全文获取类型
收费全文 | 221篇 |
免费 | 8篇 |
国内免费 | 1篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2019年 | 2篇 |
2018年 | 4篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 8篇 |
2014年 | 9篇 |
2013年 | 6篇 |
2012年 | 14篇 |
2011年 | 12篇 |
2010年 | 9篇 |
2009年 | 11篇 |
2008年 | 9篇 |
2007年 | 3篇 |
2006年 | 9篇 |
2005年 | 10篇 |
2004年 | 2篇 |
2003年 | 12篇 |
2002年 | 2篇 |
2001年 | 4篇 |
2000年 | 7篇 |
1999年 | 4篇 |
1998年 | 9篇 |
1997年 | 2篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1992年 | 7篇 |
1991年 | 4篇 |
1989年 | 9篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 5篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1966年 | 2篇 |
1965年 | 1篇 |
排序方式: 共有230条查询结果,搜索用时 31 毫秒
11.
Gong Chang Cheng Ziliang Yang Yaping Shen Jun Zhu Yingying Ling Li Lin Wanyi Yu Zhigang Li Zhihua Tan Weige Zheng Chushan Zheng Wenbo Zhong Jiajie Zhang Xiang Zeng Yunjie Liu Qiang Huang R. Stephanie Komorowski Andrzej L. Yang Eddy S. Bertucci François Ricci Francesco Orlandi Armando Franceschini Gianluca Takabe Kazuaki Klimberg Suzanne Ishii Naohiro Toss Angela Tan Mona P. Cherian Mathew A. Song Erwei 《中国科学:生命科学英文版》2022,65(11):2205-2217
Science China Life Sciences - Patients with hormone receptor (HR)-positive tumors breast cancer usually experience a relatively low pathological complete response (pCR) to neoadjuvant chemotherapy... 相似文献
12.
Vijai J Kapoor A Ravishankar HM Cherian PJ Girija AS Rajendran B Rangan G Jayalakshmi S Mohandas S Radhakrishnan K Anand A 《Human genetics》2003,113(5):461-463
Juvenile myoclonic epilepsy (JME) is a common subtype of idiopathic generalized epilepsy that shows a complex pattern of inheritance. We have tested the association between JME phenotype and an intragenic marker in KCNQ3 by using the transmission disequilibrium test in 119 probands and their parents. Mutations in KCNQ3 are known to cause benign familial neonatal convulsions and are involved in the physiologically important M current in neurons. Our results provide suggestive evidence of allelic association between JME and KCNQ3 (P-value=0.008) and raise an interesting possibility of a genetic contribution to JME, viz., of a gene that causes a monogenic form of human epilepsy. 相似文献
13.
Metallothioneins in human tumors and potential roles in carcinogenesis 总被引:19,自引:0,他引:19
14.
High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism 总被引:6,自引:0,他引:6
Apostolova MD Chen S Chakrabarti S Cherian MG 《American journal of physiology. Cell physiology》2001,281(3):C899-C907
Vascular endothelial cells areconstantly exposed to oxidative stress and must be protected byphysiological responses. In diabetes mellitus, endothelial cellpermeability is impaired and may be increased by high extracellularglucose concentrations. It has been postulated that metallothionein(MT) can protect endothelial cells from oxidative stress with itsincreased expression by cytokines, thrombin, and endothelin (ET)-1. Inthis study, we demonstrate that high glucose concentration can induceMT expression in endothelial cells through a distinct ET-dependentpathway. Exposure of human umbilical vein endothelial cells (HUVEC) toincreasing concentrations of glucose resulted in a rapid dose-dependentincrease in MT-2 and ET-1 mRNA expression. MT expression may be furtheraugmented with addition of ET-1. Preincubation of the cells with thespecific ETB antagonist BQ-788 blocked MT-2 mRNA expressionmore effectively than the ETA inhibitor TBC-11251. Highglucose also increased immunoreactive MT protein expression and inducedtranslocation of MT into the perinuclear area. Perinuclear localizationof MT was related to high-glucose-induced reorganization of F-actin filaments. These results demonstrate that an increase in extracellular glucose in HUVEC can lead to a rapid dose-dependent increase in MT-2mRNA expression and to perinuclear localization of MT protein withchanges to the cytoskeleton. These effects are mediated via the ETreceptor-dependent pathway. 相似文献
15.
Phylogenetic relationships were determined for 76 partial P-element
sequences from 14 species of the melanogaster species group within the
Drosophila subgenus Sophophora. These results are examined in the context
of the phylogeny of the species from which the sequences were isolated.
Sequences from the P-element family fall into distinct subfamilies, or
clades, which are often characteristic for particular species subgroups.
When examined locally among closely related species, the evolution of P
elements is characterized by vertical transmission, whereby the P-element
phylogeny traces the species phylogeny. On a broader scale, however, the
P-element phylogeny is not congruent with the species phylogeny. One
feature of P-element evolution in the melanogaster group is the presence of
more than one P-element subfamily, differing by as much as 36%, in the
genomes of some species. Thus, P elements from several individual species
are not monophyletic, and a likely explanation for the incongruence between
P-element and species phylogenies is provided by the comparison of
paralogous sequences. In certain instances, horizontal transfer seems to be
a valid alternative explanation for lack of congruence between species and
P-element phylogenies. The canonical P-element subfamily, which represents
the active, autonomous transposable element, is restricted to D.
melanogaster. Thus, its origin clearly lies outside of the melanogaster
species group, consistent with the earlier conclusion of recent horizontal
transfer.
相似文献
16.
The developmental alterations in metallothionein (MT) proteins and zinc (Zn) were investigated in brains of two transgenic
strains of mice. MT protein was measured by a cadmium binding assay and Zn by atomic absorption spectrophotometry. MT proteins
were expressed at birth (day 1) both in MT-I overexpressing transgenic mouse (MT-I*) and MT-null (expressing only brain specific
isoform, MT-III) transgenic mouse. MT proteins level (mainly MT-I) in MT-I* was 16.1 Μ-g/g at birth, and thereafter increased
with age to a maximal adult level of 55.3 Μg/g (day 60). Zn level in MT-I* also increased from 8.43 Μg/g (day 1) to 20.7 Μg/g
(day 60) with age. MT protein (MT-III) in MT-null mouse was 9.71 Μg/g at birth and remained relatively unchanged during development.
Zn level in MT-null mouse at birth was 9.46 Μg/g and also remained unchanged during development. The similar alterations in
MT isoforms and Zn in brain during development suggest that MT isoforms may act as a Zn binding protein. 相似文献
17.
Jose MG Vilar 《BMC systems biology》2010,4(1):152
Background
Cellular responses to death-promoting stimuli typically proceed through a differentiated multistage process, involving a lag phase, extensive death, and potential adaptation. Deregulation of this chain of events is at the root of many diseases. Improper adaptation is particularly important because it allows cell sub-populations to survive even in the continuous presence of death conditions, which results, among others, in the eventual failure of many targeted anticancer therapies. 相似文献18.
19.
The emergence of new strains of Influenza virus have caused several pandemics over the last hundred years with the latest being the H1N1 Swine flu pandemic of 2009. The Hemagglutinin (HA) protein of the Influenza virus is the primary target of human immune system and is responsible for generation of protective antibodies in humans. Mutations in this protein results in change in antigenic regions (antigenic drift) which consequently leads to loss of immunity in hosts even in vaccinated population (herd immunity). This necessitates periodic changes in the Influenza vaccine composition. In this paper, we investigate the molecular basis of the reported loss of herd immunity in vaccinated population (vaccine component: Influenza A/X-31/1968 (H3N2)) which resulted in the outbreak due to strain Influenza A/Port Chalmers/1/1973 (H3N2). Also, the effects of antigenic drift in HA protein (H3N2 vaccine strains 1968-2007) on the 3D structures as well as interactions with BH151, a 1968 antibody, has been studied. Rigid body molecular docking protocol has been used to study the antigen-antibody interactions. We believe that the present study will help in better understanding of host-pathogen interactions at the molecular level. 相似文献
20.