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941.
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气道高反应的发病机制目前仍然不清楚,但人多数人认同是气道的一种慢性炎症。近十年来,上皮缺陷学说逐渐成为解释气道高反应机制的主流观点。气道上皮不再被仅仅看作为单纯的机械屏障,而是机体内环境与外部环境相互作用的界面。气道上皮具有广泛的生理作用,包括抗氧化、内分泌和外分泌、黏液运输、生物代谢、结构性黏附、损伤修复、应激或炎症信号传递、抗原递呈作用等。借助这些生理作用,支气管上皮细胞在气道局部微环境稳态维持中发挥重要作用。有理由相信,气道上皮的结构完整性缺陷或功能紊乱是哮喘和慢性阻塞性肺疾病等气道高反应性疾病的启动环节。 相似文献
945.
1999~2000年在内蒙古草原区的中温型草原和暖温型草原两个研究站点, 分别对大针茅(Stipa grandis)、羊草(Leymus chinensis)、糙隐子草(Cleistogenes squarrosa)、达乌里胡枝子(Lespedeza dahurica)和阿尔泰狗哇花(Heteropappus altaicus) 5个共有种地上生物量、营养元素(全C、全N、全P)和能量(热值)的繁殖分配进行了初步研究。结果表明:两站点共有种各自的地上生物量、全C 和能量之间的繁殖分配较为接近,但全P、全N 相似文献
946.
Hio‐Ieng Un Shawn A. Gregory Swagat K. Mohapatra Miao Xiong Elena Longhi Yang Lu Sergei Rigin Samik Jhulki Chi‐Yuan Yang Tatiana V. Timofeeva Jie‐Yu Wang Shannon K. Yee Stephen Barlow Seth R. Marder Jian Pei 《Liver Transplantation》2019,9(24)
Molecular doping is a powerful method to fine‐tune the thermoelectric properties of organic semiconductors, in particular to impart the requisite electrical conductivity. The incorporation of molecular dopants can, however, perturb the microstructure of semicrystalline organic semiconductors, which complicates the development of a detailed understanding of structure–property relationships. To better understand how the doping pathway and the resulting dopant counterion influence the thermoelectric performance and transport properties, a new dimer dopant, (N‐DMBI)2, is developed. Subsequently, FBDPPV is then n‐doped with dimer dopants (N‐DMBI)2, (RuCp*mes)2, and the hydride‐donor dopant N‐DMBI‐H. By comparing the UV–vis–NIR absorption spectra and morphological characteristics of the doped polymers, it is found that not only the doping mechanism, but also the shape of the counterion strongly influence the thermoelectric properties and transport characteristics. (N‐DMBI)2, which is a direct electron‐donating dopant with a comparatively small, relatively planar counterion, gives the best power factor among the three systems studied here. Additionally, temperature‐dependent conductivity and Seebeck coefficient measurements differ between the three dopants with (N‐DMBI)2 yielding the best thermoelectric properties. The results of this study of dopant effects on thermoelectric properties provide insight into guidelines for future organic thermoelectrics. 相似文献
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948.
Bin Wang Ting-yu Liu Chun-Hsiang Lai Yan-hua Rao Moon-Chang Choi Jen-Tsan Chi Jian-wu Dai Jeffrey C. Rathmell Tso-Pang Yao 《Molecular biology of the cell》2014,25(21):3300-3307
Activation of the inflammatory response is accompanied by a metabolic shift to aerobic glycolysis. Here we identify histone deacetylase 4 (HDAC4) as a new component of the immunometabolic program. We show that HDAC4 is required for efficient inflammatory cytokine production activated by lipopolysaccharide (LPS). Surprisingly, prolonged LPS treatment leads to HDAC4 degradation. LPS-induced HDAC4 degradation requires active glycolysis controlled by GSK3β and inducible nitric oxide synthase (iNOS). Inhibition of GSK3β or iNOS suppresses nitric oxide (NO) production, glycolysis, and HDAC4 degradation. We present evidence that sustained glycolysis induced by LPS treatment activates caspase-3, which cleaves HDAC4 and triggers its degradation. Of importance, a caspase-3–resistant mutant HDAC4 escapes LPS-induced degradation and prolongs inflammatory cytokine production. Our findings identify the GSK3β-iNOS-NO axis as a critical signaling cascade that couples inflammation to metabolic reprogramming and a glycolysis-driven negative feedback mechanism that limits inflammatory response by triggering HDAC4 degradation. 相似文献
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950.
Dong Ju Lee Youn-Tae Chi Dong Min Kim Seung-Hyun Choi Ji Young Lee Go-woo Choi 《Plant molecular biology》2014,86(3):255-270
In a previous report, the pepper receptor-like kinase 1 (CaRLK1) gene was shown to be responsible for negatively regulating plant cell death caused by pathogens via accumulation of superoxide anions. Here, we examined whether this gene also plays a role in regulating cell death under abiotic stress. The total concentrations of free amino acids in CaRLK1-overexpressed cells (RLKox) increased by twofold compared with those of the wild-type Nicotiana tabacum BY-2 cells. Additionally, alanine and pyruvate concentrations increased by approximately threefold. These accumulations were associated with both the expression levels of the isocitrate lyase (ICL) and malate synthase genes and their specific activities, which were preferentially up-regulated in the RLKox cells. The expression levels of ethylene biosynthetic genes (ACC synthase and ACC oxidase) were suppressed, but those of both the metallothionein and lesion simulating disease 1 genes increased in the RLKox cells during submergence-induced hypoxia. The specific activity of catalase, which is involved in protecting ICL from reactive oxygen species, was also induced threefold in the RLKox cells. The primary roots of the transgenic plants that were exposed to hypoxic conditions grew at similar rates to those in normal conditions. We propose that CaRLK1 maintains a persistent hypoxia-resistant phenotype. 相似文献