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591.
Understanding how behavioral diversity arises and is maintained is central to evolutionary biology. Genetically based inheritance has been a predominant research focus of the last century; however, nongenetic inheritance, such as social transmission, has become a topic of increasing interest [1]. How social information impacts behavior depends on the balance between information gathered directly through personal experience versus that gleaned through social interactions and on the diffusion of this information within groups [2, 3]. We investigate how female Drosophila melanogaster use social information under seminatural conditions and whether this information can spread and be maintained within a group, a prerequisite for establishing behavioral transmission [4]. We show that oviposition site choice is heavily influenced by previous social interactions. Naive observer flies develop a preference for the same egg-laying medium as experienced demonstrator flies conditioned to avoid one of two equally rewarding media. Surprisingly, oviposition site preference was socially transmitted from demonstrators to observers even when they interacted in a cage with only unflavored, pure agar medium, and even when the observer flies had previous personal experience with both rewarding media. Our findings shed light on the diffusion process of social information within groups, on its maintenance, and ultimately, on the roots of behavioral local adaptation. 相似文献
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593.
Insertion of bacterial insertion sequence IS911 can often be directed to sequences resembling its ends. We have investigated this type of transposition and shown that it can occur via cleavage of a single end and its targeted transfer next to another end. The single end transfer (SET) events generate branched DNA molecules that contain a nicked Holliday junction and can be considered as partial transposition products. Our results indicate that these can be processed by the Escherichia coli host independently of IS911-encoded proteins. Such resolution depends on the presence of homologous DNA regions neighbouring the cross-over point in the SET molecule. Processing is often accompanied by sequence conversion between donor and target sequences, suggesting that branch migration is involved. We show that resolution is greatly reduced in a recG host. Thus, the branched DNA-specific helicase, RecG, involved in processing of potentially lethal DNA structures such as stalled replication forks, also intervenes in the resolution of partial IS911 transposition products. 相似文献
594.
Genevieve Paulissen Natacha Rocks Maud M Gueders Celine Crahay Florence Quesada-Calvo Sandrine Bekaert Jonathan Hacha Mehdi El Hour Jean-Michel Foidart Agnes Noel Didier D Cataldo 《Respiratory research》2009,10(1):127
Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And Metalloproteinases (ADAMs) and ADAMs with Thrombospondin motifs (ADAMTS) are proteinases closely related to Matrix Metalloproteinases (MMPs). These multifaceted molecules bear metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion molecules. Proteinases of the ADAM family are associated to various physiological and pathological processes and display a wide spectrum of biological effects encompassing cell fusion, cell adhesion, "shedding process", cleavage of various substrates from the extracellular matrix, growth factors or cytokines... This review will focus on the putative roles of ADAM/ADAMTS proteinases in airway diseases such as asthma and COPD. 相似文献
595.
Johan Elmberg Celine Arzel Gunnar Gunnarsson Sari Holopainen Petri Nummi Hannu Pöysä Kjell Sjöberg 《Freshwater Biology》2020,65(2):167-177
- Understanding drivers of variation and trends in biodiversity change is a general scientific challenge, but also crucial for conservation and management. Previous research shows that patterns of increase and decrease are not always consistent at different spatial scales, calling for approaches combining the latter. We here explore the idea that functional traits of species may help explaining divergent population trends.
- Complementing a previous community level study, we here analyse data about breeding waterbirds on 58 wetlands in boreal Fennoscandia, covering gradients in latitude as well as trophic status. We used linear mixed models to address how change in local abundance over 25 years in 25 waterbird species are associated with life history traits, diet, distribution, breeding phenology, and habitat affinity.
- Mean abundance increased in 10 species from 1990/1991 to 2016, whereas it decreased in 15 species. Local population increases were associated with species that are early breeders and have small clutches, an affinity for luxurious wetlands, an herbivorous diet, and a wide breeding range rather than a southern distribution. Local decreases, by contrast, were associated with species having large clutches and invertivorous diet, as well as being late breeders and less confined to luxurious wetlands. The three species occurring on the highest number of wetlands all decreased in mean abundance.
- The fact that early breeders have done better than late fits well with previous research about adaptability to climate change, that is, response to earlier springs. We found only limited support for the idea that life history traits are good predictors of wetland level population change. Instead, diet turned out to be a strong candidate for an important driver of population change, as supported by a general decrease of invertivores and a concomitant increase of large herbivores.
- In a wider perspective, future research needs to address whether population growth of large-bodied aquatic herbivores affects abundance of co-occurring invertivorous species, and if so, if this is due to habitat alteration, or to interference or exploitative competition.
596.
Transport of L-glutamine into rat cortical synaptosomes has been investigated by (14C)L-glutamine uptake experiments. This amino acid enters synaptosomes both by an active carrier mediated system, which may be the result of gamma-glutamyl cycle activity and by a Na+-dependent transport system. This view is supported by the following observations: a) as demonstrated previously (10), glutamine inside synaptosomes reaches concentrations higher than those of the incubation medium, and initial rates of uptake approach saturation kinetics; b) the uptake of glutamine is inhibited by uncouplers; c) the uptake is inhibited by methionine sulfoximine, a suicide-inhibitor of an enzyme of the gamma-glutamyl cycle; d) the initial rate of uptake is lowered by decreasing the Na+-level of the incubation medium or by adding ouabain. The validity of this hypothesis is discussed. 相似文献
597.
In Alzheimer and Parkinson’s disease cell death of cholinergic and dopaminergic neurons are characteristic hallmarks, respectively.
It is well established that rotenone, an inhibitor of complex I of the electron transport chain, induces cell death of dopaminergic
neurons, however, not much is known on the effects of rotenone on cholinergic neurons. The aim of the present study was to
evaluate the effects of rotenone on cholinergic neurons in an organotypic in vitro brain co-slice model. When co-cultures
were treated with 10 μM rotenone for 24 h a significantly decreased number of cholinergic neurons was found in the basal nucleus
of Meynert but not in the dorsal striatum. This cell death exhibited apoptotic DAPI-positive malformed nuclei and enhanced
TUNEL-positive cells. In summary, inhibition of complex I of the electron transport chain may play a role in neurodegeneration
of cholinergic neurons. 相似文献
598.
Celine Santiago Bass Suruchi Bhan Graeme M. Smith Judith S. Weis 《Hydrobiologia》2001,450(1-3):231-241
Mature Palaemonetes pugio, from a polluted estuary, Piles Creek (PC) are larger than those in a more pristine estuary in Tuckerton (TK). Possible causes for the differences in size-structure could be differences in environmental factors at the two creeks, differential competition at the two sites, inherent factors causing a greater growth rate in the PC population, differences in reproductive timing, or differential predation at the two sites. Lab microcosm studies were used to examine the possibility of inherent population differences or environmental conditions (including differences in salinity) causing faster growth in PC. There was no evidence that PC shrimp grew faster than TK shrimp, nor that PC conditions fostered greater growth compared to TK. Salinity adjustments in PC and TK tanks also had no effect on growth. Therefore, it appears that genetic and environmental factors did not play a significant role in greater shrimp growth in PC. In the field, data on relative abundances of Fundulus heteroclitus and P. pugio, and size-frequency distributions of P. pugio were collected from the two estuaries. Gravid females and recruits of young shrimp physically appeared at approximately the same time within both systems, eliminating earlier reproduction as a cause of the size discrepancy. There were three times as many shrimp in PC than in TK (eliminating the possibility of increased population density and competition at TK as a cause) and three times as many F. heteroclitus present in TK than in PC. Since it has already been established that the Fundulus at PC are smaller than at TK and that they are poor predators, differences in Fundulus predation would appear to be an important factor in determining the number and size-frequency of the grass shrimp. 相似文献
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