Polymorphic gene markers of lipid metabolism are associated with diabetic nephropathy in patients with type 1 diabetes mellitus

In groups of type 1 diabetes mellitus patients with and without clinical signs of diabetic nephropathy (n = 62 and n = 68, respectively), a search was made for associations between diabetic nephropathy and the polymorphic marker epsilon2/epsilon3/epsilon4 of apolipoprotein E gene (APOE), I/D marker of apolipoprotein B gene (APOB), and Ser447Ter marker of lipoprotein lipase-encoding gene (LPL). The risk of diabetic nephropathy was higher in the carriers of allele epsilon3 and genotype epsilon3/epsilon3 of the polymorphic marker epsilon2/epsilon3/epsilon4 of APOE gene as well as in the carriers of allele 1 and APOB genotype/gene (OR = 2.08 and 2.16; 1.91 and 2.11, respectively). Conversely, the carriers of allele D showed a reduced risk of this complication (OR = 0.52). No significant differences in distribution of alleles and genotypes of the polymorphic marker Ser447Ter of LPL gene were found between the groups. Our results indicate that the genes encoding two major components of lipid metabolism are involved in the development of diabetic nephropathy in patients with type 1 diabetes mellitus.     

Component communities of parasites and interaction of the parasitic faunas of noncommercial fishes in the Kacha River (Yenisei Basin)

The work is the first to determine the structure of the communities of parasites of the noncommercial fish species in the Kacha River (Yenisei tributary). The studied communities are formed primarily with the generalist species (68%) with an insignificant share (16%) of the specialist species. Only one species (Trichodinella epizootica Raabe, 1950) with the occurrence >70% is attributed to the primary occurring species, and three, to the secondary (Paratrichodina incisa, Lom, 1959, Diplostomum phoxini Faust, 1918, Rhabdochona denudata (Dujardin, 1945)). All remaining species (46) are additional. The characteristic feature of the parasitic fauna of the fishes in Kacha is the extremely low Jaccard similarity coefficients, which indicates the peculiarity of the ecological niches of the studied hosts.     

The Structure of Parasite Communities in the European Perch (Perca fluviatilis L.) in the Initial Period of the Formation of Boguchanskoe Reservoir

Biology Bulletin - The first study of ecological and populational changes in the species richness and diversity of parasitic communities of European perch Perca fluviatilis (L. 1758) during the...