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Zhu Kai Guo Song Han Guoyi Qiang Xiancheng Ma Mengmeng Xu Qinglei Tang Wenjie Tan Jun 《Molecular biology reports》2022,49(5):3783-3792
Molecular Biology Reports - Oxidative stress in the intervertebral disc leads to nucleus pulposus (NP) degeneration by inducing cell apoptosis. However, the molecular mechanisms underlying this... 相似文献
997.
Plant and Soil - To assess the direction and strength of climate and leaf litter trait effects on decomposition dynamics throughout the litter decomposition process. We performed a three-year-long... 相似文献
998.
Gilbert JR Kumar A Newey S Rao N Ioannou P Qiu H Lin D Xu P Pettenati MJ Pericak-Vance MA 《Human heredity》2000,50(3):151-157
Chromosome 9q34 has been extensively studied and mapped due to the presence of known disease genes, principally tuberous sclerosis 1 (TSC1), in this region. During the course of our mapping of this region we constructed a 555-kb contig beginning approximately 50 kb proximal to the dopamine-beta-hydroxylase (DBH) gene and extending, with one small deletion, distal to the D9S114 marker. The contig consists of 11 P1 clones, four PAC clones, one BAC clone and six cosmid clones and contains 27 new nonpolymorphic STSs. We have found the region to be unstable in P1, PAC and BAC cloning vehicles and have identified several deleted genomic clones. In addition, we have isolated and mapped the 3' portions of three putative genes located within or immediately distal to the DBH gene, including one large gene that runs on the opposite strand to DBH and utilizes portions of two DBH exons. The genomic clones of the contig, cDNAs and new STSs will be useful reagents for the further study and mapping of this region. 相似文献
999.
Xu M Nakai N Ishigure K Nonami T Nagasaki M Obayashi M Li Z Sato Y Fujitsuka N Murakami T Shimomura Y 《Biochemical and biophysical research communications》2000,276(3):1080-1084
Catabolism of alpha-ketoisocaproate in liver is mediated by cytosolic alpha-ketoisocaproate dioxygenase (KICD) and mitochondrial branched-chain alpha-keto acid dehydrogenase complex (BCKDC). The latter is believed to be involved in the main pathway of the KIC catabolism. In the present study, we measured the activities of KICD and BCKDC in human and rat livers. The KICD activity in human liver was 0.9 mU/g tissue, which was 14.2% of the total activity of BCKDC, and that in rat liver was 4.2 mU/g tissue, which was only 1.0% of the total activity, suggesting that KICD in human liver plays a relatively important role in the alpha-ketoisocaproate catabolism. The KICD activity in human liver was significantly increased by cirrhosis. In rat liver, the enzyme activity was markedly increased by physical training and streptozotocin-induced diabetes, but not by feeding of a diet rich in branched-chain amino acids, although BCKDC activity was increased by feeding of the diet. 相似文献
1000.
Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China
Jianfang Zhou Chuanyun Qian Mingyan Zhao Xiangyou Yu Yan Kang Xiaochun Ma Yuhang Ai Yuan Xu Dexin Liu Youzhong An Dawei Wu Renhua Sun Shusheng Li Zhenjie Hu Xiangyuan Cao Fachun Zhou Li Jiang Jiandong Lin Enqiang Mao Tiehe Qin Zhenyang He Lihua Zhou Bin Du for the China Critical Care Clinical Trials Group 《PloS one》2014,9(9)