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171.
FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage
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Manuela Mancini Fausto Castagnetti Simona Soverini Elisa Leo Caterina De Benedittis Gabriele Gugliotta Gianantonio Rosti Luana Bavaro Sara De Santis Cecilia Monaldi Margherita Martelli Maria Alessandra Santucci Michele Cavo Giovanni Martinelli 《Journal of cellular biochemistry》2017,118(11):3968-3975
172.
Caterina Minelli Akemi Kikuta Nataliya Tsud Michael D Ball Akiko Yamamoto 《Journal of nanobiotechnology》2008,6(1):3
Background
Polymers are attractive materials for both biomedical engineering and cardiovascular applications. Although nano-topography has been found to influence cell behaviour, no established method exists to understand and evaluate the effects of nano-topography on polymer-blood interaction. 相似文献173.
174.
Murineddu G Murruzzu C Curzu MM Chelucci G Gotti C Gaimarri A Legnani L Toma L Pinna GA 《Bioorganic & medicinal chemistry letters》2008,18(23):6147-6150
Alpha series of novel 3,6-diazabicyclo[3.1.1]heptane derivatives 4a-f was synthesized and their affinity and selectivity towards alpha4beta2 and alpha7 nAChR subtypes were evaluated. The results of the current study revealed a number of compounds (4a, 4b and 4c) having a very high affinity for alpha4beta2 (K(i) at alpha4beta2 ranging from 0.023 to 0.056 nM) versus alpha7 nAChR subtypes; among these compounds, the 3-(6-bromopyridin-3-yl)-3,6-diazabicyclo[3.1.1]heptane 4c was found to be the most alpha7alpha4beta2 selective term in receptor binding assays (alpha7alpha4beta2=1295). Moreover, compound 4d also had high affinity for the alpha4beta2 nAChR subtype (K(i)=1.2 nM) with considerably high selectivity (alpha7/alpha4beta2=23300). 相似文献
175.
Caterina MC Perillo IA Boiani L Pezaroglo H Cerecetto H González M Salerno A 《Bioorganic & medicinal chemistry》2008,16(5):2226-2234
Imidazolidine derivatives were studied as anti-Trypanosoma cruzi agents. Imidazolines can be considered as ethylenediamine/carbonyl precursors and therefore interfere with the biosynthesis of polyamines into the parasite. Some of the derivatives were found to have high and selective activity against the proliferative stages of the parasite, with IC(50) values against the epimastigote form in the low micromolar range as the reference drug Nifurtimox. The imidazolidines demonstrated to be stable after five days of incubation in buffer glucose, pH 7, indicating that diamines were not obtained in these conditions. But it was found that two of the studied diamine precursors were as active as the parent compounds. Probably, the imidazolidines affect the mitochondrial integrity according to the excreted end-products found in the NMR studies. The QSAR studies indicated that the bioactivities are correlated with the lipophilicities. In conclusion, we have described a new and relevant bioactivity for imidazolidines. The results support further in vivo studies of some of these imidazolidine derivatives. 相似文献
176.
Animals and plants both respond rapidly to pathogens by inducing the expression of defence-related genes. Within this context, a prominent role has been assigned to the lysozyme. In the present study we isolated and carried out detailed analysis of the lysozyme gene in the plant nematode Meloidogyne artiellia. The expression of lysozyme was up-regulated following exposure of M. artiellia juveniles to the Gram-negative bacterium Serratia marcescens. On the other hand, when isolated eggs containing embryos at various developmental stages were challenged with bacteria, no increase in lysozyme expression was detected. Evidence of lysozyme expression regulation was obtained in the case of adult male and females worms collected from soil. The lysozyme gene was expressed solely in the nematode intestine and, as it is predicted to be secreted, may protect the nematode from microbial infections originating in the intestinal lumen or in the pseudocoelom. This paper demonstrates, to our knowledge for the first time, the immune response to infection in a plant parasitic nematode. 相似文献
177.
Katherine Esposito Raffaele Marfella Pasquale Gualdiero Caterina Carusone Alessandro Pontillo Giovanni Giugliano Gianfranco Nicoletti Dario Giugliano 《Obesity (Silver Spring, Md.)》2003,11(5):653-659
Objective : We describe associations among the heart‐rate‐corrected QT (QTc) interval, QTc dispersion (QTc‐d), circadian BP variation, and autonomic function in obese normotensive women and the effect of sustained weight loss. Research Methods and Procedures : In 71 obese (BMI = 37.14 ± 2.6 kg/m2) women, 25 to 44 years of age, circadian BP variations (24‐hour ambulatory BP monitoring), autonomic function (power spectral analysis of RR interval oscillations), and cardiac repolarization times (QTc‐d and QTc interval) were recorded at baseline and after 1 year of a multidisciplinary program of weight reduction. Results : Compared with nonobese age‐matched women (n = 28, BMI = 23 ± 2.0 kg/m2), obese women had higher values of QTc‐d (p < 0.05) and QTc (p < 0.05), an altered sympathovagal balance (ratio of low‐frequency/high‐frequency power, p < 0.01), and a blunted nocturnal drop in BP (p < 0.01). In obese women, QTc‐d and the QTc interval correlated with diastolic nighttime BP (p < 0.01) and sympathovagal balance (p < 0.01). Waist‐to‐hip ratio, free fatty acids, and plasma insulin levels correlated with QT intervals and reduced nocturnal drops in both systolic and diastolic BP and sympathovagal balance (p < 0.01). After 1 year, obese women lost at least 10% of their original weight, which was associated with decrements of QTc‐d (p < 0.02), the QTc interval (p < 0.05), nighttime BP (p < 0.01), and sympathovagal balance (p < 0.02). Discussion : Sustained weight loss is a safe method to ameliorate diastolic nighttime BP drop and sympathetic overactivity, which may reduce the cardiovascular risk in obese women. 相似文献
178.
Giovanni Triolo Antonina Accardo-Palumbo Francesco Dieli Francesco Ciccia Angelo Ferrante Ennio Giardina Di Caterina Sano Giuseppe Licata 《Arthritis research & therapy》2003,5(5):R262
Beh?et's disease is a multisystem disease in which there is evidence of immunological dysregulation. It has been proposed
that γ/δ T cells are involved in its pathogenesis. The aim of the present study was to assess the capacity of γ/δ T cells
with phenotype Vγ9/Vδ2, from a group of Italian patients with Beh?et's disease, to proliferate in the presence of various
phosphoantigens and to express tumour necrosis factor (TNF) and IL-12 receptors. Twenty-five patients and 45 healthy individuals
were studied. Vγ9/Vδ2 T cells were analyzed by fluorescence activated cell sorting, utilizing specific monoclonal antibodies.
For the expansion of Vγ9/Vδ2 T cells, lymphocytes were cultured in the presence of various phosphoantigens. The expression
of TNF receptor II and IL-12 receptor β1 was evaluated with the simultaneous use of anti-TNF receptor II phycoerythrin-labelled (PE) or anti-IL-12 receptor β1 PE and anti-Vδ2 T-cell receptor fluorescein isothiocyanate. There was a certain hierarchy in the response of Vγ9/Vδ2 T cells
toward the different phosphoantigens, with the highest expansion factor obtained with dimethylallyl pyrophosphate and the
lowest with xylose 1P. The expansion factor was fivefold greater in patients with active disease than in those with inactive
disease or in control individuals. TNF receptor II and IL-12 receptor β1 expressions were increased in both patients and control individuals. The proportion of Vγ9/Vδ2 T cells bearing these receptors
was raised in active disease when Vγ9/Vδ2 T cells were cultured in the presence of dimethylallyl pyrophosphate. These results
indicate that Vγ9/Vδ2 T cell activation is correlated with disease progression and probably involved in the pathogenesis. 相似文献
179.
Lucia Rigamonti Mario Grosso Maria Caterina Sunseri 《The International Journal of Life Cycle Assessment》2009,14(5):411-419
Background, aim, and scope Life cycle assessment (LCA) applied to alternative waste management strategies is becoming a commonly utilised tool for decision
makers. This LCA study analyses together material and energy recovery within integrated municipal solid waste (MSW) management
systems, i.e. the recovery of materials separated with the source-separated collection of MSW and the energy recovery from
the residual waste. The final aim is to assess the energetic and environmental performance of the entire MSW management system
and, in particular, to evaluate the influence of different assumptions about recycling on the LCA results.
Materials and methods The analysis uses the method of LCA and, thus, takes into account that any recycling activity influences the environment not
only by consuming resources and releasing emissions and waste streams but also by replacing conventional products from primary
production. Different assumptions about the selection efficiencies of the collected materials and about the quantity of virgin
material substituted by the reprocessed material were made. Moreover, the analysis considers that the energy recovered from
the residual waste displaces the same quantity of energy produced in conventional power plants and boilers fuelled with fossil
fuels.
Results The analysis shows, in the expanded model of the material and energy recovering chain, that the environmental gains are higher
than the environmental impacts. However, when we reduce the selection efficiencies by 15%, the impact indicators worsen by
a percentage included between 10% and 26%. This phenomenon is even more evident when we consider a substitution ratio of 1:<1
for paper and plastic: The worsening is around 15–20% for all the impact indicators except for the global warming for which
the worsening is up to 45%.
Discussion Hypotheses about the selection efficiencies of the source-separated collected materials and about the substitution ratio have
a great influence on the LCA results. Consequently, policy makers have to be aware of the fact that the impacts of an integrated
MSW management system are highly dependent on the assumptions made in the modelling of the material recovery, as well as in
the modelling of the energy recovery.
Conclusions LCA allows to evaluate the impacts of integrated systems and how these impacts change when the assumptions made during the
modelling of the different single parts of the system are modified. Due to the significant impacts that hypotheses about material
recovery have in the results, they should be expressed in a very transparent way in the report of LCA studies, together with
the assumptions made about energy recovery.
Recommendations and perspectives The results suggest that the hypotheses about the value of the substitution ratio are very important, and the case of wood
should therefore be better analysed and a substitution ratio of 1:<1 should be used, as for paper and plastic. It seems that
the assumptions made about which material is replaced by the recycled one are very important too, and in this sense, more
research is needed about what the recycled plastic may effectively substitute, in particular the polyolefin mix. 相似文献
180.
Elena Perrino Caterina Uliva Cecilia Lanzi Piero Del Soldato Emanuela Masini Anna Sparatore 《Bioorganic & medicinal chemistry letters》2009,19(6):1639-1642
A hydrogen sulphide-releasing derivative of latanoprost acid (ACS 67) was synthesized and tested in vivo to evaluate its activity on reduction of intraocular pressure and tolerability. Glutathione (GSH) and cGMP content were also measured in the aqueous humour. The increased reduction of intraocular pressure, with a marked increase of GSH and cGMP and the related potential neuroprotective properties, make this compound interesting for the treatment of glaucoma. This is the first time that an application of a hydrogen sulphide-releasing molecule is reported for the treatment of ocular diseases. 相似文献