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41.
William W. Lockwood Raj Chari Bradley P. Coe Kelsie L. Thu Cathie Garnis Chad A. Malloff Jennifer Campbell Ariane C. Williams Dorothy Hwang Chang-Qi Zhu Timon P. H. Buys John Yee John C. English Calum MacAulay Ming-Sound Tsao Adi F. Gazdar John D. Minna Stephen Lam Wan L. Lam 《PLoS medicine》2010,7(7)
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Thomas Mailund Gerth S Brodal Rolf Fagerberg Christian NS Pedersen Derek Phillips 《BMC bioinformatics》2006,7(1):29-8
Background
The neighbor-joining method by Saitou and Nei is a widely used method for constructing phylogenetic trees. The formulation of the method gives rise to a canonical Θ(n 3) algorithm upon which all existing implementations are based. 相似文献45.
Spurgers KB Chari NS Bohnenstiehl NL McDonnell TJ 《Cell death and differentiation》2006,13(8):1360-1370
A consistent, if not invariant, feature of cancer cells is the acquired ability to evade apoptosis. The pioneering work of Dr. Stan Korsmeyer was invaluable in characterizing the molecular foundations of cell death signaling mechanisms during normal development and during multistep carcinogenesis. This foundation now forms the basis for the rational design of therapeutic strategies to selectively activate cell death in cancer cell populations. These strategies are currently being evaluated in an increasing number of clinical trials targeting diverse tumor types. 相似文献
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Root C Smith CD Sundseth SS Pink HM Wilson JG Lewis MC 《Journal of lipid research》2002,43(8):1320-1330
264W94 was designed to inhibit the ileal bile acid transporter (IBAT). Evaluated in vitro, 264W94 dose-dependently inhibited sodium-dependent uptake of 10 micro M [(3)H]taurocholic acid (TC) by rat and monkey brush border membrane vesicles with IC(50)s of 0.24 micro M and 0.41 micro M, and had a competitive profile with K(i) of 0.2 micro M against TC in Chinese hamster ovary cells expressing human IBAT. In distal ileum in situ, 1-10 micro M of 264W94 rapidly decreased uptake of 3mM TC by 24-39%, with corresponding decreases in biliary recovery. In rats and mice in vivo, oral 264W94 decreased absorption of TC analog, 23,25-(75)Se-homocholic acid taurine ((75)SeHCAT; quantitated in feces), with ED(30) of 0.02 mg/kg bid. (75)SeHCAT traced through the GI-tract revealed that peak (97%) inhibition of (75)SeHCAT absorption by the distal quarter of small intestine occurred at 4 h after single dose of 264W94 (0.1 mg/kg). Inhibition of IBAT by 264W94 in rats was associated with compensatory, same-day, 4-fold induction of hepatic cholesterol 7alpha-hydroxylase (CYP7A1) activity, exhibiting normal diurnal fluctuation for 3 days of dosing. In diet induced hypercholesterolemic rats, 264W94 (0.03-1.0 mg/kg bid) dose-dependently reduced serum LDL+VLDL cholesterol up to 61%. In conclusion, 264W94 is a potent new cholesterol lowering agent that acts through inhibition of IBAT and exhibits activity in a human model. 相似文献
48.
We have constructed a series of vectors based on simian foamy virus type 1 (SFV-1) to define the minimum cis-acting elements required for gene transfer. To characterize these vectors, we inserted the coding sequence of the bacterial lacZ gene linked to the cytomegalovirus immediate-early gene promoter. Introduction of a deletion mutation in the leader region between the 5′ long terminal repeat and the start of the gag gene at position 1659 to 1694 completely abrogated gene transfer by the SFV-1 vector. Deletion of 39 nucleotides from position 1692 to 1731 in the leader region resulted in a significant reduction in the transducing-particle titer. Furthermore, we have identified a second cis-acting element located at the 3′ end of the pol gene between position 6486 and 6975 to be critical for SFV-1 vector transduction. These results identify the two important cis-acting elements required for SFV-1 vector construction, and the finding of a cis-acting element in the pol gene is unique among retroviruses. 相似文献
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Synthesis of (+)-11-hydroxyhexadecanoic acid-O-(4-O-α-L-rhamnopyranosyl)-α-L- rhamnopyranoside showed that muricatin B from Ipomoea muricata does not contain the proposed β- but an α-linked dirhamnoside moiety. This is the first reported synthesis of a naturally occurring O-glycoside of a long chain hydroxy-fatty acid. 相似文献
50.
Baloglu E Miller ML Roller EE Cavanagh EE Leece BA Goldmacher VS Chari RV 《Bioorganic & medicinal chemistry letters》2004,14(23):5885-5888
The use of drug-antibody conjugates affords a method for the targeted delivery of anticancer drugs specifically to cancer cells. Monoclonal antibodies alone usually do not possess high therapeutic efficacy, however, they are capable of targeting tumor markers selectively. We have prepared taxoids with significantly higher cytotoxicity than paclitaxel and docetaxel. These taxoids now meet the high potency required for use in a targeted-delivery approach using monoclonal antibodies. The synthesis and biological evaluation of these taxoids are reported. 相似文献