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131.
Kusumegi T Tanaka J Kawano M Yonemoto J Tohyama C Sone H 《Journal of biochemical and molecular toxicology》2004,18(1):1-11
A ligand-receptor pair, bone morphogenetic protein-7 (BMP7) and activin receptor IIB (actRIIB), was identified from a pool of DNA fragments recovered from MCF7 cells treated with 17beta-estradiol (E2) by chromatin immunoprecipitation with antiestrogen receptor-alphaantibody. The E2 responsiveness of both genes was confirmed in MCF cells and in the mouse uterus. Repeated treatment with E2 resulted in decreased expression of both actRIIB and BMP7 mRNA in the uteri of ovariectomized mice. A single oral administration of bisphenol A (BPA), an environmental estrogen, inhibited actRIIB and BMP7 expression and apoptosis in the luminal epithelium of the mouse uterus at diestrus (or early proestrus). This decrease, due to BPA administration, was restored by an estrogen receptor (ER) antagonist suggesting that it is mediated through ERs. These results suggest that E2 and BPA suppress estrogen-dependent apoptosis of epithelial cells of the endometrium through down-regulation of actRIIB and BMP7. Thus, we propose that BMP7 and actRIIB, a ligand-receptor pair, are involved in regulation of the apoptotic signaling pathway and might therefore be new biomarkers of the effects of environmental estrogens on the female reproductive tract. 相似文献
132.
Cilostazol enhances IL-1beta-induced NO production and apoptosis in rat vascular smooth muscle via PKA-dependent pathway 总被引:1,自引:0,他引:1
Ito C Kusano E Akimoto T Takeda S Sasaki N Umino T Iimura O Ando Y Asano Y 《Cellular signalling》2002,14(7):625-632
Interleukin-1beta (IL-1beta) stimulates nitric oxide (NO) production and induces apoptosis in several tissues. Cilostazol is a Type 3 phosphodiesterase inhibitor. We investigated whether cilostazol affects IL-1beta-induced NO production and apoptosis in rat vascular smooth muscle cells. Cilostazol (100 nM-10 microM) potentiated NO production triggered by IL-1beta. The mRNA and protein expression of inducible NO synthase was also upregulated by cilostazol. KT5720, an inhibitor of protein kinase A, and N(G)-monomethyl-L-arginine, an inhibitor of NO synthase, abrogated cilostazol-enhanced IL-1beta-stimulated NO production and apoptosis. These results shows that cilostazol potentiates IL-1beta-induced NO production via PKA-pathway and thereafter augments apoptosis via NO-dependent pathway. 相似文献
133.
Sugimori M Kiribuchi K Akimoto C Yamaguchi T Minami E Shibuya N Sobajima H Cho EM Kobashi N Nojiri H Omori T Nishiyama M Yamane H 《Bioscience, biotechnology, and biochemistry》2002,66(5):1140-1142
Two cDNA clones for jasmonic acid (JA)-responsive genes, RRJ1 and RRJ2, were isolated by differential screening from suspension-cultured rice cells treated with JA for 2 h. The putative RRJ1 protein is completely identical to that of a putative rice cystathionine gamma-lyase, while the putative RRJ2 protein is highly similar in sequence to a rice pyruvate decarboxylase, PDC1. 相似文献
134.
Ota F Yamato M Hayashi M Ota M Koga T Sherin A Mukai C Sakai K Yamamoto S 《Microbiological research》2002,157(4):305-310
Twenty four reference strains (serotype a-h) belonging to the mutans group of streptococci were compared for DNA fragment patterns of rDNA after treatment with Hind III. It was shown that Streptococcus cricetus (serotype a), S. rattus (serotype b), and S. downei (serotype h) reveals comparatively homogeneous patterns while S. mutans (serotype c, e and f) exhibits differences between the different serotypes as well as within single serotypes. S. sobrinus had an intermediary diversity. These data support the previous findings that S. mutans is heterogeneous at the serological, biochemical and genetical level. 相似文献
135.
José C. Sánchez-Ferrer Jorge Servín Jairo Muñoz-Delgado Chiharu Murata Ignacio Méndez Ramírenz Jesús Sánchez-Robles 《Biological Rhythm Research》2016,47(4):539-551
It is assumed that the response of the regulatory system of mammal activity depends on the changes in light intensity throughout the 24-h cycle. The aim of this study was to determine whether the moon luminosity cycle exerts an effect on the locomotor activity of the Mexican wolf (C. lupus baileyi). Data collection was carried out with the actimetry, of 11 individuals were analyzed using ANOVA to determine the effect of the lunar cycle. Significant differences were encountered between moon phases (p = 0.001), with a decrement of activity during new and full moon. However, effects were dependent also on the age of the individuals and the daylight period. On the other hand, it is a possible regulation of the activity pattern by the effect of lunar periodicity. This periodicity needs a more detailed examination to determine its adaptive function. 相似文献
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Chiharu Sadakane Shuichi Muto Koji Nakagawa Shunsuke Ohnishi Yayoi Saegusa Miwa Nahata Tomohisa Hattori Masahiro Asaka Hiroshi Takeda 《Biochemical and biophysical research communications》2011,(3):506
Rikkunshito (RKT), a Japanese traditional medicine, has been shown to stimulate food intake in rats with cisplatin-induced anorexia; however, the underlying mechanisms remain unknown. In this study, we investigated whether RKT is involved in the degradation of peripheral ghrelin. RKT inhibited decreases in plasma ghrelin level and enhanced acyl- to desacyl-ghrelin (A/D) ratio in cisplatin-treated rats. Several components of RKT demonstrated inhibitory activity against ghrelin deacylating enzymes. In addition, 10-gingerol, a component of RKT, inhibited exogenous ghrelin deacylation. Therefore, RKT may enhance plasma acyl-ghrelin level, at least in part, by inhibiting the circulating ghrelin degrading enzyme. 相似文献
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140.
Tomoko Fuke Seiji Mizuno Toshiro Nagai Tomonobu Hasegawa Reiko Horikawa Yoko Miyoshi Koji Muroya Tatsuro Kondoh Chikahiko Numakura Seiji Sato Kazuhiko Nakabayashi Chiharu Tayama Kenichiro Hata Shinichiro Sano Keiko Matsubara Masayo Kagami Kazuki Yamazawa Tsutomu Ogata 《PloS one》2013,8(3)