排序方式: 共有1112条查询结果,搜索用时 31 毫秒
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992.
Camila M.B. Leite Silva Airton G. Bispo‐Jr Felipe S.M. Canisares Shirley A. Castilho Sergio A.M. Lima Ana M. Pires 《Luminescence》2019,34(8):877-886
Eu3+–β‐diketonate complexes are used, for example, in solid‐state lighting (SSL) or light‐converting molecular devices. However, their low emission quantum efficiency due to water molecules coordinated to Eu3+ and low photostability are still problems to be addressed. To overcome such challenges, we synthesized Eu3+ tetrakis complexes based on [Q][Eu(tfaa)4] and [Q][Eu(dbm)4] (Q1 = C26H56N+, Q2 = C19H42N+, and Q3 = C17H38N+), replacing the water molecules in the tris stoichiometry. The tetrakis β‐diketonates showed desirable thermal stability for SSL and, under excitation at 390 nm, they displayed the characteristic Eu3+ emission in the red spectral region. The quantum efficiencies of the dbm complexes achieved values as high as 51%, while the tfaa complexes exhibited lower quantum efficiencies (28–33%), but which were superior to those reported for the tris complexes. The structures were evaluated using the Sparkle/PM7 model and comparing the theoretical and the experimental Judd–Ofelt parameters. [Q1][Eu(dbm)4] was used to coat a near‐UV light‐emitting diode (LED), producing a red‐emitting LED prototype that featured the characteristic emission spectrum of [Q1][Eu(dbm)4]. The emission intensity of this prototype decreased only 7% after 30 h, confirming its high photostability, which is a notable result considering Eu3+ complexes, making it a potential candidate for SSL. 相似文献
993.
Johanna Chiche Julie Reverso-Meinietti Annabelle Mouchotte Camila Rubio-Patiño Rana Mhaidly Elodie Villa Jozef P. Bossowski Emma Proics Manuel Grima-Reyes Agnès Paquet Konstantina Fragaki Sandrine Marchetti Josette Briere Damien Ambrosetti Jean-François Michiels Thierry Jo Molina Christiane Copie-Bergman Jacqueline Lehmann-Che Jean-Ehrland Ricci 《Cell metabolism》2019,29(6):1243-1257.e10
994.
Arias MA Pantoja AE Jaramillo G López YP Mejía N Mejía C Paris SC Shattock RJ Griffin GE García LF 《FEMS immunology and medical microbiology》2007,49(2):272-279
The majority of knowledge about the role of cytokines and chemokines in controlling Mycobacterium tuberculosis infection mainly derives from animal models. In humans, this knowledge is still mainly limited to the blood compartment or accessible lymphoid organs, such as tonsils. Here, we studied cytokine and chemokine production and their modulation by M. tuberculosis antigens in mononuclear cells from human blood, spleen and hilar lung lymph nodes. Results show that the kinetics and magnitude of cytokine and chemokine production varied according to the tissue of cell origin. Mycobacterium tuberculosis antigens enhanced cytokine and chemokine production in blood, but the enhancement was restricted in spleen and hilar lung lymph node cells. We show, for the first time in humans, differences in cytokine and chemokine microenvironments according to lymphoid tissues, and suggest that these differences may affect the way cells respond to M. tuberculosis infection. 相似文献
995.
Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination 总被引:1,自引:0,他引:1
Esguerra CV Nelles L Vermeire L Ibrahimi A Crawford AD Derua R Janssens E Waelkens E Carmeliet P Collen D Huylebroeck D 《Development (Cambridge, England)》2007,134(24):4381-4393
During vertebrate development, signaling by the TGFbeta ligand Nodal is critical for mesoderm formation, correct positioning of the anterior-posterior axis, normal anterior and midline patterning, and left-right asymmetric development of the heart and viscera. Stimulation of Alk4/EGF-CFC receptor complexes by Nodal activates Smad2/3, leading to left-sided expression of target genes that promote asymmetric placement of certain internal organs. We identified Ttrap as a novel Alk4- and Smad3-interacting protein that controls gastrulation movements and left-right axis determination in zebrafish. Morpholino-mediated Ttrap knockdown increases Smad3 activity, leading to ectopic expression of snail1a and apparent repression of e-cadherin, thereby perturbing cell movements during convergent extension, epiboly and node formation. Thus, although the role of Smad proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays an essential role in the fine-tuning of this signal transduction cascade. 相似文献
996.
Forlenza OV Mendes CT Marie SK Gattaz WF 《Prostaglandins, leukotrienes, and essential fatty acids》2007,76(1):47-55
Phospholipase A2 (PLA(2)) has been implicated in neurodevelopmental processes and in the early development of the nervous system. We investigated the effects of the inhibition of calcium-dependent and calcium-independent subtypes of cytosolic PLA2 (cPLA2 and iPLA2) on the development and viability of primary cultures of cortical and hippocampal neurons. PLA2 in these cultures was continuously inhibited with methylarachidonyl-fluorophosphonate (MAFP), an irreversible inhibitor of cPLA2 and iPLA2, or with bromoenol lactone (BEL), an irreversible selective iPLA2 inhibitor. The effect of PLA2 inhibitors on the development of neuronal cultures was ascertained by total cell count and morphological characterisation. Neuronal viability was quantified with MTT assays. Inhibition of PLA2 resulted in reduction of neuritogenesis and neuronal viability, disrupting neuronal homeostasis and leading to neuronal death. We conclude that the functional integrity of both calcium-dependent and calcium-independent cytosolic PLA2 is necessary for the in vitro development of cortical and hippocampal neurons. 相似文献
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Silva Daniela Fernanda Dezotti de Oliveira Fujii Lucas Chiarotto Gabriela Bortolança de Oliveira Camila Andrea de Andrade Thiago Antônio Moretti de Oliveira Alexandre Leite Rodrigues Esquisatto Marcelo Augusto Marretto Mendonça Fernanda Aparecida Sampaio dos Santos Gláucia Maria Tech de Aro Andrea Aparecida 《Molecular biology reports》2021,48(2):1233-1241
Molecular Biology Reports - The literature has shown the beneficial effects of microcurrent (MC) therapy on tissue repair. We investigated if the application of MC at... 相似文献
998.
Camila Lopez-Crisosto Raul Arias-Carrasco Pablo Sepulveda Luis Garrido-Olivares Vinicius Maracaja-Coutinho Hugo E. Verdejo Pablo F. Castro Sergio Lavandero 《生物化学与生物物理学报:疾病的分子基础》2021,1867(10):166200
Pulmonary hypertension is a rare disease with high morbidity and mortality which mainly affects women of reproductive age. Despite recent advances in understanding the pathogenesis of pulmonary hypertension, the high heterogeneity in the presentation of the disease among different patients makes it difficult to make an accurate diagnosis and to apply this knowledge to effective treatments. Therefore, new studies are required to focus on translational and personalized medicine to overcome the lack of specificity and efficacy of current management. Here, we review the majority of public databases storing ‘omics’ data of pulmonary hypertension studies, from animal models to human patients. Moreover, we review some of the new molecular mechanisms involved in the pathogenesis of pulmonary hypertension, including non-coding RNAs and the application of ‘omics’ data to understand this pathology, hoping that these new approaches will provide insights to guide the way to personalized diagnosis and treatment. 相似文献
999.
De Carvalho Flavia Giolo Brandao Camila Fernanda Cunha Muñoz Vitor Rosetto Batitucci Gabriela Tavares Maria Eduarda de Almeida Teixeira Giovana Rampazzo Pauli José Rodrigo De Moura Leandro Pereira Ropelle Eduardo Rochete Cintra Dennys Esper da Silva Adelino Sanchez Ramos Junqueira‐Franco Márcia Varella Morandi Marchini Julio Sergio De Freitas Ellen Cristini 《Amino acids》2021,53(9):1391-1403
Amino Acids - Interventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory... 相似文献
1000.
Camila A. Orellana Vernica S. Martínez Michael A. MacDonald Matthew N. Henry Marianne Gillard Peter P. Gray Lars K. Nielsen Stephen Mahler Esteban Marcellin 《Biotechnology and bioengineering》2021,118(1):481-490
Chinese hamster ovary (CHO) cells are widely used in biopharmaceutical production. Improvements to cell lines and bioprocesses are constantly being explored. One of the major limitations of CHO cell culture is that the cells undergo apoptosis, leading to rapid cell death, which impedes reaching high recombinant protein titres. While several genetic engineering strategies have been successfully employed to reduce apoptosis, there is still room to further enhance CHO cell lines performance. ‘Omics analysis is a powerful tool to better understand different phenotypes and for the identification of gene targets for engineering. Here, we present a comprehensive review of previous CHO 'omics studies that revealed changes in the expression of apoptosis‐related genes. We highlight targets for genetic engineering that have reduced, or have the potential to reduce, apoptosis or to increase cell proliferation in CHO cells, with the final aim of increasing productivity. 相似文献