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121.
Cristina Ribeiro Roberto C Togawa Izabella AP Neshich Ivan Mazoni Adauto L Mancini Raquel C de Melo Minardi Carlos H da Silveira José G Jardine Marcelo M Santoro Goran Neshich 《BMC structural biology》2010,10(1):36
Background
Enzymes belonging to the same super family of proteins in general operate on variety of substrates and are inhibited by wide selection of inhibitors. In this work our main objective was to expand the scope of studies that consider only the catalytic and binding pocket amino acids while analyzing enzyme specificity and instead, include a wider category which we have named the Interface Forming Residues (IFR). We were motivated to identify those amino acids with decreased accessibility to solvent after docking of different types of inhibitors to sub classes of serine proteases and then create a table (matrix) of all amino acid positions at the interface as well as their respective occupancies. Our goal is to establish a platform for analysis of the relationship between IFR characteristics and binding properties/specificity for bi-molecular complexes. 相似文献122.
Jiri Soukup Helena Hornychova Monika Manethova Kvetoslava Michalova Ludmila Michnova Lenka Popovska Veronika Skarkova Tomas Cesak David Netuka Ales Ryska Jan Cap Václav Hána Václav Hána Jr Michal Kršek Eva Dvořáková Michal Krčma Ivica Lazurova Věra Olšovská Karel Starý Peter Vaňuga Filip Gabalec 《Journal of cellular and molecular medicine》2021,25(5):2484-2492
In somatotroph pituitary tumours, somatostatin analogue (SSA) therapy outcomes vary throughout the studies. We performed an analysis of cohort of patients with acromegaly from the Czech registry to identify new prognostic and predictive factors. Clinical data of patients were collected, and complex immunohistochemical assessment of tumour samples was performed (SSTR1-5, dopamine D2 receptor, E-cadherin, AIP). The study included 110 patients. In 31, SSA treatment outcome was evaluated. Sparsely granulated tumours (SGST) differed from the other subtypes in expression of SSTR2A, SSTR3, SSTR5 and E-cadherin and occurred more often in young. No other clinical differences were observed. Trouillas grading system showed association with age, tumour size and SSTR2A expression. Factors significantly associated with SSA treatment outcome included age, IGF1 levels, tumour size and expression of E-cadherin and SSTR2A. In the group of SGST, poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A and higher Ki67. We observed no relationship with expression of other proteins including AIP. No predictive value of E-cadherin was observed when tumour subtype was considered . Multiple additional factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly. 相似文献
123.