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Variations in the diet of introduced Norway rats (Rattus norvegicus) inferred using stable isotope analysis 总被引:2,自引:0,他引:2
The presence of introduced Norway rats Rattus norvegicus has raised concerns for the fate of the large least auklet Aethia pusilla colony situated at Sirius Point, Kiska Island, Alaska. Previous studies have documented extreme interannual variation in least auklet reproductive success and potential drastic population declines, both of which have been attributed to the varying abundance of, and predation by, Norway rats. A diet study would resolve the uncertainty that remains about the role of rats in the auklet's reproductive failure and the colony's decline. Our main objectives here were to quantify the variation in diet of introduced Norway rats and assess predation on least auklets. Using stable isotope analysis we document wide variability in rat diet dependent on location and provide direct evidence that Norway rats are preferentially preying on least auklets at Sirius Point. In conclusion, we hypothesize that the observed wide variability in rat diet will contribute to the persistence of rats on Kiska long after auklets have been extirpated. The persistence of rats enabled by their foraging plasticity will increase their effects by creating ecological traps within which prospecting individuals will fall and be depredated. This has large conservation consequences as it suggests that when seabirds are extirpated recolonization by prospecting birds is virtually impossible and island ecosystems will continue to be negatively affected and altered as long as introduced predators, such as rats, remain within them. 相似文献
383.
Kerstin Bellmann Steve J. Charette Philippe J. Nadeau Dominic J. Poirier Anne Loranger Jacques Landry 《Cell stress & chaperones》2010,15(1):101-113
The cellular response to heat shock (HS) is a paradigm for many human diseases collectively known as “protein conformation
diseases” in which the accumulation of misfolded proteins induces cell death. Here, we analyzed how cells having a different
apoptotic threshold die subsequent to a treatment with HS. Cells with a low apoptotic threshold mainly induced apoptosis through
activation of conventional stress kinase signaling pathways. By contrast, cells with a high apoptotic threshold also died
by apoptosis but likely after the accumulation of heat-aggregated proteins as revealed by the formation of aggresomes in these
cells, which were associated with the generation of atypical nuclear deformations. Inhibition of the proteasome or expression
of an aggregation prone protein produced similar nuclear alterations. Furthermore, elevated levels of chaperones markedly
suppressed both HS-induced nuclear deformations and apoptosis induced upon protein aggregation whereas they had little effect
on stress kinase-mediated apoptosis. We conclude that the relative contribution of stress signaling pathways and the accumulation
of protein aggregates to cell death by apoptosis is related to the innate sensitivity of cells to deadly insults. 相似文献
384.
The gene product of the pleiotropic lon (also called capR) locus in Escherichia coli, the CapR protein, is an ATP hydrolysis-dependent protease and a nonspecific nucleic acid-binding protein. We demonstrated that it is also a DNA-stimulated adenosine triphosphatase (ATPase). This new activity is distinct from the protease-associated ATPase activity and occurs in the absence of proteolytic substrate. The reaction requires the presence of a divalent cation and has a pH optimum of 8.0. The products of the reaction are ADP and inorganic phosphate. No adenylation or phosphorylation of the DNA or proteins was detected. The maximum rate of ATP hydrolysis occurs in the presence of supercoiled (form I) DNA. Relaxed circles (form II), double-stranded DNA, and single-stranded DNA are less effective in promoting ATPase activity, whereas RNA is inactive. The DNA-stimulated ATPase activity is inhibited by a mutationally altered form of the CapR protein called the CapR9 protein. The interaction of the CapR and CapR9 subunits suggests that this enzymatic activity of the CapR protein is oligomeric in the presence of DNA. Our in vitro experiments indicate a possible role for nucleic acids in the regulation of all lon (capR) activity. 相似文献
385.
Cédric Blanc Steve J. Charette Sara Mattei Laurence Aubry Ewan W. Smith Pierre Cosson François Letourneur 《Traffic (Copenhagen, Denmark)》2009,10(2):161-171
Sorting of ubiquitinated proteins to multivesicular bodies (MVBs) in mammalian cells relies on proteins with a Vps27/Hrs/STAM (VHS) domain. Here, we show that the amoeba Dictyostelium presents only one protein with a VHS domain: DdTom1. We demonstrate that the VHS domain of DdTom1 is followed by a Golgi-localized, γ-ear-containing, ADP-ribosylation-factor-binding and Tom1 (GAT) domain that binds ubiquitin, and by a non-conserved C-terminal domain that can recruit clathrin, EGFr pathway substrate 15 and tumor susceptibility gene 101, a component of the MVB biogenesis machinery [endosomal complexes required for transport (ESCRT) complexes]. Both VHS and GAT domains interact with phospholipids and therefore could ensure the recruitment of DdTom1 to endosomal membranes. We propose that DdTom1 participates in an ancestral ESCRT-0 complex implicated in the sorting of ubiquitinated proteins into MVBs. 相似文献
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