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Daw-Yang Hwang Stefan Kohl Xueping Fan Asaf Vivante Stefanie Chan Gabriel C. Dworschak Julian Schulz Albertien M. van Eerde Alina C. Hilger Heon Yung Gee Tracie Pennimpede Bernhard G. Herrmann Glenn van de Hoek Kirsten Y. Renkema Christoph Schell Tobias B. Huber Heiko M. Reutter Neveen A. Soliman Natasa Stajic Radovan Bogdanovic Elijah O. Kehinde Richard P. Lifton Velibor Tasic Weining Lu Friedhelm Hildebrandt 《Human genetics》2015,134(8):905-916
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Larissa Albantakis Arend Hintze Christof Koch Christoph Adami Giulio Tononi 《PLoS computational biology》2014,10(12)
Natural selection favors the evolution of brains that can capture fitness-relevant features of the environment''s causal structure. We investigated the evolution of small, adaptive logic-gate networks (“animats”) in task environments where falling blocks of different sizes have to be caught or avoided in a ‘Tetris-like’ game. Solving these tasks requires the integration of sensor inputs and memory. Evolved networks were evaluated using measures of information integration, including the number of evolved concepts and the total amount of integrated conceptual information. The results show that, over the course of the animats'' adaptation, i) the number of concepts grows; ii) integrated conceptual information increases; iii) this increase depends on the complexity of the environment, especially on the requirement for sequential memory. These results suggest that the need to capture the causal structure of a rich environment, given limited sensors and internal mechanisms, is an important driving force for organisms to develop highly integrated networks (“brains”) with many concepts, leading to an increase in their internal complexity. 相似文献
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Ugur Sahin Sylvia Kraft-Bauer Sascha Ohnesorge M. Pfreundschuh Christoph Renner 《Cancer immunology, immunotherapy : CII》1996,42(1):9-14
The combination of CD16/CD30 bispecific monoclonal antibodies (bi-mAb) and unstimulated human resting natural killer (NK)
cells can cure about 50% of mice with severe combined immunodeficiency (SCID) bearing subcutaneously growing established Hodgkin’s
lymphoma. As interleukin-2 (IL-2) and IL-12 have been shown to increase NK cell activity, we tested the capacity of these
cytokines to increase bi-mAb-mediated NK cell cytotoxicity against two types of human tumors (Hodgkin’s disease and colorectal
carcinoma). Unstimulated NK cells needed a three- to five-times higher antibody concentration than cytokine-stimulated NK
cells to exert similar levels of bi-mAb-mediated cytotoxicity. The augmented tumor cell lysis was achieved with IL-12 at considerably
lower concentrations than with IL-2 and was associated with a significantly increased bi-mAb-mediated intracellular Ca2+ mobilization. The efficiency of IL-12 in this setting together with its low toxicity make it the ideal candidate for a combination
therapy with NK-cell-activating bi-mAb in human tumors that are resistant to standard treatment.
Received: 26 July 1995 / Accepted: 16 November 1995 相似文献
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