Synthesis and anti-ulcer activity of 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1

( )-11-Deoxy-16-phenoxy-17,18,19,20-tetranor-prostaglandin E₁ is a highly potent and selective anti-ulcer agent. Analogues of this compound have been synthesized and structure-activity relationships are reported.     

Radiation chemistry of high-energy carbon, neon, and argon ions: hydroxyl radical yields

Chemical yields of H2O2 have been measured from aerated aqueous solutions of bromide and of formate irradiated at various pHs and solute concentrations with high-energy ions from the Berkeley Bevalac. Hydroxyl radical yields have been deduced from these data as a function of beam penetration into the solutions. By taking fragmentation of the primary ions into account, estimates of the instantaneous Gi OH values for the primary beams as a function of their energy have been made.