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SMM?VerstappenEmail author AR?Poole M?Ionescu LE?King M?Abrahamowicz DM?Hofman JWJ?Bijlsma FPJG?Lafeber the Utrecht Rheumatoid Arthritis Cohort Study group 《Arthritis research & therapy》2005,8(1):R31
Introduction
The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patients with rheumatoid arthritis (RA). 相似文献43.
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A Sahaboglu O Paquet-Durand J Dietter K Dengler S Bernhard-Kurz P AR Ekstr?m B Hitzmann M Ueffing F Paquet-Durand 《Cell death & disease》2013,4(2):e488
For most neurodegenerative diseases the precise duration of an individual cell''s death is unknown, which is an obstacle when counteractive measures are being considered. To address this, we used the rd1 mouse model for retinal neurodegeneration, characterized by phosphodiesterase-6 (PDE6) dysfunction and photoreceptor death triggered by high cyclic guanosine-mono-phosphate (cGMP) levels. Using cellular data on cGMP accumulation, cell death, and survival, we created mathematical models to simulate the temporal development of the degeneration. We validated model predictions using organotypic retinal explant cultures derived from wild-type animals and exposed to the selective PDE6 inhibitor zaprinast. Together, photoreceptor data and modeling for the first time delineated three major cell death phases in a complex neuronal tissue: (1) initiation, taking up to 36 h, (2) execution, lasting another 40 h, and finally (3) clearance, lasting about 7 h. Surprisingly, photoreceptor neurodegeneration was noticeably slower than necrosis or apoptosis, suggesting a different mechanism of death for these neurons. 相似文献
45.
P. CRUZ A. M. IBARRA G. FIORE‐AMARAL C. E. GALINDO‐SNCHEZ G. MENDOZA‐CARRI
N 《Molecular ecology resources》2005,5(4):857-859
Microsatellite loci were isolated in Haliotis fulgens using a (CT)n enriched‐genomic library. From 33 sequenced clones, 21 microsatellites regions were identified, 15 with the expected (CT)n. Eight microsatellite loci were amplified, six of which were polymorphic with a range of three to 20 alleles, and five cross‐amplified in two other species (Haliotis rufescens and Haliotis corrugata). These microsatellites will be useful as population genetic markers in the three species. 相似文献
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In many cases of interspecific kleptoparasitism, hosts developdefensive behaviors to minimize the impact of kleptoparasites.Because vigilance and defensive behaviors are often costly,selection should favor hosts that adjust the amount of investmentneeded to minimize losses to kleptoparasitism. However, examplesof such facultative responses are rare. Here, we investigatethe response of cooperatively breeding pied babblers (Turdoidesbicolor) to the drongo (Dicrurus adsimilis), an avian kleptoparasitethat regularly follows pied babbler groups, often giving alarmcalls to alert the group to predators but also occasionallygiving false alarm calls in order to steal food items. We showthat pied babbler response to drongos varies markedly accordingto babbler group size. In small groups, where there are fewindividuals available to act as sentinels, babblers sentinelless when a drongo is present and respond strongly to drongoalarm calls. However, in large groups, where there are manyindividuals available to participate in predator vigilance,babblers sentinel more often when a drongo is present, rarelyrespond to drongo alarm calls, and aggressively displace drongos,with a consequent decline in the number of successful kleptoparasitismevents. This behavior represent a facultative response to akleptoparasite according to the costs versus benefits of toleratingtheir presence. 相似文献
48.
N. GARCÍA-MAGALLANES F. LUQUE-ORTEGA E. M. AGUILAR-MEDINA R. RAMOS-PAYÁN C. GALAVIZ-HERNÁNDEZ J. G. ROMERO-QUINTANA L. DEL POZO-YAUNER H. RANGEL-VILLALOBOS E. ARÁMBULA-MERAZ 《Journal of genetics》2014,93(2):325-330
Glucose-6-phosphate dehydrogenase deficiency (G6PD) is the most common enzyme pathology in humans; it is X-linked inherited and causes neonatal hyperbilirubinaemia, chronic nonspherocytic haemolytic anaemia and drug-induced acute haemolytic anaemia. G6PD deficiency has scarcely been studied in the northern region of Mexico, which is important because of the genetic heterogeneity described in Mexican population. Therefore, samples from the northern Mexico were biochemically screened for G6PD-deficiency, and PCR-RFLPs, and DNA sequencing used to identify mutations in positive samples. The frequency of G6PD deficiency in the population was 0.95% (n = 1993); the mutations in 86% of these samples were G6PD A?202A/376G , G6PD A?376G/968C and G6PD Santamaria376G/542T . Contrary to previous reports, we demonstrated that G6PD deficiency distribution is relatively homogenous throughout the country (P = 0.48336), and the unique exception with high frequency of G6PD deficiency does not involve a coastal population (Chihuahua: 2.4%). Analysis of eight polymorphic sites showed only 10 haplotypes. In one individual we identified a new G6PD mutation named Mexico DF193A>G (rs199474830), which probably results in a damaging functional effect, according to PolyPhen analysis. Proteomic impact of the mutation is also described. 相似文献
49.
JENNYFFER CRUZ DUNCAN R. SUTHERLAND GARY R. MARTIN LUKE K.‐P. LEUNG 《Austral ecology》2012,37(8):893-902
Body size is often associated with a dietary divergence within taxonomically related groups so that large animals are often folivorous, while smaller species shift progressively towards omnivory or carnivory. This trend may be influenced by allometric constrains which result in relatively high energetic requirements, but low gut capacities in small animals, compared to their large counterparts. The common brushtail possum (Trichosurus vulpecula, Phalangeridae) has six subspecies ranging widely in weight (1–4 kg). They are not strictly folivorous, but supplement their diet with more nutritious, non‐foliar foods. We predicted that T. vulpecula subspecies diverged in diet in association with body size, with smaller subspecies consuming higher proportions of non‐foliar foods. We assessed this with a review and a meta‐analysis of previous Australian studies. We also investigated the previously unquantified diet of T. v. hypoleucus at three sites in the northern jarrah forest of Western Australia. Results from the meta‐analysis and the review supported our prediction. However, the large variability in the data highlighted their limitations and those of the techniques commonly used to quantify the diet of T. vulpecula. Nonetheless, small subspecies of T. vulpecula appear to consume higher proportions of non‐foliar foods. These results should encourage further research into the body size/diet relationship within T. vulpecula and other possum species. Results from the dietary study of T. v. hypoleucus emphasized their omnivorous diet, which was dominated by foliage and flowers and smaller proportions of invertebrates, seeds and fruits. The common brushtail possum is seldom an exclusive arboreal folivore, but rather ranges from folivory to omnivory. 相似文献
50.
Lucas Bleicher Ricardo Aparicio Fabio M Nunes Leandro Martinez Sandra M Gomes Dias Carolina Migliorini Ana Figueira Auxiliadora Morim Maria Santos Walter H Venturelli Rosangela da Silva Paulo Marcos Donate Francisco AR Neves Luiz A Simeoni John D Baxter Paul Webb Munir S Skaf Igor Polikarpov 《BMC structural biology》2008,8(1):1-13