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941.
Simone Martinelli Oliver H.F. Krumbach Francesca Pantaleoni Simona Coppola Ehsan Amin Luca Pannone Kazem Nouri Luciapia Farina Radovan Dvorsky Francesca Lepri Marcel Buchholzer Raphael Konopatzki Laurence Walsh Katelyn Payne Mary Ella Pierpont Samantha Schrier Vergano Katherine G. Langley Douglas Larsen Ghayda M. Mirzaa 《American journal of human genetics》2018,102(2):309-320
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943.
Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica
Stefanie Mühlhausen Hans Dieter Schmitt Kuan-Ting Pan Uwe Plessmann Henning Urlaub Laurence D. Hurst Martin Kollmar 《Current biology : CB》2018,28(13):2046-2057.e5
944.
Krista Revert Laurence Audran Jocelyne Pengam Pascal Lesne Dominique Pougheon Bertrand 《Orphanet journal of rare diseases》2018,13(1):8
Background
The Cystic Fibrosis (CF) center in Roscoff (Brittany) has been involved in therapeutic education programs (TEP) since 2006 and took part in the pilot phase of the French quality improvement program (QIP) since 2011. The aim was to improve the nutritional status of children with cystic fibrosis aged 2-12 years old in order to optimize their health status as they enter adolescence.Methods
A multidisciplinary quality team was created in order to select and address a specific health problem among our pediatric population. Following analysis of yearly indicators for our CF center, our team chose to improve quality of care concerning nutritional status of children aged 2-12 years old. Factors influencing efficacy were studied, tools were developed to implement a new nutritional program, results were analyzed on a real-time basis.Results
Over the 3 year period, all patients from 2 years of age, were monitored with the new follow-up program (2012: N =?34; 2014: N =?44). Each patient was followed up at every clinic visit, their BMI z-score was calculated to decide their nutritional risk and personalize their follow-up program consequently. Between 1/1/2012 and 31/12/2014, the mean BMI z-score of the open cohort improved from ?0.49 to ?0.22.Conclusions
Since 2014, focus on nutrition using the newly-adapted program has become routine practice at each follow-up visit. Patients and parents expressed a high level of satisfaction (75% very satisfied). The follow-up program aimed at improving nutritional status for children aged 2-12 years old was successfully implemented and integrated into routine practice; it was therefore extended to all children with CF (1 month - 18 years) in our center. The relationship among professional and patients and parents was strengthened.945.
Anne Nègre-Salvayre Laurence Mabile Jean Delchambre Robert Salvayre 《Biological trace element research》1995,47(1-3):81-91
Low-density lipoproteins (LDL) mildly oxidized by copper ions or UV radiations exhibit a cytotoxic effect to cultured endothelial
cells. Rutin, a polyphenolic flavonoid, ascorbic acid, and α-tocopherol were able to inhibit the peroxidation of LDL and their
subsequent cytotoxicity. The mixture of the three compounds (rutin/ascorbic acid/α-tocopherol, 4/4/1) exhibited a supra-additive
antioxidant effect. The inhibition of the cytotoxic effect was well correlated with that of TBARS formation. Another important
conclusion is that these antioxidants were able to prevent directly at the cellular level the cytotoxic effect of oxidized
LDL, since cells preincubated with them were protected against the cytotoxic effect of previously oxidized LDL. The protective
effect of antioxidants was limited because of their own toxicity. The antioxidant mixture permitted a maximal cytoprotective
effect with relatively lower concentrations to be obtained and the cytotoxicity of high concentrations to be avoided. In conclusion,
rutin, ascorbic acid, and α-tocopherol constitute two lines of defense in protecting cells against injury owing to oxidation
of LDL (1) at the LDL level, by inhibiting the LDL oxidation and the subsequent cytotoxicity, and (2) at the cellular level,
by protecting the cells directly, i.e., by increasing their resistance against the cytotoxic effect of oxidized LDL. 相似文献
946.
An illustrated identification system is presented to 99 species and 49 genera in three families recorded from the Hawaiian Islands in the Thysanoptera suborder Terebrantia. Only seven (possibly eight) of these species are considered endemic, the remainder being adventive to these islands. The only previous study of Hawaiian Thysanoptera, by Zimmerman in 1948, included 47 Terebrantia species in 21 genera. 相似文献
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948.
949.
Laurence Brown 《Ethnic and racial studies》2016,39(10):1812-1830
The release of data from the 2011 census fuelled a media storm over Britain's ethnic and immigrant composition, while at the same time a much less visible series of public debates developed over the scope, organization and purpose of government information-gathering centred on how the existing census could be replaced with ‘Big data’. It is therefore particularly timely to explore the political choices, ontological shifts and statistical challenges shaping the array of enumeration projects that have developed in contemporary Britain to identify, classify, and count immigrants and their descendants. This article analyses the relationships between holistic (horizontal) and single-purpose (vertical) approaches to racial statistics, and how these were affected by the standardizations of classification in 1962 and 1991. A range of state archives and contemporary accounts are used to examine the material practices and organizational tensions that fuelled the divergence, transfer and interaction of these attempts at racial legibility. 相似文献
950.
Yolanda K. Mueller Mathieu Bastard Patrick Nkemenang Eric Comte Geneviève Ehounou Sara Eyangoh Barbara Rusch Earnest Njih Tabah Laurence Toutous Trellu Jean-Francois Etard 《PLoS neglected tropical diseases》2016,10(4)