双特异性抗体在肿瘤治疗中的研究

双特异性抗体(bispecific antibody,BsAb)有两个抗原结合位点,其中一个位点可与靶细胞表面抗原结合,另一个位点则可与载荷物(如效应细胞,分子等)结合。将BsAb应用于肿瘤治疗,发挥抗肿瘤效应的思想已有二十多年历史,随着对效应细胞生物学了解的加深和抗体工程的飞速发展,各种形式的BsAb相继出现,多种BsAb药物已进入临床初期试验或治疗使用阶段。本文就BsAb的各种新形式及其在肿瘤治疗中的应用新进展作简要概述。     

DSA图像中运动伪影的消除方法

由于病人存在着各种运动(如呼吸、肌肉运动、心脏运动、设备噪声),在成像过程中常会造成图像上出现伪影,干扰医生的正常诊断,为消除这种伪影,本文提出一种基于图像配准思想的全自动消除伪影的方法,该方法能够自动消除DSA图像中的大部分运动伪影,使DSA图像得到较好的增强,并为后面的血管分割和三维重建提供便利,是一种快速有效的方法。     

Length–weight relationships for 85 fish species from Guam

Length–weight relationships (LWRs) were developed for 85 reef and bottom‐fish species from Guam. These are the first published LWRs for Guam, and include new LWRs for nine species lacking these relationships in FishBase.     

Efficiently Tracking Selection in a Multiparental Population: The Case of Earliness in Wheat

Multiparental populations are innovative tools for fine mapping large numbers of loci. Here we explored the application of a wheat Multiparent Advanced Generation Inter-Cross (MAGIC) population for QTL mapping. This population was created by 12 generations of free recombination among 60 founder lines, following modification of the mating system from strict selfing to strict outcrossing using the ms1b nuclear male sterility gene. Available parents and a subset of 380 SSD lines of the resulting MAGIC population were phenotyped for earliness and genotyped with the 9K i-Select SNP array and additional markers in candidate genes controlling heading date. We demonstrated that 12 generations of strict outcrossing rapidly and drastically reduced linkage disequilibrium to very low levels even at short map distances and also greatly reduced the population structure exhibited among the parents. We developed a Bayesian method, based on allelic frequency, to estimate the contribution of each parent in the evolved population. To detect loci under selection and estimate selective pressure, we also developed a new method comparing shifts in allelic frequency between the initial and the evolved populations due to both selection and genetic drift with expectations under drift only. This evolutionary approach allowed us to identify 26 genomic areas under selection. Using association tests between flowering time and polymorphisms, 6 of these genomic areas appeared to carry flowering time QTL, 1 of which corresponds to Ppd-D1, a major gene involved in the photoperiod sensitivity. Frequency shifts at 4 of 6 areas were consistent with earlier flowering of the evolved population relative to the initial population. The use of this new outcrossing wheat population, mixing numerous initial parental lines through multiple generations of panmixia, is discussed in terms of power to detect genes under selection and association mapping. Furthermore we provide new statistical methods for use in future analyses of multiparental populations.     

鸡胚内抗氧化物质的分布与变化

生物体内存在多种内源性抗氧化物质,在生命过程中发挥着基本的防御功能,是人们十分关注的研究领域。本文综述了近年来鸡胚内抗氧化物质的形成与来源等研究成果,分析了鸡胚孵育过程中维生素(A、C、E)、类胡萝卜素、硒、过氧化氢酶和超氧化物歧化酶等主要抗氧化物质的分布与变化,及内源性抗氧化系统的形成,旨在为今后的研究提供有益的科学依据。     

RNA干扰在疾病治疗上的应用

RNA干扰(RNA interference,RNAi)是一种双链RNA分子在mRNA水平上引发的特异性基因沉默现象。RNAi在基因治疗方面表现出了光明的前景,已成功地应用于多种疾病的临床治疗。本文主要介绍了RNAi在疾病治疗上的应用及研究进展。     

Ilyocypris bradyi的轮廓分析

本文试图通过对若尔盖盆地晚新生代非海相介形类化石Ilyocypris bradyi(Sars)的轮廓分析来介绍几何形态测量法在介形类化石的形态分析中的应用。分析对比后发现,虽然Ilyocypris bradyi(Sars)居群内的个体在形态上存在或多或少的差异,但这些差异之间存在连续过渡的关系,并未出现明显的分异,说明此种的种内变异是连续的。     

西藏台错古湖晚第四纪轮藻类及其生态环境、气候变化探讨

西藏台错TT-1剖面厚369 cm,为一套碳酸盐粘土和粘土碳酸盐沉积,地层测年为41.4-4.5 ka,含丰富的轮藻化石,分属于11个轮藻植物群,群落所在地层的碳酸盐和钙质含量分别为80％和33％.从老到新(剖面自下而上):①41.4-26.64 ka(369-319 cm),处于末次冰期间冰阶MIS3a暖期,湖区气候...     

基因突变在结直肠癌发生机制中的作用:殊途同归

结直肠癌的多步骤演进模式一直是肿瘤研究的经典,在这一过程中,序贯发生的基因突变(或其它遗传事件)是重要的推动力。本文综述了在结直肠癌中检测到的基因突变情况,并分析了在新一代测序技术的带动下,结直肠癌基因组学的最新进展。结直肠癌组织基因突变的地形图理念对于今后的肿瘤分子诊疗将具有重要意义。肿瘤不仅是基因病,更是信号通路异常病。     

广西蕨类植物孢子形态的研究Ⅲ.凤尾蕨科

利用光学显微镜和扫描电子显微镜对广西产凤尾蕨科及其近缘科蕨科、姬蕨科和碗蕨科5属9种植物的孢子形态进行了观察研究,详细描述了9种植物孢子的形态及表面纹饰特征.井栏边草、刺齿凤尾蕨、隆林凤尾蕨、剑叶凤尾蕨、林下凤尾蕨、蕨和碗蕨植物的孢子为三裂缝,辐射对称;极面观为钝三角形,赤道面观为半圆形或超半圆形;栗蕨和姬蕨植物孢子为...