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981.
Alkaline sucrose solution was demonstrated to be a good solvent for the solubilization of water-insoluble drugs. At high concentration
and alkaline pH, sucrose solubilizes water-insoluble molecules through intramolecular conformations. Tetracyline and chloramphenicol,
when dissolved in alkaline sucrose solution, retained their bactericidal activity. Gel permeation-chromatography analysis
and atomic-force-microscopy studies confirmed the formation of sucrose-antibiotics complex. 相似文献
982.
Summary The gene specifying cytosine deaminase (cod) is shown to be located at approximately 86 minutes on the linkage map of E. coli. The corresponding gene in S. typhimurium has been reported to have a different location. 相似文献
983.
A V Martynikhin I V Poliakov A A Timofeev E V Rubakhina 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1985,35(2):232-237
The influence of spatio-temporal factors (spatial heterogeneity of distribution of the numbers sought for in the matrix of data, processes of learning and development of fatigue, periodic attention oscillations) of the character of solving the task of searching the numbers in a matrix of 176 three-figure numbers (16 lines, 11 columns) was studied in 39 operators. The possibility was shown to use the characteristics obtained for evaluation of professionally important abilities of an operator working at the display. 相似文献
984.
Michitaro Nagasawa James Amigo Chan Charles J. Sih 《Prostaglandins & other lipid mediators》1974,8(3):221-230
Prostaglandins E1, F1α and A2 were covalently joined to the surface of Sepharose as carboxamide linkages. The insolubilized prostaglandins were shown to function effectively in the purification of 15(S) -hydroxyprostaglandin dehydrogenase. 相似文献
985.
986.
I M Badalova B N Mishan'kin I Iu Suchkov 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1987,(5):24-28
In two different strains of cholera vibrios two recA-dependent plasmids, pVib I (1.9-2.2 Md) and pVib II (5.2-5.8 Md), have been detected. These plasmids determine the synthesis of vibriocin, coagulase and fibrinolysin, which has been established by the cotransformation of the DNA of plasmids pVib I and pBR322 and by the transfer mobilization with the use of plasmid RP4. 相似文献
987.
988.
989.
The steady-state kinetics of Pseudomonas aeruginosa cytochrome oxidase were studied. Reduced cytochrome c551 and azurin from the same bacteria were used as the electron-donating substrates, while dioxygen served as the electron acceptor. Oxidized cytochrome c551 and azurin exhibited product inhibition of the reaction. However, apo-azurin and azurin derivatives in which the copper was substituted by the redox-inert ions Ni2+, Co2+, Cd2+ and Zn2+, did not show any effect on the kinetics. These observations implied that complex formation between the substrates or the products and the enzyme is not a rate-limiting step and is not the cause for product inhibition. The integrated rate law for a reaction scheme in which we assumed that complex formation was not rate limiting was fitted to the complete reaction traces. The results suggested that it is the low thermodynamic driving force, expressed in the small differences in redox potential between the substrates and heme c of the enzyme, which cause the observed product inhibition. 相似文献
990.