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排序方式: 共有321条查询结果,搜索用时 343 毫秒
191.
Rob Jelier Guido Jenster Lambert CJ Dorssers Bas J Wouters Peter JM Hendriksen Barend Mons Ruud Delwel Jan A Kors 《BMC bioinformatics》2007,8(1):14
Background
High-throughput experiments, such as with DNA microarrays, typically result in hundreds of genes potentially relevant to the process under study, rendering the interpretation of these experiments problematic. Here, we propose and evaluate an approach to find functional associations between large numbers of genes and other biomedical concepts from free-text literature. For each gene, a profile of related concepts is constructed that summarizes the context in which the gene is mentioned in literature. We assign a weight to each concept in the profile based on a likelihood ratio measure. Gene concept profiles can then be clustered to find related genes and other concepts. 相似文献192.
Background
The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association.Results
Here, we present HLA-E allele haplotype association and population linkage disequilibrium (LD) analysis within the ~1.3 Mb bounded by HLA-B/Cw and HLA-A to increase the resolution of identified class I haplotypes. Through local breakdown of LD, we inferred ancestral recombination points both upstream and downstream of HLA-E contributing to alternative block structures within previously identified haplotypes. Through single nucleotide polymorphism (SNP) analysis of the MHC region, we also confirmed the essential genetic fixity, previously inferred by MHC allele analysis, of three conserved extended haplotypes (CEHs), and we demonstrated that commercially-available SNP analysis can be used in the MHC to help define CEHs and CEH fragments.Conclusion
We conclude that to generate high-resolution maps for relating MHC haplotypes to disease susceptibility, both SNP and MHC allele analysis must be conducted as complementary techniques. 相似文献193.
194.
Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration 总被引:1,自引:0,他引:1
Tuan HN Nguyen Mathieu JM Bertrand Christiane Sterpin Younes Achouri Olivier RY De Backer 《BMC cell biology》2010,11(1):57
Background
In normal adult skeletal muscle, cell turnover is very slow. However, after an acute lesion or in chronic pathological conditions, such as primary myopathies, muscle stem cells, called satellite cells, are induced to proliferate, then withdraw definitively from the cell cycle and fuse to reconstitute functional myofibers. 相似文献195.
196.
Evolution of SINE S1 retroposons in Cruciferae plant species 总被引:3,自引:0,他引:3
Lenoir A; Cournoyer B; Warwick S; Picard G; Deragon JM 《Molecular biology and evolution》1997,14(9):934-941
The S1 element is a plant short interspersed element (SINE) that was first
described and studied in Brassica napus. In this work, we investigated the
distribution and the molecular phylogeny of the S1 element within the
Cruciferae (= Brassicaceae). S1 elements were found to be widely
distributed within the Cruciferae, especially in species of the tribe
Brassiceae. The molecular phylogeny of S1 elements in eight Cruciferae
species (Brassica oleracea, Brassica rapa, Brassica napus, Brassica nigra,
Sinapis, arvensis, Sinapis pubescens, Coincya monensis, and Vella spinosa)
was inferred using 14-36 elements per species. Significant neighbor-joining
and maximum-parsimony phylogenetic clusters, supported by high bootstrap P
values and/or represented in 100% of the most-parsimonious trees, were
observed for each species. Most of these clusters probably correspond to
recent species-specific bursts of S1 amplification. Since these species
diverged recently, S1 amplification in Cruciferae plants is proposed to be
a highly dynamic process that could contribute to genome rearrangements and
eventually lead to reproductive isolation. S1 sequence analysis also
revealed putative gene conversion events that occurred between different S1
elements of a given species. These events suggest that gene conversion is a
minor but significant component of the molecular drive governing S1
concerted evolution.
相似文献
197.
198.
199.
Jörg Barke Ryan F Seipke Sabine Grüschow Darren Heavens Nizar Drou Mervyn J Bibb Rebecca JM Goss Douglas W Yu Matthew I Hutchings 《BMC biology》2010,8(1):109
Background
Attine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and with antibiotic-producing actinomycete bacteria. One hypothesis suggests that bacteria from the genus Pseudonocardia are the sole, co-evolved mutualists of attine ants and are transmitted vertically by the queens. A recent study identified a Pseudonocardia-produced antifungal, named dentigerumycin, associated with the lower attine Apterostigma dentigerum consistent with the idea that co-evolved Pseudonocardia make novel antibiotics. An alternative possibility is that attine ants sample actinomycete bacteria from the soil, selecting and maintaining those species that make useful antibiotics. Consistent with this idea, a Streptomyces species associated with the higher attine Acromyrmex octospinosus was recently shown to produce the well-known antifungal candicidin. Candicidin production is widespread in environmental isolates of Streptomyces, so this could either be an environmental contaminant or evidence of recruitment of useful actinomycetes from the environment. It should be noted that the two possibilities for actinomycete acquisition are not necessarily mutually exclusive. 相似文献200.