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971.
Chiara Sinigaglia Henriette Busengdal Lucas Leclère Ulrich Technau Fabian Rentzsch 《PLoS biology》2013,11(2)
The origin of the bilaterian head is a fundamental question for the evolution of animal body plans. The head of bilaterians develops at the anterior end of their primary body axis and is the site where the brain is located. Cnidarians, the sister group to bilaterians, lack brain-like structures and it is not clear whether the oral, the aboral, or none of the ends of the cnidarian primary body axis corresponds to the anterior domain of bilaterians. In order to understand the evolutionary origin of head development, we analysed the function of conserved genetic regulators of bilaterian anterior development in the sea anemone Nematostella vectensis. We show that orthologs of the bilaterian anterior developmental genes six3/6, foxQ2, and irx have dynamic expression patterns in the aboral region of Nematostella. Functional analyses reveal that NvSix3/6 acts upstream of NvFoxQ2a as a key regulator of the development of a broad aboral territory in Nematostella. NvSix3/6 initiates an autoregulatory feedback loop involving positive and negative regulators of FGF signalling, which subsequently results in the downregulation of NvSix3/6 and NvFoxQ2a in a small domain at the aboral pole, from which the apical organ develops. We show that signalling by NvFGFa1 is specifically required for the development of the apical organ, whereas NvSix3/6 has an earlier and broader function in the specification of the aboral territory. Our functional and gene expression data suggest that the head-forming region of bilaterians is derived from the aboral domain of the cnidarian-bilaterian ancestor. 相似文献
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976.
Bergallo Massimiliano Canosa Stefano Galliano Ilaria Daprà Valentina Montanari Paola Sestero Marta Gennarelli Gianluca Benedetto Chiara Revelli Alberto Tovo Pier-Angelo 《Molecular biology reports》2021,48(7):5803-5808
Molecular Biology Reports - Human endogenous retroviruses (HERVs), remnants of ancestral infections, represent 8% of the human genome. HERVs are co-opted for important physiological functions... 相似文献
977.
Matteo Burigotto Alessia Mattivi Daniele Migliorati Giovanni Magnani Chiara Valentini Michela Roccuzzo Martin Offterdinger Massimo Pizzato Alexander Schmidt Andreas Villunger Stefano Maffini Luca L Fava 《The EMBO journal》2021,40(4)
Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase‐2), whose activation results in cleavage of p53’s key inhibitor, MDM2. Here, we demonstrate that PIDD1 is recruited to mature centrosomes by the centriolar distal appendage protein ANKRD26. PIDDosome‐dependent Caspase‐2 activation requires not only PIDD1 centrosomal localization, but also its autoproteolysis. Following cytokinesis failure, supernumerary centrosomes form clusters, which appear to be necessary for PIDDosome activation. In addition, in the context of DNA damage, activation of the complex results from a p53‐dependent elevation of PIDD1 levels independently of centrosome amplification. We propose that PIDDosome activation can in both cases be promoted by an ANKRD26‐dependent local increase in PIDD1 concentration close to the centrosome. Collectively, these findings provide a paradigm for how centrosomes can contribute to cell fate determination by igniting a signalling cascade. 相似文献
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Brooke Sadler Jackson Wilborn Lilian Antunes Timothy Kuensting Andrew T. Hale Stephen R. Gannon Kevin McCall Carlos Cruchaga Matthew Harms Norine Voisin Alexandre Reymond Gerarda Cappuccio Nicola Brunetti-Pierri Marco Tartaglia Marcello Niceta Chiara Leoni Giuseppe Zampino Allison Ashley-Koch Gabe Haller 《American journal of human genetics》2021,108(3):530-531
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Weber Igor Daniel Lopes Welinton Ribamar de Paula Letícia Chiara Baldassio Albernaz-Godinho Karina Cordeiro Czepak Cecilia 《BioControl》2021,66(5):625-637
BioControl - Lepidopterans are among the most important groups of pests for crops in central Brazil. Fortunately, there is a significant diversity of natural enemies acting in the natural... 相似文献