasmodiophora brassicae Woronin infection, leads to significant yield and economic losses in cruciferous vegetables. However, the... 相似文献