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121.
Mariana Milano Milton Ozório Moraes Rodrigo Rodenbusch Caroline Xavier Carvalho Melaine Delcroix Gabriel Mousquer Lucas Laux da Costa Gisela Unis Elis Regina Dalla Costa Maria Lucia Rosa Rossetti 《PloS one》2016,11(2)
In Mycobacterium tuberculosis (MTB) infection, the complex interaction of host immune system and the mycobacteria is associated with levels of cytokines production that play a major role in determining the outcome of the disease. Several single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with tuberculosis (TB) outcome. The aim of this study was to evaluate the association between previously reported SNPs IL2–330 T>G (rs2069762); IL4–590 C>T (rs2243250); IL6–174 G>C (rs1800795); IL10–592 A>C (rs1800872); IL10–1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility. We conducted a case-control study in individuals from Southern Brazil who were recruited between February 2012 and October 2013 in a high incidence TB city. We performed a multiplex genotyping assay in 191 patients with PTB and 175 healthy subjects. Our results suggest a decreased risk for PTB development associated with the IL17A -197A allele (OR = 0.29; p = 0.04), AA genotype (OR = 0.12; p = 0.04) and A carrier (AG/AA) (OR = 0.29; p = 0.004) and IL6 -174C carrier (CC/CG) (OR = 0.46; p = 0.04). We could not properly analyze IL17A -692 C>T (rs8193036) and IFNG +874T>A due to genotypic inconsistencies and found no evidence of association for the IL2, IL4, IL10 and TNF polymorphisms and PTB. In conclusion, our results show a protective effect of IL17 and IL6 polymorphisms on PTB outcome in Southern Brazilian population. 相似文献
122.
Concepta McManus Júlio Otávio Jardim Barcellos Bruna Krummenauer Formenton Potira Meirelles Hermuche Osmar Abílio de Carvalho Jr RenatoFontes Guimar?es Miguelangelo Gianezini Eduardo Antunes Dias Vinícius do Nascimento Lampert Daniele Zago José Braccini Neto 《PloS one》2016,11(1)
Movement of livestock production within a country or region has implications for genetics, adaptation, well-being, nutrition, and production logistics, particularly in continental-sized countries, such as Brazil. Cattle production in Brazil from 1977 to 2011 was spatialized, and the annual midpoint of production was calculated. Changes in the relative production and acceleration of production were calculated and spatialized using ARCGIS®. Cluster and canonical discriminant analyses were performed to further highlight differences between regions in terms of cattle production. The mean production point has moved from the Center of Minas Gerais State (in the southeast region) to the North of Goiás State (in the Midwest region). This reflects changes in environmental factors, such as pasture type, temperature and humidity. Acceleration in production in the northern region of Brazil has remained strong over the years. More recently, “traditional” cattle-rearing regions, such as the south and southeast, showed a reduction in growth rates as well as a reduction in herd size or internal migration over the period studied. These maps showed that this movement tends to be gradual, with few regions showing high acceleration or deceleration rates. 相似文献
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Discovery of A-type procyanidin dimers in yellow raspberries by untargeted metabolomics and correlation based data analysis 总被引:1,自引:0,他引:1
Elisabete Carvalho Pietro Franceschi Antje Feller Lorena Herrera Luisa Palmieri Panagiotis Arapitsas Samantha Riccadonna Stefan Martens 《Metabolomics : Official journal of the Metabolomic Society》2016,12(9):144
Introduction
Raspberries are becoming increasingly popular due to their reported health beneficial properties. Despite the presence of only trace amounts of anthocyanins, yellow varieties seems to show similar or better effects in comparison to conventional raspberries.Objectives
The aim of this work is to characterize the metabolic differences between red and yellow berries, focussing on the compounds showing a higher concentration in yellow varieties.Methods
The metabolomic profile of 13 red and 12 yellow raspberries (of different varieties, locations and collection dates) was determined by UPLC–TOF-MS. A novel approach based on Pearson correlation on the extracted ion chromatograms was implemented to extract the pseudospectra of the most relevant biomarkers from high energy LC–MS runs. The raw data will be made publicly available on MetaboLights (MTBLS333).Results
Among the metabolites showing higher concentration in yellow raspberries it was possible to identify a series of compounds showing a pseudospectrum similar to that of A-type procyanidin polymers. The annotation of this group of compounds was confirmed by specific MS/MS experiments and performing standard injections.Conclusions
In berries lacking anthocyanins the polyphenol metabolism might be shifted to the formation of a novel class of A-type procyanidin polymers.127.
128.
Ana Paula Kallaur Josiane Lopes Sayonara Rangel Oliveira Andrea Name Colado Simão Edna Maria Vissoci Reiche Elaine Regina Delicato de Almeida Helena Kaminami Morimoto Wildea Lice Carvalho Jennings de Pereira Daniele Frizon Alfieri Sueli Donizete Borelli Domacio Ramon Kaimen-Maciel Michael Maes 《Molecular neurobiology》2016,53(8):5191-5202
129.
Peter Zeilhofer Débora Fernandes Calheiros Márcia Divina de Oliveira Eliana Freire Gaspar de Carvalho Dores Gilson Alberto Rosa Lima Ibraim Fantin-Cruz 《Wetlands Ecology and Management》2016,24(6):697-716
Water quality time series available for major tropical floodplains commonly have low temporal resolutions and irregular sampling frequencies. Here we examine such data using singular spectrum analysis, a non-parametric time series analysis technique, to assess the typical cyclical variations and long-term trends in upland Cerrado and lowland floodplain reaches of three rivers that are tributaries to the Pantanal in Brazil to evaluate ecological state and impact level, and develop recommendations for improved monitoring of Cerrado–Pantanal river systems. Both upland and lowland reaches have their average water quality cycles linked to a monocyclical hydrological regime. Amplitudes of nutrient concentrations (N, P) and Turbidity are higher in the uplands, whereas cyclical oxygen variations are up to two times higher in the floodplain reaches. SSA showed that trend extraction is possible for parameters with lower intra-annual variations and were found to be partially opposing (oxygen) in upland (negative trend) and floodplain (positive trend) stations. Land use intensification in the uplands is reflected by N concentrations in upland reaches. In the floodplain, the Paraguay river was found under a slight TN enrichment regime of about 0.02 mg L?1 per year between 1995 and 2009. Assuming a fixed budget for institutional water quality monitoring, we recommend a reduction of the 150 registered sampling gauges by environmental agencies in the Brazilian Pantanal and its contribution area, 95 % of them with less than four samples per year, in favor of using the same resources for increased sampling frequency at a smaller number of sites. 相似文献
130.
Genetic and paleomodelling evidence of the population expansion of the cattle egret Bubulcus ibis in Africa during the climatic oscillations of the Late Pleistocene
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Carlos Congrains Antônio F. Carvalho Elder A. Miranda Graeme S. Cumming Dominic A. W. Henry Shiiwua A. Manu Jacinta Abalaka Cristiano D. Rocha Moussa S. Diop Joãozinho Sá Hamilton Monteiro Lars H. Holbech Francis Gbogbo Silvia N. Del Lama 《Journal of avian biology》2016,47(6):846-857
Increasing aridity during glacial periods produced the retraction of forests and the expansion of arid and semi‐arid environments in Africa, with consequences for birds. Cattle egret Bubulcus ibis is a dispersive species that prefers semi‐arid environments and requires proximity to bodies of water. We expected that climatic oscillations led to the expansion of the range of the cattle egret during arid periods, such as the Last Maximum Glacial (LGM) and contraction of distribution during the Last Interglacial (LIG) period, resulting in contact of populations previously isolated. We investigated this hypothesis by evaluating the genetic structure and population history of 15 cattle egret breeding colonies located in west and South Africa using the mitochondrial DNA (mtDNA) control region, mtDNA ATPase 8 and 6, and an intron of nuclear gene transforming growth factor‐beta 2. Occurrence data and bioclimatic information were used to generate ecological niche models of three periods (present, LGM and LIG). We used the genetic and paleomodelling data to assess the responses of the cattle egret from Africa to the climatic oscillations during the late Pleistocene. Genetic data revealed low levels of genetic differentiation, signs of isolation‐by‐distance, as well as recent increases in effective population size that started during the LGM. The observed low genetic structure may be explained by recent colonization events due to the demographic expansion following the last glacial period and by dispersal capacity of this species. The paleomodels corroborated the expansion during the LGM, and a more restricted potential distribution during the LIG. Our findinds supports the hypothesis that the species range of the cattle egret expanded during arid periods and contracted during wet periods. 相似文献